PROSITE entry PS50018

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PURL: https://purl.expasy.org/prosite/signature/PS50018

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General information about the entry

Entry name [info]	RAS_GTPASE_ACTIV_2
Accession [info]	PS50018
Entry type [info]	MATRIX
Date [info]	01-NOV-1995 CREATED; 18-JUN-2025 DATA UPDATE; 18-JUN-2025 INFO UPDATE.
PROSITE Doc. [info]	PDOC00438
Associated ProRule [info]	PRU00167

Name and characterization of the entry

Description [info]

Ras GTPase-activating proteins (rasGAP) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=225;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=220;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8049119; R2=0.0088608; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1038; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=530; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-30; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='N';  M= -28, -74,  -3,   2,   9,  40,  43, -67, -18, -16, -61,  44,   3, -57, -63,  17, -57, -19, -70,  34;
/M: SY='L';  M= -15, -72, -71, -62, -49, -76, -60, -47,  45,  58, -43, -67, -76, -56,  30, -25, -60, -11, -66,  40;
/M: SY='L';  M=  26,  -5, -74, -20,   4, -74, -69,  36, -66,  52, -41, -70, -75,  -9,  -6, -27,  -1,  -6, -73, -56;
/M: SY='L';  M=   0, -72,  25, -59, -55, -16,  25, -49,  16,  50, -46, -60, -73,   0, -21, -19,  -3,  -1, -73,  14;
/M: SY='Q';  M= -11, -78,  17, -25, -75, -30, -57, -10,  10, -33, -62, -54,  48,  68,  35,  27, -56, -67, -75, -18;
/M: SY='F';  M= -30, -69, -82, -76,  72, -80, -70, -19, -75,  56, -39, -76, -81, -75, -74, -12, -20,  32, -62, -41;
/M: SY='L';  M= -40, -70, -84, -78,  44, -85, -73,  42, -77,  53, -37, -79, -81, -75, -76, -72, -59,  48, -67,  -1;
/M: SY='C';  M= -29,  76,   8, -54, -72, -66, -63, -73,  31, -72, -66, -52, -69,   4,  41,  37,  47, -67,  52, -64;
/M: SY='Y';  M=   2, -73,  40,  26, -57, -66, -52, -64, -54,  -1,   3,  34, -69,  22, -19,  -8,  30, -63, -68,  58;
/M: SY='L';  M=  14, -68, -78, -72, -49, -75,  21,   4, -72,  62,  58, -72, -77, -65, -71,  -4, -57,  23, -76, -55;
/M: SY='I';  M=   9, -70, -73, -72,  23, -24, -68,  55, -26,  37,  -7,  11, -74, -67, -70, -10,  -1, -16, -69,  -8;
/M: SY='Q';  M= -36, -76,  19,  37, -74, -27, -55, -69,  35, -68,  32, -51, -64,  63,  15,  10,  20, -33, -76, -10;
/M: SY='N';  M=  -6, -73, -55,  30,   4, -69,  15, -11,  26,  25, -53,  39, -69,  30,   8,  -8, -18, -59, -75, -58;
/M: SY='E';  M= -14, -79,  11,  97, -84, -71, -53, -82, -43, -76, -70, -12, -58,  50, -51, -23, -59, -75, -80, -71;
/M: SY='I';  M= -20, -72, -82, -76,   9, -83, -71,  58, -74,  46,  33, -76, -78, -11, -74, -70, -59,  36, -69,  12;
/M: SY='K';  M=  20, -71,  24,  27,  -1, -40, -58, -65,  48,  -4, -61,  21, -67, -50, -34,  26, -54, -25, -74,  -6;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='R';  M= -28, -74,  -8,  20, -68, -35,  23, -64,  36,  12,   9, -10, -69, -47,  59,  19, -25, -30, -78, -62;
/M: SY='C';  M=  17,  46, -65, -19, -26,  -6, -70,   1, -25, -12, -55, -12, -70, -63, -68,  28,  45,  37, -81, -65;
/M: SY='D';  M=   1, -74,  56,  11, -79,   5,   4, -76,   9, -75,   9,  34,  12,  30, -56,  32, -27, -72, -84, -68;
/M: SY='Q';  M= -57, -75,  53,  36, -77, -21, -55, -69, -49, -25, -65,  29, -66,  57,   0,  37, -15, -11, -84, -67;
/M: SY='P';  M=  13, -74, -31, -25,   5, -31, -27,   8, -60, -55,  68, -28,  69, -21,   1,   2, -28,   9, -75, -61;
/M: SY='Q';  M= -61, -76,   7,  35, -76,  -7,  -7, -14, -43, -38, -62,  60, -68,  60,  45, -51,  13, -69, -81, -66;
/M: SY='T';  M= -10, -70,  55, -17, -73, -30,  13, -34, -52, -31, -63, -47, -65,   9,  22,  20,  69, -46, -86, -65;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='L';  M= -66, -72, -85, -79,  22, -86, -73,  62, -77,  65,  28, -79, -79, -73, -77, -74, -31, -12, -69, -50;
