PROSITE entry PS50020

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PURL: https://purl.expasy.org/prosite/signature/PS50020

Direct ScanProsite submission

General information about the entry

Entry name [info]	WW_DOMAIN_2
Accession [info]	PS50020
Entry type [info]	MATRIX
Date [info]	01-NOV-1995 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50020
Associated ProRule [info]	PRU00224

Name and characterization of the entry

Description [info]

WW/rsp5/WWP domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=34;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=31;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2776000; R2=0.0197000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1518.2681885; R2=1.0788643; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=418; H_SCORE=1969; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=316; H_SCORE=1859; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S';  M= -5, -9,-25,-10, -3,-21, -5,-13,-15, -7,-16, -9, -6, -1,  0, -5,  2,  1,-13,-26,-17, -3;
/M: SY='P';  M= -7, -5,-30, -1, -1,-24, -5,-13,-22, -9,-24,-17, -4, 27, -6,-13,  0, -5,-24,-29,-22, -5;
/M: SY='L';  M= -8,-23,-19,-24,-18,  2,-27,-18, 15,-22, 29, 12,-22,-24,-16,-14,-21, -7, 12,-24, -5,-18;
/M: SY='P';  M= -9,-10,-34, -5,  7,-27,-18,-12,-18, -6,-23,-13,-10, 49,  1,-13, -5, -8,-26,-29,-23,  1;
/M: SY='P';  M= -1, -1,-24,  1, -2,-22, -6,-11,-21, -5,-24,-17,  2, 12, -5,-10,  8,  1,-19,-29,-17, -5;
/M: SY='G';  M= -4, -9,-31, -7,-11,-29, 34,-14,-30,-16,-27,-18, -3,  4,-12,-18, -1,-14,-27,-24,-25,-13;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='E';  M= -8,  0,-25,  3, 24,-20,-20, -7,-21, 15,-18,-10, -3, -8,  9,  5, -2, -3,-16,-25,-12, 16;
/M: SY='E';  M= -1, -8,-15, -8,  7,-19,-15,-11,-13,  1,-11, -5, -9,-15,  1,  1, -3, -5, -6,-26,-15,  3;
/M: SY='R';  M= -2,-16,-23,-18,-12, -7,-20, -4, -7, -1, -7, -3,-12,-21, -7,  6, -9, -8, -2,-10,  2,-11;
/M: SY='Y';  M=-11,-14,-24,-18, -8,  4,-25,-10, -5, -4, -4,  1,-12,-19, -4, -5,-10, -2, -5, -7,  5, -6;
/M: SY='D';  M= -5, 17,-20, 19,  3,-23,-11,  1,-22, -6,-20,-14, 10,-12, -2, -9, 10, 10,-15,-34,-13,  0;
/M: SY='B';  M= -2,  6,-25,  6,  3,-26, -6, -8,-23, -1,-23,-16,  4,  3, -3, -8,  3,  0,-19,-29,-18, -1;
/M: SY='N';  M= -7, 10,-22, 10,  8,-21,-13, -6,-22,  6,-22,-15, 11,-13,  1,  2,  7,  2,-16,-31,-15,  5;
/I:         MD=-27;
/M: SY='G';  M= -3, -5,-26, -7,-11,-23, 30,-13,-28, -3,-23,-12,  2,-17,-10, -7, -2,-11,-22,-18,-17,-11; D=-5;
