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PROSITE entry PS00533


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PURL: https://purl.expasy.org/prosite/signature/PS00533

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General information about the entry

Entry name [info] PORPHOBILINOGEN_DEAM
Accession [info] PS00533
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00461

Name and characterization of the entry

Description [info] Porphobilinogen deaminase cofactor-binding site.
Pattern [info] 
E-[KR]-x-[LIVMFAT]-x(3)-[LIVMFAC]-x-[GSALV]-[GSANHD]-C-x-[IVTACS]-[PLA]-
[LIVMF]-[GSA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 444 in 444 different sequences
Number of true positive hits 444 in 444 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 31
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.47 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] cofactor_binding at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 444 sequences 

HEM31_STRAW (Q82E76), HEM31_STRCO (Q9WX16), HEM32_STRAW (Q82P95),
» more

UniProtKB/Swiss-Prot
False negative sequences		 31 sequences 

HEM3_ACET2  (A3DIF0), HEM3_ACIF2  (B7JBH8), HEM3_ACIF5  (B5ERN6),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

HEM3_DICCH  (P40129), HEM3_YERIN  (P30527)


				
	

	

		PDB
[Detailed view]		
		
			18 PDB
			


			1AH5; 1GTK; 1PDA; 1YPN; 2YPN; 3ECR; 3EQ1; 4HTG; 5H6O; 5M6R; 5M7F; 7AAJ; 
			
			

			» more