/M: SY='F';  M= -69, -70, -86, -79,  89, -84, -68, -37, -77,  57,  24, -79, -84, -78, -75, -74, -63,  11, -55, -34;
/M: SY='R';  M= -28, -79,   0, -50, -76, -72, -54, -79,  -7, -74, -64, -53, -72,  12, 102, -11,  17, -72, -78, -63;
/M: SY='G';  M=   6, -73,  -3,  12, -78,  64, -62, -77,  11, -77, -69,  30, -67, -54,  15,   3,  -5, -29, -79, -72;
/M: SY='N';  M= -61, -71,  34,  17, -79,  -8, -47, -78, -47, -81, -71, 104, -69,  -8,  -1, -17, -11, -77, -91, -71;
/M: SY='S';  M= -47,  22, -58, -59, -72, -58, -64, -68, -58, -72, -66, -48,  28, -56, -65,  80,  74, -60, -85, -68;
/M: SY='C';  M= -16,  57, -74, -69, -54, -74, -70,  16, -69,  53, -43, -68, -15,   8, -71,  18,  18,  15, -78, -61;
/M: SY='A';  M=  64, -66, -71, -67,  18, -61, -72,   2, -66, -30, -54,   1, -71, -65, -70,   5, -22,  42,  44, -58;
/M: SY='S';  M= -52, -68, -62, -62,  26, -30, -66,  -2, -12, -64, -62, -12,  13, -59, -64,  66,  59, -25,  50, -56;
/M: SY='K';  M= -17, -74, -56, -46, -75, -67, -57, -73,  83, -28, -62,   5, -65,  24,  35,  -3,  20, -68, -75, -65;
/M: SY='M';  M=  14,  40, -68, -66, -61, -66, -62,  26, -58,   6,  76,   2, -71, -58,  24,  41,  -1, -48, -78, -61;
/M: SY='M';  M= -64, -71, -82, -30,  31, -84, -70,  56, -74,  44,  77, -77, -77, -70, -74, -73, -60,  23, -70, -49;
/M: SY='E';  M= -59, -74,  33,  51,  19,  -2, -60,  -1, -58, -19, -58, -56, -67, -55, -64,  -6,  35,   8, -68,  41;
/M: SY='Q';  M= -16, -74,   0,  45,   1, -18, -57, -70,  32, -25,  -1, -52, -64,  61, -14,  21,  18, -67, -75, -62;
/M: SY='Y';  M= -43,  28,  -3, -70,  58, -78,   7,   5, -66,  -2,  14, -67, -80, -66,  -7, -50, -18, -54, -46,  94;
/M: SY='M';  M= -32, -69, -70, -70,  63, -73, -59, -46, -63,  19,  86,  36, -75, -64,  -8, -60,  32, -23, -64,  -1;
/M: SY='K';  M= -61, -75, -62, -52, -19, -20, -60, -62,  73,  -8, -58, -55, -70, -47,  62,  -5, -21,  12, -74, -61;
/M: SY='R';  M= -25, -73,  -5,  36, -61,  -8, -62, -13, -52,  41, -49, -13, -72, -53,  48,  -7, -21,   7, -78, -63;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='R';  M=  -6, -74, -68, -60,   0, -71, -62,  15, -21, -57, -55, -62,  27,  17,  50,  21,   0,  33, -70,  28;
/M: SY='G';  M=  32, -73, -60,  14, -81,  83, -67, -81, -62, -79, -70, -52, -66,   8, -69, -47,   4, -73, -75, -74;
/M: SY='Q';  M=   0, -73, -27, -27, -71, -22,   9, -31,  11, -40,  67,  22, -68,  69,  21,  -6,   6, -16, -78, -61;
/M: SY='Q';  M= -29, -76,  15,  28, -72, -68,  41, -12,  19, -19,  -1,  26,  26,  49, -15, -21,  -1,  -6, -81, -63;
/M: SY='Y';  M= -13, -77, -69,  -8,  50, -76,  25, -56, -65, -20, -51, -69, -79, -62, -64, -64, -17, -60, -37, 114;
/M: SY='L';  M= -67, -70, -85, -77,   8, -85, -70, -33, -78,  86, -31, -84, -84, -72, -75, -77, -64, -13,  45, -50;
/M: SY='H';  M= -61, -76, -27, -16,   0, -71,  70,   4,  45, -65, -58, -50, -67,  53,  30,  -7,  39, -63, -77, -55;
/M: SY='Q';  M=  28, -72,  16,  14, -22, -23,  11, -67,  42, -69, -63, -51, -65,  47, -16,  16,   9,  -3, -78, -63;
/M: SY='T';  M=  36, -66, -71, -69, -58, -71, -74,  47, -67,  13, -46, -63, -69, -67, -72, -51,  66,  25, -79, -62;
/M: SY='L';  M= -67, -70, -85, -78,  -7, -87, -71,  34, -78,  84, -30, -82, -83, -72, -76, -77, -63, -36, -70, -52;
/M: SY='G';  M=   6, -75,   1, -57, -73,  55,  51, -75,  31, -74, -65, -51, -68,  -9,  29,  13, -59, -16, -76,  -7;
/M: SY='P';  M=   3, -83,  28,  21, -84, -67, -62, -76,  29, -79, -69, -59,  95,  21,  -5, -57, -58, -75, -79, -74;
/M: SY='V';  M= -47,   7, -78, -74,  41, -32, -75,  40, -73,  12, -45, -72,  37, -73, -76,   0, -24,  53, -72, -53;
/M: SY='I';  M= -62, -72, -83, -78,  -9, -86,  16,  65, -76,  49, -35, -77, -79, -73, -76, -72, -58,  50, -75, -54;
