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PROSITE entry PS00533


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General information about the entry

Entry name [info] PORPHOBILINOGEN_DEAM
Accession [info] PS00533
Entry type [info] PATTERN
Date [info] 01-DEC-1991 CREATED;
01-DEC-2004 DATA UPDATE;
27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00461

Name and characterization of the entry

Description [info] Porphobilinogen deaminase cofactor-binding site.
Pattern [info] 
E-[KR]-x-[LIVMFAT]-x(3)-[LIVMFAC]-x-[GSALV]-[GSANHD]-C-x-[IVTACS]-[PLA]-
[LIVMF]-[GSA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.


Total number of hits 444 in 444 different sequences
Number of true positive hits 444 in 444 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 31
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.47 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] cofactor_binding at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 444 sequences 

HEM31_STRAW (Q82E76), HEM31_STRCO (Q9WX16), HEM32_STRAW (Q82P95), 

HEM32_STRCO (Q9KY00), HEM3_ACIAD  (Q6FFA9), HEM3_ACIC1  (A0LRF1), 
HEM3_ACTSZ  (A6VL87), HEM3_AERPE  (Q9Y9J0), HEM3_AGRFC  (Q8UC46), 
HEM3_ALCBS  (Q0VM28), HEM3_ALIB4  (A8ERI4), HEM3_ALIF1  (Q5E8T5), 
HEM3_ALIFM  (B5FF97), HEM3_ALISL  (B6EPK1), HEM3_ALKEH  (Q0A577), 
HEM3_ALKMQ  (A6TJD5), HEM3_ALKOO  (A8MGE4), HEM3_AQUAE  (O66621), 
HEM3_ARATH  (Q43316), HEM3_ARCFU  (O29026), HEM3_BACAA  (C3P9E9), 
HEM3_BACAC  (C3L6Z5), HEM3_BACAH  (A0RJ81), HEM3_BACAN  (Q81LC7), 
HEM3_BACC0  (B7JQ57), HEM3_BACC1  (Q72ZW2), HEM3_BACC2  (B7IIX5), 
HEM3_BACC3  (C1ETR0), HEM3_BACC4  (B7HE96), HEM3_BACC7  (B7HQM4), 
HEM3_BACCN  (A7GTE5), HEM3_BACCQ  (B9IZ39), HEM3_BACCR  (Q817R0), 
HEM3_BACCZ  (Q633Y0), HEM3_BACHK  (Q6HD62), HEM3_BACLD  (Q65GK1), 
HEM3_BACMK  (A9VIT8), HEM3_BACP2  (A8FFV2), HEM3_BACSU  (P16616), 
HEM3_BACVZ  (A7Z7A5), HEM3_BAUCH  (Q1LU25), HEM3_BORBR  (Q7WKM1), 
HEM3_BORPA  (Q7W785), HEM3_BORPD  (A9IKF3), HEM3_BORPE  (Q7VVU9), 
HEM3_BOVIN  (Q2KIN5), HEM3_BREBN  (C0ZAH1), HEM3_BRUA1  (B2S842), 
HEM3_BRUA2  (Q2YLM5), HEM3_BRUA4  (A6WXJ2), HEM3_BRUAB  (Q57B08), 
HEM3_BRUC2  (A9M8M2), HEM3_BRUMB  (C0RFD1), HEM3_BRUME  (Q8YJB0), 
HEM3_BRUO2  (A5VSL5), HEM3_BRUSI  (B0CID9), HEM3_BRUSU  (Q8FYI6), 
HEM3_BUCA5  (B8D8F3), HEM3_BUCAI  (P57651), HEM3_BUCAT  (B8D8B0), 
HEM3_BURCJ  (B4E8C4), HEM3_BURCM  (Q0BCU9), HEM3_BURM7  (A3MLK5), 
HEM3_BURM9  (A2SAH5), HEM3_BURMA  (Q62LC0), HEM3_BURMS  (A1V5U0), 
HEM3_BURO0  (B1JWR0), HEM3_BURP0  (A3NSN6), HEM3_BURP1  (Q3JUW3), 
HEM3_BURP6  (A3N700), HEM3_BURPS  (Q63W73), HEM3_BURTA  (Q2T071), 
HEM3_BURVG  (A4JGV4), HEM3_CALMQ  (A8MDU3), HEM3_CAMC1  (A7ZD37), 
HEM3_CAMC5  (A7GYU4), HEM3_CAMFF  (A0RNT3), HEM3_CAMHC  (A7I1S0), 
HEM3_CAMJ8  (A8FKW8), HEM3_CAMJD  (A7H4J7), HEM3_CAMJE  (Q9PHW9), 
HEM3_CAMJJ  (A1VYQ4), HEM3_CAMJR  (Q5HVM1), HEM3_CAMLR  (B9KGA9), 
