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PROSITE entry PS00708


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PURL: https://purl.expasy.org/prosite/signature/PS00708

Direct ScanProsite submission
General information about the entry

Entry name [info] PRO_ENDOPEP_SER
Accession [info] PS00708
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-DEC-1992 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00587
Associated ProRule [info] PRU10084

Name and characterization of the entry

Description [info] Prolyl endopeptidase family serine active site.
Pattern [info]
D-x(3)-A-x(3)-[LIVMFYW]-x(14)-G-x-S-x-G-G-[LIVMFYW](2).

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 57 in 57 different sequences
Number of true positive hits 50 in 50 different sequences
Number of 'unknown' hits 1
Number of false positive hits 6 in 6 different sequences
Number of false negative sequences 71
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 89.29 %
Recall (true positives / (true positives + false negatives)) 41.32 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
50 sequences

AARE1_ORYSJ (Q0IXP9), AARE2_ORYSJ (Q338C0), ACPH_BOVIN  (P80227), 
» more

UniProtKB/Swiss-Prot
False negative sequences
71 sequences

AARE_ARATH  (Q84LM4), APEH_AERPE  (Q9YBQ2), CGEP_ARATH  (Q8VZF3), 
» more

UniProtKB/Swiss-Prot
'Unknown' sequences
1 sequence

YTAP_BACSU  (O34973)

		
UniProtKB/Swiss-Prot
False positive sequences
6 sequences

AR1AA_XENLA (Q8AVT9), AR1AB_XENLA (A0A1L8EXB5), NAR1_MYCMD  (Q4PAR1), 
» more

PDB
[Detailed view]
154 PDB

1E5T; 1H2W; 1H2X; 1H2Y; 1J2E; 1N1M; 1NU6; 1NU8; 1O6F; 1O6G; 1ORV; 1ORW;
» more