/M: SY='M';  M= -28, -74,  34,   4, -69, -68, -57, -11,  48,   0,  49,  15, -68,  15,  27,   7, -19, -61, -79, -63;
/M: SY='E';  M= -16, -24,  21,  40, -71,  -3, -56, -16,  38, -70, -64,  28, -67,  25,  32, -55, -29, -13, -75,  11;
/M: SY='I';  M= -61, -71, -82, -79, -49, -85, -79,  71, -76,  37, -36, -15, -78, -74, -78, -71, -56,  60, -78, -58;
/M: SY='C';  M= -28,  57, -79, -76,  14, -78, -69,  51, -73,  18,  33, -72, -78, -71, -74,   6, -56,  37, -68,  36;
/M: SY='Q';  M=   7, -74,  49,  52, -76, -67, -57, -25,  -1, -38, -63,  -9, -64,  54, -55,   3,   0,   4, -82, -67;
/M: SY='S';  M= -55,  -9,  44,  52, -76, -61,   6, -74, -52, -18, -67,  41,   6,  -3, -59,  59, -50, -71, -86, -68;
/M: SY='K';  M= -26, -74,  19,  30, -77,  -6,  41, -73,  57, -74, -66,  19, -12, -46,   3,  22, -10, -15, -82, -65;
/M: SY='K';  M= -40, -77,  47,  43, -77, -68,  19, -69,  53, -37, -65,  -5, -10,  29, -22,   6, -56,   0, -82, -65;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='W';  M= -58, -74,  57, -51, -19, -60,  28, -41, -23, -73, -68,  56, -16,  -6, -60,  53, -51, -45,  67,  22;
/M: SY='C';  M= -65, 107, -84, -80,  62, -81, -73,   2, -77,  35,  33, -74, -85, -79, -78, -70, -62,  -1, -69, -48;
/M: SY='E';  M= -61, -80,  30, 101, -83, -73,   7, -84,   5, -77, -73,  -7, -58, -36, -50, -56, -60, -77, -83, -71;
/M: SY='I';  M= -57, -69, -75, -71, -53, -78, -74,  57, -70,  34, -41, -67, -73,  -6, -73,  14,  36,  44, -78, -59;
/M: SY='D';  M= -65, -78, 107, -11, -85, -62,   7, -84, -19, -83, -79,  35, -67, -52, -60,   3, -55, -81, -99, -69;
/M: SY='P';  M= -10, -87, -66, -55, -85, -66, -69, -73,  -7, -82, -70, -70, 121, -63, -70, -20, -57, -76, -79, -81;
/M: SY='S';  M=  -1,   9, -65, -64, -59, -67,  21,  12, -22,   2,   0,  12, -71, -20,   1,  38,  19,  32, -77,  12;
/M: SY='K';  M= -62, -77, -15, -12, -73, -71,   6, -76,  84, -38, -63, -50, -66,  20,  51, -21,  -7, -72, -73,  -6;
/I:         I=-7; MD=-19;
/M: SY='L';  M= -63,  48, -84, -79,  -8, -85, -77,  32, -78,  53,  10, -78, -82, -75, -78, -27, -30,  45, -78, -58; D=-7;
/I:         I=-7; MD=-19;
/M: SY='Y';  M= -84, -95, -22, -24,  -2, -51, -68,  -9, -31, -35,  17, -21, -94, -77, -24, -43, -25, -74, -66,  79; D=-7;
/I:         I=-7; MD=-19;
/M: SY='Q';  M= -15, -96, -23,   9, -95, -87, -77, -32,  26, -43, -80,   0, -87,  44, -21, -25, -77, -31, -98, -86; D=-7;
/I:         I=-7; MD=-19;
/M: SY='Q';  M= -13, -94, -17,  -9, -89, -49, -73, -95,  -2, -94, -86,  17, -88,  24,  14,  12, -32, -91, -93,  13; D=-7;
/I:         I=-7; MD=-19;
/M: SY='W';  M= -91,-101, -21, -32,  47, -36, -92,  21, -90, -37,   3, -93, -99, -91, -26, -93, -89, -72,  75,  -9; D=-7;
/I:         I=-7; MD=-19;
/M: SY='I';  M= -80, -94, -87, -33, -83, -95,  21,  25, -81, -39, -72,  -5, -94, -81,   0,   9, -16,  17,-105, -82; D=-7;
/I:         I=-7; MD=-19;
/M: SY='P';  M= -38,-101,  10, -78,-106,   0, -82,-104, -77,-106, -96,  35,  36, -19,  -1,  -5, -80,-102,-109, -98; D=-7;
/I:         I=-7; MD=-19;
/M: SY='Q';  M= -26,  10, -22,  17,  -4, -95,  19, -96,   2, -46, -86, -79, -92,  30, -22, -56, -27, -93,-100, -82; D=-7;
/I:         I=-7; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='E';  M= -86,  25, -20,  31,-107,  -5,  -7, -36, -30,-102, -96, -82, -95,   4, -86,   2, -86, -99,-111, -98; D=-7;
/I:         I=-7; DM=-19;
/M: SY='Q';  M= -22, -98, -32,  -4, -99, -13, -83, -37, -28, -35, -85, -17, -91,  42, -80,  17, -33, -89,-103, -91; D=-7;
/I:         I=-7; DM=-19;
/M: SY='A';  M=  32, -96, -21,  13, -22, -89, -90, -30, -29, -40, -84, -87,   2, -80, -26, -79, -82, -35,-100, -89; D=-7;
/I:         I=-7; DM=-19;
/M: SY='Q';  M= -45, -97, -87,   4, -23, -98,   7,   4, -28,   5,  15, -86, -94,  15, -22, -32, -82, -15, -97, -78; D=-7;
/I:         I=-7; DM=-19;
/M: SY='Q';  M= -50, -97,  13,  11,   0, -35, -73, -94, -69, -90, -85,  10, -89,  42,   3, -18, -21, -92, -91,   6; D=-7;
