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PROSITE entry PS50002


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PURL: https://purl.expasy.org/prosite/signature/PS50002

Direct ScanProsite submission
General information about the entry

Entry name [info] SH3
Accession [info] PS50002
Entry type [info] MATRIX
Date [info] 01-NOV-1995 CREATED;
22-NOV-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50002
Associated ProRule [info] PRU00192

Name and characterization of the entry

Description [info] Src homology 3 (SH3) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=61;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=61;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3910916; R2=0.0092440; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1040; N_SCORE=12.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=445; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-51; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
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Post-processing [info]

COMPETES_HIT_WITH PS51781

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 1'294 in 1'009 different sequences
Number of true positive hits 1'294 in 1'009 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 1
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.92 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 6
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] SH3
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
1009 sequences

ABI1_HUMAN  (Q8IZP0), ABI1_MOUSE  (Q8CBW3), ABI1_RAT(Q9QZM5), 
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UniProtKB/Swiss-Prot
False negative sequences
1 sequence

ACK_DROME   (Q9VZI2)

		
UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

SRBS1_RAT   (P84109)

		
PDB
[Detailed view]
801 PDB

1A0N; 1ABO; 1ABQ; 1AD5; 1AEY; 1AOJ; 1ARK; 1AVZ; 1AWJ; 1AWO; 1AWW; 1AWX;
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