/I:         I=-10; MI=-5; MD=-27; IM=-5; DM=-27;
/M: SY='R';  M=-13,-10,-25,-12, -3,-14,-17, -7,-18, 14,-14, -7, -4,-18,  3, 34, -7, -4,-11,-20, -8, -3; D=-5;
/I:         DM=-27;
/M: SY='P';  M= -7,-15,-25,-16, -9, -8,-23,-17, -5, -7,-11, -7,-13,  5,-11, -9, -5,  3, -4,-14, -5,-12;
/M: SY='Y';  M=-19,-24,-26,-27,-24, 40,-30,  5,  4,-17,  4,  1,-20,-30,-19,-14,-20,-10, -3, 20, 59,-24;
/M: SY='Y';  M=-20,-24,-26,-28,-24, 50,-30,  4,  0,-18,  4,  0,-20,-30,-22,-14,-20,-10, -6, 22, 60,-24;
/M: SY='Y';  M=-12,-26,-25,-29,-24, 10,-29, -9, 13,-21,  7,  5,-22,-26,-19,-18,-18, -8, 10,  6, 14,-23;
/M: SY='N';  M=-12, 40,-22, 29,  4,-24, -3, 12,-24,  0,-30,-21, 51,-18,  0, -2,  7, -3,-30,-40,-18,  2;
/M: SY='H';  M=-12, -5,-28, -5, -3,-18,-20, 39,-19, -8,-12, -3, -1, -5,  0, -4, -9,-10,-19,-28,  2, -5;
/M: SY='E';  M= -5,  2,-23,  0,  9,-19,-17, -8,-12,  2,-13, -9,  5,-10,  2, -3, -1, -3,-11,-29,-15,  5;
/M: SY='T';  M= -1,  3,-13, -5, -8,-12,-17,-16,-10,-10,-11,-11,  5,-12, -8,-11, 17, 34, -3,-32,-12, -8;
/M: SY='K';  M=-11,  1,-29, -1,  4,-28, -7,  1,-29, 25,-27,-10,  6,-14, 11, 22, -6,-11,-24,-22,-12,  7;
/M: SY='E';  M= -7,  5,-23,  5, 17,-23,-19, -4,-23, 10,-20,-13,  2, -8,  7,  5,  5, 10,-17,-28,-12, 12;
/M: SY='T';  M=  3,  0,-10, -7, -7,-13,-14,-17,-13,-10,-16,-13,  3,-10, -7,-10, 26, 40, -3,-33,-13, -7;
/M: SY='Q';  M= -6, -5,-11, -8,  0,-19,-19, -5,-16, -3,-14, -7, -3,-15, 14,  1,  7, 11,-14,-25, -7,  6;
/M: SY='W';  M=-19,-36,-45,-37,-28, 14,-21,-24,-17,-19,-16,-17,-35,-29,-20,-19,-34,-24,-25,124, 33,-20;
/M: SY='E';  M= -9,  4,-25,  9, 19,-22,-20, -6,-15,  0,-14,-11, -2,-10,  8, -5,  0, -2,-14,-27,-10, 13;
/M: SY='D';  M=-15,  5,-32, 12,  8,-29,-18,  4,-27, 10,-25,-15,  1, 11,  2,  8, -8,-11,-24,-29,-14,  2;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='R';  M= -9,  1,-23,  0,  1,-20,-14, -8,-21, 10,-16,-11,  2,-16,  0, 19, -1,  0,-13,-27,-13, -1;
/M: SY='M';  M=-10,-15,-24,-17, -8, -2,-13,-10, -6,-11, -1,  2,-12,-11,-11, -8,-11, -6, -6,-20, -6,-10;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	392 in 227 different sequences
Number of true positive hits	392 in 227 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	17
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	95.84 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	4
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann
Feature key [info]	DOMAIN
Feature description [info]	WW
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

