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PROSITE entry PS00697


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PURL: https://purl.expasy.org/prosite/signature/PS00697

Direct ScanProsite submission
General information about the entry

Entry name [info] DNA_LIGASE_A1
Accession [info] PS00697
Entry type [info] PATTERN
Date [info] 01-DEC-1992 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00295
Associated ProRule [info] PRU10135

Name and characterization of the entry

Description [info] ATP-dependent DNA ligase AMP-binding site.
Pattern [info] 
[EDQH]-{K}-K-{VEDI}-[DN]-G-{GLYN}-R-[GACIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 209 in 204 different sequences
Number of true positive hits 157 in 157 different sequences
Number of 'unknown' hits 0
Number of false positive hits 52 in 47 different sequences
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 75.12 %
Recall (true positives / (true positives + false negatives)) 91.28 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 4
Site [info] active_site(?) at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 157 sequences 

DNLI1_ARATH (Q42572), DNLI1_CAEEL (Q27474), DNLI1_DICDI (Q869E1),
» more

UniProtKB/Swiss-Prot
False negative sequences		 15 sequences 

DNLI1_RAT   (Q9JHY8), DNLI1_THEPD (A1RXA6), DNLI_HAEIN  (P44121),
» more

UniProtKB/Swiss-Prot
False positive sequences		 47 sequences 

ACVS_AMYLA  (P27743), ACVS_STRCL  (Q01757), ALN_ORYSJ   (B9FDB8),
» more

PDB
[Detailed view]		 54 PDB

1A0I; 1X9N; 2CFM; 2HIV; 2HIX; 3GDE; 3L2P; 3VNN; 3W1B; 3W1G; 3W5O; 6BKF;
» more