PROSITE logo

PROSITE entry PS00639


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00639
Entry name [info] THIOL_PROTEASE_HIS
Accession [info] PS00639
Entry type [info] PATTERN
Date [info] 01-JUN-1992 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00126
Associated ProRule [info] PRU10089

Name and characterization of the entry

Description [info] Eukaryotic thiol (cysteine) proteases histidine active site.
Pattern [info] 
[LIVMGSTAN]-{IEVK}-H-[GSACE]-[LIVM]-{GPSI}-[LIVMAT](2)-G-{SLAG}-[GSADNH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 486 in 483 different sequences
Number of true positive hits 245 in 245 different sequences
Number of 'unknown' hits 0
Number of false positive hits 241 in 238 different sequences
Number of false negative sequences 92
Number of 'partial' sequences 24
Precision (true positives / (true positives + false positives)) 50.41 %
Recall (true positives / (true positives + false negatives)) 72.70 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 3
Site [info] active_site at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 245 sequences 

4HBS_VANPL  (P0DO76), ACTN_ACTCC  (P00785), ACTN_ACTDE  (A5HII1),
» more

UniProtKB/Swiss-Prot
False negative sequences		 92 sequences 

361L_IIV6   (Q91FG3), BLMH_CHICK  (P87362), BLMH_HUMAN  (Q13867),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 24 sequences 

BLMH_RABIT  (P13019), CAL1_CALGI  (P20728), CAN1_RABIT  (P06815),
» more

UniProtKB/Swiss-Prot
False positive sequences		 238 sequences 

3HBH1_AQUAC (Q9F131), ACD10_HUMAN (Q6JQN1), ACD10_MOUSE (Q8K370),
» more

PDB
[Detailed view]		 396 PDB

1A6R; 1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO;
» more