/I:         I=-7; DM=-19;
/M: SY='H';  M= -52, -97,  -4,  -5, -21, -91,  51, -84, -30, -12, -76, -17, -13,   4,  -3, -26, -46, -35, -96,  -6; D=-7;
/I:         I=-7; DM=-19;
/M: SY='P';  M= -21, -99, -20,  13, -98, -49, -79, -89,  -5, -61, -83, -31,  63,  29,  -8, -75, -77, -39, -97, -90; D=-7;
/I:         I=-7; DM=-19;
/M: SY='E';  M= -13, -79, -51,  61, -81, -71, -62, -76,  32, -77, -70,   2,  29, -48,  28,  10,  -4, -19, -83, -73; D=-7;
/I:         I=-7; DM=-19;
/M: SY='V';  M= -28, -71,  -1,  27, -65, -35, -69, -15,   9, -12, -54, -61,  27, -59, -63,   1,  26,  59, -83, -66;
/M: SY='Q';  M=  23, -73, -17,   1, -79,  16, -59, -76,  37, -76, -66,   8,  14,  41,  19,  29,  -6, -70, -78, -69;
/M: SY='E';  M=  -6, -73,  -3,  60, -78, -37, -54, -75,   1, -75, -68,  58, -34,  19,  13,  31, -15, -33, -82, -69;
/M: SY='M';  M= -16, -72,  28,   3,  -1, -67, -57,  -3,  26, -23,  49,  23, -69, -53,   4,  29, -15, -12, -72,  20;
/M: SY='L';  M= -32, -71, -78, -72,  28, -81,  20,  22, -66,  55, -39, -73, -80, -67,  18, -30, -60,  33, -68,   9;
/M: SY='E';  M=  23, -76,  26,  73, -76, -69, -59,  -4,  -3, -67, -64,  -7,   9,  11, -19, -55, -57,   6, -81, -70;
/M: SY='E';  M=  -7, -73,  31,  46, -74, -15, -58, -27,  19, -17, -64,  13,  -9,   9,  -4,  21,  24, -65, -81, -68;
/M: SY='N';  M= -28, -70, -47, -56, -73, -58,  46, -68, -47, -72,  -3,  92, -71,   8,  33,  25,  -3,  -8, -88, -64;
/M: SY='Q';  M= -25,  -5, -69,  -3, -12, -77, -63,  14, -15,  45,   9, -67, -74,  59,  -6, -24, -59,  20, -71,  -6;
/M: SY='R';  M=  29, -74,   5,  36, -77,   8,  -9, -75,  10, -71,  19, -13, -66,  20,  50,  11, -28, -68, -78, -66;
/M: SY='N';  M= -38,  27, -49,  -8, -72, -62,  12, -70,  42,  -1, -61,  79, -70,  17,   9,  11, -12, -69, -83, -65;
/M: SY='L';  M= -67,  10, -85, -77,   8, -85, -68, -34, -78,  87,  12, -82, -84, -71, -75, -77, -63, -41, -70, -51;
/M: SY='R';  M= -64, -76, -70, -26, -54, -79,  38,   1, -18,  25,  -7, -65, -76, -19,  66, -65, -18,  24,  51,  28;
/M: SY='Q';  M=  21, -72,  22,  -5, -71,   2,  25, -68,  21, -36,  20,  22, -67,  41, -10,  19, -21, -32, -77,   2;
/M: SY='Y';  M=  -6,  25, -75, -72,  19, -75,  42,  24, -69,  12,  42, -68, -77, -65, -69, -18,  -5,  -2,  50,  72;
/M: SY='C';  M= -13,  91, -77, -74, -17, -77, -76,  -1, -71,   4,  25, -68, -77, -73, -75, -59,  42,  58, -84, -63;
/M: SY='E';  M= -59, -77,  57,  62, -82, -14, -54, -78,   3, -77, -70,  24, -63,  50, -25,  10,   0, -47, -84, -69;
/M: SY='K';  M= -25, -75,   0,  34, -73, -41, -57, -66,  57, -23,  37,  -7, -28,  17,  35,  -3, -17, -19, -77, -65;
/M: SY='F';  M=   0, -69, -84, -78,  86, -80, -72,  15, -76,  31,  -2, -77, -81, -78, -75, -69, -61,  36, -58, -37;
/M: SY='W';  M= -17, -71, -85, -78,  66, -81, -73,  12, -76,  55, -40, -79, -81, -75, -75, -71, -29,  17,  77, -40;
/M: SY='E';  M= -57,  25,  39,  54, -72,  -3,  32, -71,   7, -38, -66,   4, -65, -16, -56,  27,  12, -19, -82,  -7;
/M: SY='A';  M=  52,  -9, -62, -59, -67,  -5, -60, -10,  26, -65,  20,  25, -68, -54,  15,  19,  -6, -31, -73,  14;
/M: SY='I';  M= -65, -75, -85, -81, -45, -88, -77,  91, -78,  36, -35, -78, -77, -74, -79, -74, -59,  12, -70,  13;
/M: SY='T';  M= -57, -14, -68, -63,   5, -72, -66,  44,  -5,  -8, -49, -59, -70,  32, -63,  31,  49,  19, -71,  17;
/M: SY='S';  M= -27, -73, -16, -19, -74, -21,  15, -27,  39, -34,   8,  38, -67,  47,  18,  48, -18, -67, -79, -63;
/M: SY='S';  M=   9, -65, -53, -56, -75, -51, -57, -72,  -6, -77, -69,  50, -14, -50, -59,  88,   7, -66, -83, -68;
/M: SY='S';  M=  -5, -69, -71, -69, -53, -28,  13,  17, -67,  18, -49, -63, -72, -63, -69,  47,   9,  42,  47,  22;