227 sequences

APBB1_HUMAN (O00213), APBB1_MOUSE (Q9QXJ1), APBB1_RAT   (P46933),

APBB2_HUMAN (Q92870), APBB2_MOUSE (Q9DBR4), APBB3_HUMAN (O95704), 
APBB3_MOUSE (Q8R1C9), APBB3_RAT   (O35827), BAG3_HUMAN  (O95817), 
BAG3_MOUSE  (Q9JLV1), CAPAM_DANRE (A0A0R4IKJ1), CAPAM_HUMAN (Q9H4Z3), 
CAPAM_MOUSE (P59114), CE164_HUMAN (Q9UPV0), CE164_MOUSE (Q5DU05), 
CMTR1_BOVIN (A2VE39), CMTR1_DANRE (Q803R5), CMTR1_MOUSE (Q9DBC3), 
CMTR1_XENLA (Q6GQ76), DB10_NICSY  (P46942), DGCR8_BOVIN (A6QR44), 
DGCR8_HUMAN (Q8WYQ5), DGCR8_MOUSE (Q9EQM6), DMDA_DROME  (Q9VDW6), 
DMDB_DROME  (Q9VDW3), DMDD_DROME  (Q0KI50), DMDE_DROME  (Q7YU29), 
DMD_CAEEL   (Q9TW65), DMD_CANLF   (O97592), DMD_CHICK   (P11533), 
DMD_HUMAN   (P11532), DMD_MOUSE   (P11531), DMD_PIG (Q5GN48), 
DMD_RAT (P11530), DOD_DROME   (P54353), DRE4_SCHPO  (Q09685), 
DRP2_HUMAN  (Q13474), DRP2_MOUSE  (Q05AA6), DRP2_RAT(Q9EPA0), 
DWWA_DICDI  (Q54T86), ESS1_YEAST  (P22696), FCA_ARATH   (O04425), 
FCA_ORYSI   (B8BCZ8), FCA_ORYSJ   (Q6K271), FEH1_CAEEL  (Q9BKZ9), 
FNBP4_HUMAN (Q8N3X1), FNBP4_MOUSE (Q6ZQ03), FRPD4_HUMAN (Q14CM0), 
FRPD4_MOUSE (A2AFR3), GAS7_HUMAN  (O60861), GAS7_MOUSE  (Q60780), 
GAS7_RAT(O55148), HECW1_CAEEL (Q09291), HECW1_HUMAN (Q76N89), 
HECW1_MOUSE (Q8K4P8), HECW2_HUMAN (Q9P2P5), HECW2_MOUSE (Q6I6G8), 
IQGA1_HUMAN (P46940), IQGA2_HUMAN (Q13576), IQGA2_MOUSE (Q3UQ44), 
ITCH_HUMAN  (Q96J02), ITCH_MOUSE  (Q8C863), KIBRA_DROAN (B3LWS4), 
KIBRA_DROER (B3P3M8), KIBRA_DROME (Q9VFG8), KIBRA_DROMO (B4K6I9), 
KIBRA_DROSE (B4HEJ6), KIBRA_DROVI (B4M5X4), KIBRA_DROWI (B4NAD3), 
KIBRA_DROYA (B4PSQ2), KIBRA_HUMAN (Q8IX03), KIBRA_MOUSE (Q5SXA9), 
KIBRA_XENTR (A4IIJ3), MAGI1_HUMAN (Q96QZ7), MAGI1_MOUSE (Q6RHR9), 
MAGI1_RAT   (Q4L1J4), MAGI2_HUMAN (Q86UL8), MAGI2_MOUSE (Q9WVQ1), 
MAGI2_RAT   (O88382), MAGI3_CHICK (Q5F488), MAGI3_HUMAN (Q5TCQ9), 
MAGI3_MOUSE (Q9EQJ9), MAGI3_RAT   (Q9JK71), MAGI3_XENTR (A1A5G4), 
NCFA_DICDI  (Q867T7), NED4L_HUMAN (Q96PU5), NED4L_MOUSE (Q8CFI0), 
NED4L_PONAB (Q5RBF2), NEDD4_DROME (Q9VVI3), NEDD4_HUMAN (P46934), 
NEDD4_MOUSE (P46935), NEDD4_RAT   (Q62940), PIN1_BOVIN  (Q5BIN5), 
PIN1_HUMAN  (Q13526), PIN1_MACFA  (Q4R383), PIN1_MOUSE  (Q9QUR7), 
PIN1_RHIO9  (P0C1J8), PIN1_SCHPO  (O74448), PINL_HUMAN  (O15428), 
PKHA5_HUMAN (Q9HAU0), PKHA7_DANRE (B6RSP1), PKHA7_HUMAN (Q6IQ23), 
PKHA7_MOUSE (Q3UIL6), PQBP1_BOVIN (Q2HJC9), PQBP1_GORGO (A1YFA7), 
PQBP1_HUMAN (O60828), PQBP1_MOUSE (Q91VJ5), PQBP1_PONPY (A2T806), 
PQBP1_RAT   (Q6PCT5), PR40A_ARATH (B6EUA9), PR40A_HUMAN (O75400), 
PR40A_MOUSE (Q9R1C7), PR40B_ARATH (F4JCC1), PR40B_HUMAN (Q6NWY9), 
PR40B_MOUSE (Q80W14), PR40C_ARATH (Q9LT25), PRP40_SCHPO (O14176), 
PRP40_YEAST (P33203), PUB1_SCHPO  (Q92462), PUB2_SCHPO  (Q9UTG2), 
PUB3_SCHPO  (O14326), RH14_ARATH  (Q8H136), RH14_ORYSJ  (Q5VQL1), 
RH40_ARATH  (Q9SQV1), RH40_ORYSJ  (Q5JKF2), RH46_ARATH  (Q9LYJ9), 
RHG09_HUMAN (Q9BRR9), RHG12_HUMAN (Q8IWW6), RHG12_MACFA (Q9BE31), 
