PROSITE entry PS01173

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General information about the entry

Entry name [info]	LIPASE_GDXG_HIS
Accession [info]	PS01173
Entry type [info]	PATTERN
Date [info]	01-NOV-1997 CREATED; 01-APR-2006 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00903

Name and characterization of the entry

Description [info]	Lipolytic enzymes "G-D-X-G" family, putative histidine active site.
Pattern [info]	[LIVMF](2)-x-[LIVMF]-H-G-G-[SAG]-[FYW]-x(3)-[STDN]-x(1,2)-[STYA]-[HAGFT].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	51 in 51 different sequences
Number of true positive hits	51 in 51 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	44
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	53.68 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site(?) at position 4
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

51 sequences

AAAD_MOUSE  (Q99PG0), AAAD_RAT(Q9QZH8), AES_ECO24   (A7ZIN6),

AES_ECO27   (B7UKF6), AES_ECO45   (B7MDZ8), AES_ECO55   (B7L7A1), 
AES_ECO57   (Q8XD38), AES_ECO5E   (B5Z3Y7), AES_ECO7I   (B7NIF4), 
AES_ECO81   (B7MQJ1), AES_ECO8A   (B7M3W8), AES_ECOBW   (C4ZUT0), 
AES_ECODH   (B1XFR3), AES_ECOHS   (A7ZXD4), AES_ECOK1   (A1A8E2), 
AES_ECOL5   (Q0TKG5), AES_ECOL6   (Q8FK82), AES_ECOLC   (B1IZB8), 
AES_ECOLI   (P23872), AES_ECOLU   (B7N929), AES_ECOSE   (B6I0B9), 
AES_ECOSM   (B1LJN4), AES_ECOUT   (Q1RF59), AES_SHIB3   (B2U4S9), 
AES_SHIBS   (Q325C0), AES_SHIF8   (Q0T7A9), AES_SHIFL   (Q83M39), 
AES_SHISS   (Q3Z4S3), BAH_STRHY   (Q01109), CXE16_ARATH (Q8LED9), 
CXE1_ACTER  (Q0ZPV7), CXE1_PAPSO  (I3PLR2), CXE2_ARATH  (Q9SX78), 
CXE2_PAPSO  (A0A0A1EQ07), CXE8_ARATH  (O64640), ESTZ_PSEPU  (Q8KQK1), 
EST_ACIVR   (P18773), FGL4_GIBZE  (I1RHF8), GID1A_ARATH (Q9MAA7), 
GID1B_ARATH (Q9LYC1), GID1C_ARATH (Q940G6), GID1_ORYSJ  (Q6L545), 
HIDH_SOYBN  (Q5NUF3), LIP2_MORS1  (P24484), LIPI_MYCTU  (P71668), 
LIPS_BOVIN  (P16386), LIPS_HUMAN  (Q05469), LIPS_ICTTR  (Q9R101), 
LIPS_MOUSE  (P54310), LIPS_PIG(Q68J42), LIPS_RAT(P15304)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

44 sequences

AAAD_HUMAN  (P22760), AAAD_RABIT  (Q7M370), AD4F1_MOUSE (Q8BM81),

ADCL2_HUMAN (Q6P093), ADCL3_HUMAN (Q5VUY0), ADCL3_MOUSE (A2A7Z8), 
ADCL4_HUMAN (Q5VUY2), AES_SALA4   (B5EXN3), AES_SALCH   (Q57S73), 
AES_SALDC   (B5FLK0), AES_SALEP   (B5QU79), AES_SALNS   (B4SWY4), 
AES_SALPA   (Q5PFJ2), AES_SALPB   (A9MW81), AES_SALPK   (B5BD42), 
AES_SALSV   (B4TMG8), AES_SALTI   (Q8Z8T1), AES_SALTY   (Q8ZRA1), 
CXE11_ARATH (Q9LK21), CXE12_ARATH (Q9SMN0), CXE13_ARATH (Q9SMM9), 
CXE15_ARATH (Q9FG13), CXE17_ARATH (Q9LFR7), CXE18_ARATH (Q9LT10), 
CXE1_ARATH  (Q9LMA7), CXE20_ARATH (Q9LVB8), CXE3_ARATH  (Q9FX92), 
CXE4_ARATH  (Q9FX93), CXE5_ARATH  (Q9FX94), CXE6_ARATH  (Q9SX25), 
CXE7_ARATH  (Q9ZQ91), CXE9_ARATH  (O64641), LIPC_MYCTU  (P96402), 
LIPM_MYCTU  (Q50681), LIPN_MYCTU  (P95125), LIPQ_MYCTU  (I6Y9F7), 
LIPR_MYCTO  (P9WK84), LIPR_MYCTU  (P9WK85), LIPU_MYCTU  (O53424), 
LIPY_MYCTU  (I6Y2J4), MLHB_RHOER  (Q9EX73), NCEH1_HUMAN (Q6PIU2), 
NCEH1_MOUSE (Q8BLF1), NCEH1_PONAB (Q5R8Y5)

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PDB
[Detailed view]

8 PDB

2O7R; 2O7V; 2ZSH; 2ZSI; 3EBL; 3ED1; 4KRX; 4KRY