/M: SY='N';  M= -16,  25,  47,  10, -69, -26,  37, -67, -30, -70, -14,  49, -13, -53, -14,  33, -19,   0, -82,  14;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='C';  M= -38,  38,  18,  21, -66, -69,  -9, -19, -18,  -7,  30,  26, -70,  34,  26,   3,   7, -14,  23,  -9;
/M: SY='C';  M= -68,  83, -85, -81,  72, -84, -73,  47, -78,  39,   5, -76, -83, -79, -78, -73, -63, -41, -63, -43;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/M: SY='Y';  M=   3, -77,  14, -58, -54, -38,  43,  -7, -16, -47, -58, -59,  53, -58,  11,  -1,   8, -12, -63,  70;
/M: SY='E';  M=  -1, -73, -52,  47, -74,  32,  22, -39, -55, -39, -62,  22,   4,  36, -61,  17, -13,  11, -80, -67;
/M: SY='L';  M= -65, -71, -85, -78, -45, -85, -71,  55, -76,  67,  65, -79, -79, -70, -75, -75, -61,   5, -73, -54;
/M: SY='R';  M= -64,  65, -62, -55, -22, -24, -57, -77,  35, -73, -64,  13, -75, -46,  94, -59, -62, -35, -77, -64;
/M: SY='W';  M= -10, -80,  28,   4,  -8, -69, -59, -41, -62,   3, -58,   1, -74,   5, -65,  -1, -40, -66, 119,  69;
/M: SY='I';  M= -27,  -9, -80, -76, -52, -83, -80,  78, -74,  13, -39, -73, -75, -11, -76, -66,  12,  50, -78, -59;
/M: SY='C';  M=  24, 100, -81, -77,  70, -74, -72, -18, -74,  12, -51, -72, -82, -77, -76, -64, -60,   8, -64,   3;
/M: SY='K';  M=  10, -74, -18, -50, -15, -24,  37, -74,  61, -71, -63, -51, -67,  25,  38,  20,  -2, -69, -70,  21;
/M: SY='Q';  M= -35,  49,  27, -50, -71, -46, -58, -25,  -5, -35, -60,  10, -69,  75, -55,  34,  18,   7, -80, -10;
/M: SY='W';  M= -66, -74, -84, -79,  19, -20, -74,  55, -76,  60,  29, -78, -79, -72, -76, -73, -22, -37,  73, -48;
/M: SY='Y';  M= -33, -78, -65, -56,  48, -73,  -9, -68,  32, -62, -58, -59, -74,  36,  67, -11, -62, -67, -54,  69;
/M: SY='Q';  M= -29,  66,   2,  29, -76, -67, -55, -72,  23, -15, -62,  47, -69,  67,   9, -18, -17, -70, -81, -67;
/M: SY='S';  M=  15,  46, -64, -32, -64, -65, -62,  -2,   8, -33,  12, -56, -69,  15,  25,  47,  16,   2, -75,  11;
/M: SY='A';  M=  51,  49, -76, -70, -56, -69, -73, -11, -71,  46, -44, -71, -75, -68, -73, -57,   2,  38, -78, -63;
/M: SY='Q';  M=  22,  30, -56,  30, -69, -17,  22, -70, -11, -31, -61, -11, -68,  58,  21,  23, -28, -37, -73,  20;
/M: SY='E';  M= -19,  30,   3,  59, -76, -71,  33, -29,  27, -37, -62, -33, -66,  46,  38, -32, -22, -33, -80, -64;
/M: SY='R';  M= -62, -75, -60, -55, -62, -72,  20,  -2,  54, -22, -56,  24, -71, -16,  59,  -8, -22,  15, -72,  24;
/M: SY='F';  M= -33,  32, -17, -33,  92,  10,  -2, -54, -70, -16, -55,  14, -79, -73, -72, -28, -62,  -5,  37,  -5;
/M: SY='P';  M= -63, -83,  32, -52, -77, -36, -64,   4, -38, -39, -64, -59,  95,  -6,  37,   6, -17, -67, -80, -72;
/M: SY='D';  M= -19, -76,  66,  41, -78, -25,  22, -75,  -4, -22, -67,  24,   3,  23, -20,   8, -13, -73, -86, -67;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='D';  M=  21, -73,  44,  41, -71, -27,  36, -26,  19, -45,   6,  25, -66, -50, -55,  -4,  -4, -17, -81, -12;
/M: SY='Q';  M=   7, -72, -16,   5, -68, -31,  18,  14, -57,  -4, -10, -40,  22,  49, -30,  34,  22,  -8, -79, -63;
/M: SY='D';  M=  16, -74,  73,  12, -72,  -3,  38,   1,   5, -37, -64, -48, -67, -54, -60,  -6,   5, -30, -83, -12;
/M: SY='E';  M= -57, -75,  -7,  56, -68, -36, -63,  33, -56, -57,   9, -59,  15,  42, -61,  18,  -9,  32, -80, -65;
/I:         I=-16; MD=-41;
/M: SY='R';  M= -68, -82, -62,  33, -73, -80, -63,  10,   1,  -2, -60,   5, -75,  30,  59, -64,   1, -10, -83, -68; D=-16;
/I:         I=-16; MD=-41;
/M: SY='Y';  M= -32, -85, -79, -28, -58, -87,  21,  15, -68,  21, -56, -76, -86,   5,  22, -28, -18,  -5, -74,  50; D=-16;
/I:         I=-16; MD=-41;
/M: SY='K';  M= -80,   4, -87, -81,  -7, -91, -83, -79,  22,  12, -74, -80, -13, -77, -10,  19,  -6, -79, -91, -10; D=-16;
/I:         I=-16; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='A';  M=  67,   8, -74, -68, -60, -28, -73,   3, -69,  31, -47, -69, -73, -66, -72, -26, -54,  35, -77, -64;