RHG12_MOUSE (Q8C0D4), RHG27_HUMAN (Q6ZUM4), RHG27_MOUSE (A2AB59), 
RHG27_RAT   (Q6TLK4), RHG39_HUMAN (Q9C0H5), RHG39_MOUSE (P59281), 
RSP5_ASPCL  (A1CQG2), RSP5_ASPFC  (B0XQ72), RSP5_ASPFN  (B8N7E5), 
RSP5_ASPFU  (Q4WTF3), RSP5_ASPNC  (A2QQ28), RSP5_ASPOR  (Q2UBP1), 
RSP5_ASPTN  (Q0CCL1), RSP5_CHATD  (G0S9J5), RSP5_EMENI  (Q5BDP1), 
RSP5_NEOFI  (A1D3C5), RSP5_YEAST  (P39940), SAC9_ARATH  (Q7XZU0), 
SAV1_HUMAN  (Q9H4B6), SAV1_MOUSE  (Q8VEB2), SAV1_RAT(A4V8B4), 
SAV_DROME   (Q9VCR6), SEC24_CRYNB (P0CR41), SEC24_CRYNJ (P0CR40), 
SEC24_MYCMD (Q4P9K4), SET2_ASPOR  (Q2UTN6), SET2_CANAL  (Q59XV0), 
SET2_CANGA  (Q6FX50), SET2_CHAGB  (Q2H988), SET2_COCIM  (Q1DU03), 
SET2_DEBHA  (Q6BM04), SET2_DROME  (Q9VYD1), SET2_EMENI  (Q5ASA5), 
SET2_GIBZE  (Q4IB50), SET2_NEUCR  (Q7RZU4), SET2_YARLI  (Q6C5G5), 
SETD2_HUMAN (Q9BYW2), SETD2_MOUSE (E9Q5F9), SMUF1_DROME (Q9V853), 
SMUF1_HUMAN (Q9HCE7), SMUF1_MOUSE (Q9CUN6), SMUF1_XENLA (Q9PUN2), 
SMUF2_DANRE (A9JRZ0), SMUF2_HUMAN (Q9HAU4), SMUF2_MOUSE (A2A5Z6), 
SMUF2_XENLA (Q2TAS2), SSP1_NEUCR  (O60045), STXB4_HUMAN (Q6ZWJ1), 
STXB4_MOUSE (Q9WV89), SUDX_DROME  (Q9Y0H4), TCRG1_HUMAN (O14776), 
TCRG1_MOUSE (Q8CGF7), TCRGL_HUMAN (Q5VWI1), TCRGL_MOUSE (Q3B807), 
TG325_CAEEL (P46941), URN1_YEAST  (Q06525), UTRN_HUMAN  (P46939), 
UTRN_RAT(G3V7L1), WAC_DANRE   (Q7ZUK7), WAC_DROME   (Q9VX88), 
WAC_HUMAN   (Q9BTA9), WAC_MOUSE   (Q924H7), WAC_XENTR   (Q5U4Q0), 
WBP4_CHICK  (Q5F457), WBP4_HUMAN  (O75554), WBP4_MOUSE  (Q61048), 
WBP4_RAT(Q5HZF2), WWC2_HUMAN  (Q6AWC2), WWC2_MOUSE  (Q6NXJ0), 
WWC2_XENTR  (Q6DJR2), WWC3_HUMAN  (Q9ULE0), WWM1_YEAST  (P43582), 
WWOX_CHICK  (Q5F389), WWOX_DANRE  (Q803A8), WWOX_DROME  (Q9VLU5), 
WWOX_HUMAN  (Q9NZC7), WWOX_MOUSE  (Q91WL8), WWOX_PONAB  (Q5R9W5), 
WWP1_CAEEL  (Q9N2Z7), WWP1_HUMAN  (Q9H0M0), WWP1_MOUSE  (Q8BZZ3), 
WWP2_HUMAN  (O00308), WWP2_MOUSE  (Q9DBH0), WWTR1_CANLF (A0A8I3PQN6), 
WWTR1_HUMAN (Q9GZV5), WWTR1_MOUSE (Q9EPK5), YAP1A_XENLA (D6C652), 
YAP1_CAEEL  (Q19404), YAP1_CANLF  (A0A8C0NGY6), YAP1_CHICK  (P46936), 
YAP1_DANRE  (Q1L8J7), YAP1_DROME  (Q45VV3), YAP1_HUMAN  (P46937), 
YAP1_MOUSE  (P46938), YAP1_ORYLA  (H2LBU8), YAP1_RAT(Q2EJA0), 
YO61_CAEEL  (P34600), ZYS3_CHLRE  (Q8GSP8)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

17 sequences

CFL1_ARATH  (Q5HZ54), CFL1_ORYSI  (B8AIM8), CFL1_ORYSJ  (Q0E0W7),

CFL2_ARATH  (Q9C7E6), CMTR1_AILME (D2HRF1), CMTR1_HUMAN (Q8N1G2), 
CMTR1_PONAB (Q5R981), CMTR1_RAT   (Q5U2Z5), IQGA1_MOUSE (Q9JKF1), 
SET2_ASPFU  (Q4WTT2), SET2_EREGS  (Q757Y8), SET2_KLULA  (Q6CXP5), 
SET2_YEAST  (P46995), YERE_SCHPO  (O14097), YHK5_SCHPO  (O94425), 
YHK6_SCHPO  (O94426), YNI8_SCHPO  (O13598)

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PDB
[Detailed view]

246 PDB

1E0L; 1E0N; 1EG3; 1EG4; 1F8A; 1I5H; 1I6C; 1I8G; 1I8H; 1JMQ; 1K5R; 1K9Q;
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