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PROSITE entry PS50003


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS50003
Entry name [info] PH_DOMAIN
Accession [info] PS50003
Entry type [info] MATRIX
Date [info] 01-NOV-1995 CREATED;
13-FEB-2019 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50003
Associated ProRule [info] PRU00145

Name and characterization of the entry

Description [info] PH domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=104;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=99;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6564000; R2=0.0227000; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2251.5849609; R2=6.5971980; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=1; SCORE=302; H_SCORE=4244; N_SCORE=8.5; MODE=1; TEXT='!!';
/CUT_OFF: LEVEL=0; SCORE=223; H_SCORE=3723; N_SCORE=6.7; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=192; H_SCORE=3518; N_SCORE=6.0; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 1'033 in 923 different sequences
Number of true positive hits 1'032 in 922 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 141
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.90 %
Recall (true positives / (true positives + false negatives)) 87.98 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 4
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] PH
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
922 sequences

3BP2_HUMAN  (P78314), 3BP2_MOUSE  (Q06649), AB1IP_CHICK (Q5ZL23), 
» more

UniProtKB/Swiss-Prot
False negative sequences
141 sequences

ADRM1_CAEEL (Q09289), ADRM1_DROME (Q7K2G1), ALS2_HUMAN  (Q96Q42), 
» more

UniProtKB/Swiss-Prot
False positive sequences
1 sequence

RL23_GEOMG  (Q39Y04)

		
PDB
[Detailed view]
325 PDB

1AWE; 1B55; 1BAK; 1BTK; 1BTN; 1BWN; 1DBH; 1DRO; 1DYN; 1EAZ; 1F7C; 1FAO;
» more