/M: SY='V';  M= -29,  36, -84, -79, -52, -84, -81,  66, -76,   0,  28, -76, -77, -75, -78, -69, -55,  70, -81, -60;
/M: SY='S';  M= -11,  52, -61, -64, -76,  59, -66, -78,   0, -77, -70, -49, -67, -57, -64,  68,  15, -70, -80, -71;
/M: SY='S';  M=  19, -69,  28, -57, -71,  43, -59, -75, -11, -76, -69,  28, -67, -55, -62,  58,   2, -69, -76,  18;
/M: SY='F';  M= -15, -70,  -1, -72,  90, -74, -66,  -4, -72,  21,  32, -68, -78, -72, -72,  21, -59, -10, -57, -36;
/M: SY='I';  M= -62, -71, -85, -79,  -9, -86, -76,  60, -77,  52,  28, -79, -79, -73, -77, -73, -58,  51, -74, -54;
/M: SY='F';  M= -70,  13, -83, -80,  98, -82, -61, -18, -75, -10,   3, -76, -84, -79, -73, -71, -64,  16, -44,  67;
/M: SY='L';  M= -64, -71, -75, -73, -40, -77, -61, -40, -71,  70,   6,   2, -80, -66, -70,  -3,  -6,  -9,  45,  55;
/M: SY='R';  M=  -3, -78, -61, -53, -74, -72,  22, -74,   2, -72, -62,  13, -73, -44, 102, -57, -26, -15, -78, -62;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='F';  M= -74, -72, -84, -81, 109, -83, -62, -47, -76,  15, -47, -77, -85, -81, -73, -73, -67, -53, -41,  58;
/M: SY='F';  M= -66, -72, -86, -81,  72, -85, -73,  59, -77,  35,  33, -78, -80, -77, -77, -73, -61,  23, -61, -41;
/M: SY='C';  M=  30, 111, -60, -65, -75,   0, -64, -75, -62, -74, -68,  57, -75,  -8, -68,  33, -52, -66, -88, -74;
/M: SY='P';  M= -32, -86, -65,  -5, -80, -68, -69, -65, -62, -38, -66, -71, 117, -64, -73, -10, -57,  -5, -80, -79;
/M: SY='A';  M=  91, -63, -70, -62, -67, -53, -69,  -9, -64, -61, -57, -64, -68, -61, -68, -44, -53,   2, -72,  11;
/M: SY='I';  M= -64, -75, -86, -82, -48, -89, -81,  94, -78,  29,  11, -77, -76, -74, -80, -74, -59,  14, -74, -56;
/M: SY='V';  M= -34, -69, -82, -73, -50, -83, -74,  20, -73,  47,  35, -77, -79,   5, -73, -68, -56,  72, -79, -58;
/M: SY='S';  M=  21, -64, -53, -58, -73, -31, -58, -67, -56, -73, -66,  61, -66, -52, -62,  80,  20, -15, -85, -68;
/M: SY='P';  M= -19, -90, -67, -55, -85, -67, -69, -74, -60, -83, -70, -72, 123, -64,  -5, -62, -59, -77, -79, -82;
/M: SY='D';  M= -60, -78,  63,  47, -75, -66,  15, -80,  41, -76, -69,  -6, -64,  34,  -9,  23, -56, -76, -78,  13;
/M: SY='L';  M=  18, -70, -62,  10, -54, -26, -58, -52,   0,  48,  11,  25, -72,  13, -60,  -6,  -4, -54, -70,  28;
/M: SY='F';  M= -16, -72, -76,  -8, 102, -77, -60, -52, -71, -29, -52, -72, -81, -73, -70,  -6, -63, -28, -43,  64;
/M: SY='G';  M= -58, -77,  50,   0, -76,  61,  38, -81,  16, -78,   1,  46, -68,  -4, -58, -52, -60, -79, -80,  -7;
/M: SY='I';  M= -65, -74, -84, -80, -42, -87, -72,  75, -77,  58, -33, -79, -79, -72, -77, -74, -60,   6, -67,  29;
/M: SY='I';  M=  -6, -71, -76, -69, -54, -79, -71,  51,  -8,  29,  26, -69, -74, -64,  30, -64,   7,  41, -77, -59;
/M: SY='D';  M= -28, -76,  83, -10, -80, -26, -58, -33,  -3, -58, -71, -45,  37,   9, -60,  38,   7, -71, -88, -69;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='D';  M= -57, -76,  40,  27, -74,  32,  36, -27,  11, -68, -63,  -9, -67,  16,   7,   8, -57,  27, -83, -65;
/M: SY='H';  M=   0,   6, -52,   2, -66, -27,  80, -74,  -3, -47, -61,  51, -69,  31,  15,  18, -21, -71, -76,  32;
/M: SY='P';  M=   4, -77, -69, -62, -66, -71,  24,  28, -65,   4, -52,   1,  88,  -9, -71, -61, -16,  20, -80, -67;
/M: SY='D';  M=  -7, -72,  64, -50, -74,   4,   6,  -8, -58, -20, -64,  14,   7,  10, -64,  43,  23, -64, -85, -66;
/I:         I=-45; MD=-115;
/M: SY='P';  M=  24, -78,   4,  15, -79, -29, -68, -10, -25, -42, -68,   7,  65, -61, -69,   2,  30, -65, -85, -76; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='Q';  M= -28, -76,  -2,   0, -72, -23,   1,  13,   8, -25, -58,   3, -68,  60,  54,  -3,  24, -61, -78, -63;
/M: SY='T';  M=  19, -69, -20, -22, -68, -66, -64,  -4,  -8, -58,  19,  16,  16,  37, -61, -16,  57,  31, -82, -65;
