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PROSITE entry PS50007


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50007
Entry name [info] PIPLC_X_DOMAIN
Accession [info] PS50007
Entry type [info] MATRIX
Date [info] 01-NOV-1995 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50007
Associated ProRule [info] PRU00270

Name and characterization of the entry

Description [info] Phosphatidylinositol-specific phospholipase X-box domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ARNDCQEGHILKMFPSTWYVBZX';LENGTH=145;TOPOLOGY=LINEAR;
/DISJOINT: DEFINITION=PROTECT;N1=5;N2=140;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.2066000; R2=0.0157000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6183.6674805; R2=11.3997993; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=465; H_SCORE=11485; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=338; H_SCORE=10037; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: MI=-105; MD=-105; IM=-105; DM=-105; I=-20; D=-20;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 110 in 110 different sequences
Number of true positive hits 96 in 96 different sequences
Number of 'unknown' hits 0
Number of false positive hits 14 in 14 different sequences
Number of false negative sequences 1
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 87.27 %
Recall (true positives / (true positives + false negatives)) 98.97 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] PI-PLC X-box
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
96 sequences

B2KB1_SICCD (C0JB71), B2KB6_SICCD (C0JB80), DYAD_ARATH  (Q9FGN8), 
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UniProtKB/Swiss-Prot
False negative sequences
1 sequence

Y3730_DICDI (Q54BH5)

		
UniProtKB/Swiss-Prot
False positive sequences
14 sequences

ACAP1_HUMAN (Q15027), ACAP1_MOUSE (Q8K2H4), DCL1_ASPFU  (Q4WVE3), 
» more

PDB
[Detailed view]
61 PDB

1AOD; 1DJG; 1DJH; 1DJI; 1DJW; 1DJX; 1DJY; 1DJZ; 1GYM; 1PTD; 1PTG; 1QAS;
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