/M: SY='R';  M=  34, -71, -56,  -2, -75, -61, -56, -40,   0, -72, -64,  35, -68,  17,  64,  36,  -8, -37, -79, -66;
/M: SY='R';  M= -66, -82, -60, -48, -76, -74,  55, -82,  47, -75, -63, -53, -72,  14,  98, -59, -64, -77, -77, -59;
/M: SY='N';  M= -56, -67, -49, -59,   3, -10,   6, -68,  -5, -71, -65,  82, -17, -55, -59,  18,  71, -65, -84, -63;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='L';  M= -67, -69, -85, -77,   9, -86, -69,   2, -78,  88, -29, -83, -84, -72, -75, -77, -63, -39, -69, -51;
/M: SY='T';  M=  -8, -69,  -1, -63, -60,   6, -65,  23,  -6,  -1,  26,   2, -69, -61,  -5, -52,  61,   9, -76,   7;
/M: SY='L';  M= -29, -70, -67, -62, -51, -72, -60,  -4, -63,  61, -41,  11, -74,  54, -64,  11,  20, -48, -71,  11;
/M: SY='I';  M= -62, -72, -85, -80, -47, -87, -78,  76, -77,  45,  28, -78, -78, -73, -78, -73, -58,  42, -75, -56;
/M: SY='A';  M=  74, -64, -65, -61, -68,  -7, -64, -62, -62, -65,  22, -57, -67, -57, -66,  53, -48, -13, -73,   9;
/M: SY='K';  M= -62, -77, -57, -44, -76, -69, -57, -75,  98, -72,  30, -50, -65,  16,  29, -11, -57, -72, -73, -64;
/M: SY='V';  M=  -6, -67, -75, -72, -54, -76, -75,  44, -70,  19,   8, -68, -73, -69, -73,   9,  35,  60, -80, -60;
/M: SY='L';  M= -64, -71, -84, -78, -45, -86, -73,  58, -77,  68,  25, -79, -79, -72, -76, -74, -31,  19, -74, -55;
/M: SY='Q';  M= -14, -80, -57, -38, -80, -67, -50, -68, -44,   1, -54, -52, -68, 122, -44,  -9, -60, -70, -72, -61;
/M: SY='N';  M= -26, -70, -48,  -8, -73, -59,  48, -37, -49, -69,  30,  78, -68,  37,  11,  33,  28, -67, -86, -62;
/M: SY='L';  M=  12, -70, -83, -76,  -9, -81, -74,  52, -76,  65, -34, -78, -79, -71, -76, -69, -59,  16, -72, -55;
/M: SY='A';  M=  71, -65, -68, -65,  54,  26, -68, -65, -65, -63, -62, -60, -69, -63, -69,  30, -54, -58, -67, -55;
/M: SY='N';  M= -27, -67, -45,  -5, -68, -56, -51, -64, -53,   8,   6,  97, -70, -52, -60,  43,   6, -65, -87, -67;
/M: SY='M';  M= -63,  16, -68, -68,  32,  20,  25,  13, -59,  21,  41,  32, -75, -18,  27, -61,  -1, -54,  39, -52;
/M: SY='K';  M=   7, -71,  17,  21, -74,  17, -63, -62,  46, -68, -63, -52, -65,  -5, -18,  23,  12,  25, -80, -68;
/M: SY='E';  M= -28,  -7, -55,  41,  20, -68, -59, -62,  16,   4,   4,   5,  25,  31, -27,  25,  13, -30, -74, -60;
/M: SY='F';  M= -65,  21, -26,  23,  97, -36, -62, -59, -65, -36, -57,   5, -10,   8, -67,  16, -60, -61, -55, -35;
/I:         I=-28; MD=-70;
/M: SY='G';  M= -17, -78,  -6,  21, -23,  35, -69, -33, -22, -19, -69, -59, -72,   9, -34,  32,  21, -44, -83, -72; D=-28;
/I:         I=-28; MD=-70;
/M: SY='S';  M= -25, -84, -67,  -3, -27,  43, -72, -89, -37, -89, -81,  15,  27, -65, -11,  45, -63, -84, -88, -80; D=-28;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='K';  M= -62, -79,  19, -12, -82, -68, -58, -81,  83, -81, -70,   5,  14,  25, -10,  18, -56, -77, -79, -69; D=-28;
/I:         I=-28; DM=-70;
/M: SY='E';  M= -60, -78,  27,  92, -78, -71, -55, -78,  -6, -29, -70,  13,  -8, -40, -54,  -6, -18, -74,  24, -69;
/M: SY='E';  M=   2, -77,  11,  48, -76,   7,   5, -31, -17, -17, -64,  15,  43,   7,  17,   2, -29, -68, -80, -68;
/M: SY='W';  M= -35, -78, -73, -70,  66, -76,  83, -25, -68, -28, -53, -22, -78, -66, -66, -66, -18,  -4,  97,  66;
/M: SY='M';  M= -64, -71, -22, -66,  17, -78, -59, -41,   9,  50, 105, -68, -75,   7, -15, -69, -31, -47, -70, -50;
/M: SY='E';  M=   2,  37,   1,  38, -71, -25, -61, -23,   5, -23,   1,  -3, -68,  -3,  30,  26, -19,  11, -81, -66;
/M: SY='P';  M= -46,   3, -27,  -3,  50,  -8, -65, -24, -24, -63,  18, -21,  78, -62, -20,  29, -25, -28, -70, -56;
/M: SY='M';  M= -65, -70, -78, -12,  44, -81, -64, -12, -30,  59,  85, -75, -77, -13, -68, -72, -62,  -1, -67, -47;
/M: SY='N';  M= -60, -70, -44, -23,  -4, -22,  10, -70, -21, -16, -63, 101, -72,  19, -56,  19, -50, -71, -79,  11;
/M: SY='E';  M= -61, -79,  44,  52, -79, -29, -56, -73,  30, -27, -66,  13,  41,  46, -22, -24, -37, -31, -81, -69;
/M: SY='F';  M= -70,  36, -81, -77,  94, -79, -60, -52, -39, -45,  54, -72, -81, -74, -70, -68,   2, -56,  61,  65;
/M: SY='I';  M= -16, -72,  -1, -72,  23, -82, -72,  50, -69,  50, -39, -73, -78, -70,   3, -69, -59,  34, -72, -53;
/M: SY='K';  M= -60, -10,   0,  40, -72, -16, -24, -12,  47, -16,  19,  44, -66,   4,   3,   0,   2, -64, -80, -66;
/M: SY='E';  M= -14, -73,   0,  57, -76, -20,   4, -70,   0, -46, -64, -51, -63,  48, -26,  45,  24, -18, -81, -66;
/M: SY='H';  M= -58,  63, -51,  37, -70, -24,  70, -12, -18, -69, -63,  42, -68,  -3, -18,  27,  24, -66, -84,  -6;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='W';  M= -14, -72, -65, -22,  15,   3,  28, -19,  38, -59,  23, -58, -69, -57, -56,  20,  24,  18,  62,  21;
/M: SY='D';  M=  10, -76,  52,  42, -79,  -7,  27, -41, -53, -39, -66, -10,  37,  38, -60,  12, -11, -70, -83, -68;
/M: SY='D';  M=  31, -73,  44,   4, -73, -48,  24, -24,  30, -47,  30,  -2, -67,   0,  32, -28,  -4, -30, -81, -64;
/M: SY='M';  M= -13, -69, -82, -76,  42, -79, -69,  36, -72,  -4,  93, -73, -75, -70, -72, -66,  -7,  50, -70, -49;
/M: SY='K';  M= -32, -76,   7, -50,   2, -72,   6, -20,  59,  -6,  17, -55, -70,  34,  51, -25, -60, -15, -71,  -5;
/M: SY='D';  M=   8, -19,  60, -46, -75, -62,  19, -73,  18, -28,   7,  36, -69,  23,  34,  25, -54, -70, -84, -64;
/M: SY='F';  M= -69, -73, -83, -80,  94, -83, -62,  16, -75,   4,  19, -76, -83, -77, -73, -72, -63,  15, -46,  63;
/M: SY='L';  M= -67, -70, -85, -79,  49, -86, -71,  36, -78,  73, -33, -81, -82, -74, -76, -76, -62,  -1, -65, -46;
/M: SY='D';  M= -31, -76,  61,  23, -64, -69,   6,  -6, -31,   0, -15,   5,   2,  25, -18,   4, -28,  -5, -77,  24;
/M: SY='E';  M= -61, -78,  20,  61, -76, -12, -55, -39,  25, -19, -63,  20, -65,  51,  26, -55, -11, -30, -79, -67;
/M: SY='I';  M=  18, -71, -76, -71, -53, -13, -71,  59, -26,  43,   7, -12, -75,   5, -70, -63, -58,  12, -75, -59;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	57 in 57 different sequences
Number of true positive hits	57 in 57 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Ras-GAP
Version [info]	8

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

57 sequences

BUD2_CANAL  (Q5A506), BUD2_YEAST  (P33314), DAB2P_HUMAN (Q5VWQ8),

DAB2P_MOUSE (Q3UHC7), DAB2P_RAT   (Q6P730), GAP1_CAEEL  (Q22720), 
GAP1_DROME  (P48423), GAP1_SCHPO  (P33277), GAP2_CAEEL  (Q8MLZ5), 
GAP2_DROME  (Q8T498), GAPA_DICDI  (O00899), GAPD1_BOVIN (A5D794), 
GAPD1_HUMAN (Q14C86), GAPD1_MOUSE (Q6PAR5), GAPD1_XENLA (A2RV61), 
IQG1_CANAL  (Q5AH02), IQG1_SCHPO  (O14188), IQG1_YEAST  (Q12280), 
IQGA1_HUMAN (P46940), IQGA1_MOUSE (Q9JKF1), IQGA2_HUMAN (Q13576), 
IQGA2_MOUSE (Q3UQ44), IQGA3_HUMAN (Q86VI3), IRA1_YEAST  (P18963), 
IRA2_YEAST  (P19158), NF1_HUMAN   (P21359), NF1_MOUSE   (Q04690), 
NF1_RAT (P97526), NFAA_DICDI  (Q55AR6), NGAP_DICDI  (Q54Y08), 
NGAP_HUMAN  (Q9UJF2), RAS4B_HUMAN (C9J798), RASA1_BOVIN (P09851), 
RASA1_HUMAN (P20936), RASA1_RAT   (P50904), RASA2_HUMAN (Q15283), 
RASA2_MOUSE (P58069), RASA2_RAT   (Q63713), RASA3_BOVIN (Q28013), 
RASA3_HUMAN (Q14644), RASA3_MOUSE (Q60790), RASA3_RAT   (Q9QYJ2), 
RASL1_HUMAN (O95294), RASL1_MOUSE (Q9Z268), RASL2_HUMAN (O43374), 
RASL2_MOUSE (Q6PFQ7), RASL3_BOVIN (A6QQ91), RASL3_HUMAN (Q86YV0), 
RASL3_MOUSE (Q8C2K5), RGAA_DICDI  (Q54K32), RME6_CAEBR  (A8WVM4), 
RME6_CAEEL  (Q9GYH7), RME6_DROME  (Q9VZ08), RME6_DROPS  (Q29HW3), 
SYGP1_HUMAN (Q96PV0), SYGP1_MOUSE (F6SEU4), SYGP1_RAT   (Q9QUH6)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

28 PDB

1NF1; 1WER; 1WQ1; 3BXJ; 3FAY; 5CJP; 6OB2; 6OB3; 6V65; 6V6F; 7MOC; 7MP5;
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