HEM3_CANAL  (O94048), HEM3_CANGA  (Q6FNR4), HEM3_CARHZ  (Q3ACT3), 
HEM3_CAUSK  (B0T287), HEM3_CAUVC  (Q9ABZ8), HEM3_CAUVN  (B8GXG1), 
HEM3_CHLCH  (Q3AQF5), HEM3_CHLL2  (B3EIN1), HEM3_CHLL3  (Q3B2Z5), 
HEM3_CHLP8  (P28464), HEM3_CHLPB  (B3EPK0), HEM3_CHLPD  (A1BHD6), 
HEM3_CHLPM  (A4SFJ8), HEM3_CHLT3  (B3QWI1), HEM3_CHLTE  (Q8KCJ4), 
HEM3_CHRVO  (Q7P207), HEM3_CITBB  (B5EBG8), HEM3_CLOB8  (A6LSY5), 
HEM3_CLOBA  (B2UXC4), HEM3_CLOBB  (B2TPD7), HEM3_CLOD6  (Q180R9), 
HEM3_CLOK1  (B9DZL6), HEM3_CLONN  (A0Q2B1), HEM3_CLOP1  (Q0TQG4), 
HEM3_CLOPE  (Q8XKG4), HEM3_CLOPS  (Q0ST16), HEM3_COLP3  (Q48AW8), 
HEM3_CORA7  (C3PKG2), HEM3_CORDI  (Q6NJK0), HEM3_COREF  (Q8FSF7), 
HEM3_CORGB  (A4QB59), HEM3_CORGL  (Q8NT90), HEM3_COXB1  (B6J6K0), 
HEM3_COXB2  (B6J3T6), HEM3_COXBN  (A9KDC4), HEM3_COXBR  (A9N910), 
HEM3_COXBU  (Q83A37), HEM3_CROS8  (A7MQJ1), HEM3_CUTAK  (Q6AB05), 
HEM3_DEBHA  (Q6BM23), HEM3_DECAR  (Q479S8), HEM3_DEIDV  (C1CYD9), 
HEM3_DEIGD  (Q1J288), HEM3_DEIRA  (Q9RRY0), HEM3_DESAP  (B1I4L8), 
HEM3_DESHD  (B8G2M2), HEM3_DESHY  (Q24VC8), HEM3_DESRM  (A4J6H7), 
HEM3_DESVH  (Q72AV0), HEM3_DESVM  (B8DKW2), HEM3_DESVV  (A1VCX6), 
HEM3_DICDI  (Q54P93), HEM3_DICNV  (A5EW83), HEM3_ECO45  (B7MH66), 
HEM3_ECO55  (B7L959), HEM3_ECO57  (Q8XAP3), HEM3_ECO7I  (B7NTE0), 
HEM3_ECO81  (B7N295), HEM3_ECO8A  (B7M603), HEM3_ECOBW  (C4ZZ69), 
HEM3_ECODH  (B1XAH2), HEM3_ECOL6  (Q8FBP1), HEM3_ECOLI  (P06983), 
HEM3_ECOLU  (B7NFA7), HEM3_ECOSE  (B6I4E0), HEM3_EHRCJ  (Q3YSA8), 
HEM3_EHRCR  (Q2GGC7), HEM3_ENT38  (A4WG12), HEM3_EREGS  (Q75DY0), 
HEM3_ERWT9  (B2VG55), HEM3_ESCF3  (B7LU53), HEM3_EUGGR  (P13446), 
HEM3_EXIS2  (B1YJV1), HEM3_EXISA  (C4L4J6), HEM3_FRAP2  (B0TW04), 
HEM3_FRAT1  (Q14JI3), HEM3_FRATF  (A7N9H6), HEM3_FRATH  (Q2A5R3), 
HEM3_FRATM  (B2SE34), HEM3_FRATN  (A0Q481), HEM3_FRATO  (Q0BP15), 
HEM3_FRATT  (Q5NI31), HEM3_FRATW  (A4IZY4), HEM3_FUSNN  (Q8RFP5), 
HEM3_GEODF  (B9M416), HEM3_GEOKA  (Q5KWK6), HEM3_GEOMG  (Q39QM7), 
HEM3_GEOSL  (Q747I1), HEM3_GEOSM  (C6DYY8), HEM3_GEOSW  (C5D5K7), 
HEM3_GEOTN  (A4IRG5), HEM3_GEOUR  (A5GCW2), HEM3_GLOVI  (Q7NGF7), 
HEM3_HAHCH  (Q2SQ70), HEM3_HALH5  (Q9K8G0), HEM3_HALHL  (A1WVT9), 
HEM3_HALSA  (Q9HMY5), HEM3_HAMD5  (C4K4E3), HEM3_HELAH  (Q17W61), 
HEM3_HELHP  (Q7VFE9), HEM3_HELP2  (B6JKG8), HEM3_HELPG  (B5ZA04), 
HEM3_HELPH  (Q1CUR5), HEM3_HELPJ  (Q9ZMJ7), HEM3_HELPS  (B2US69), 
HEM3_HELPY  (P56140), HEM3_HISS1  (Q0I178), HEM3_HISS2  (B0UWZ8), 
HEM3_HUMAN  (P08397), HEM3_HYDCU  (Q31JG5), HEM3_HYPBU  (A2BL26), 
HEM3_HYPNA  (Q0BX92), HEM3_IDILO  (Q5QUS3), HEM3_IGNH4  (A8AAB4), 
HEM3_KLEP3  (B5XYL1), HEM3_KLEP7  (A6TGI8), HEM3_KLULA  (Q6CT60), 
HEM3_KORVE  (Q1INI6), HEM3_LARHH  (C1D679), HEM3_LAWIP  (Q1MPL2), 
HEM3_LEGPA  (Q5X1F2), HEM3_LEGPH  (Q5ZRY6), HEM3_LEGPL  (Q5WT65), 
HEM3_LEIXX  (Q6AHF1), HEM3_LISIN  (Q92BF8), HEM3_LISMC  (C1KVK3), 
HEM3_LISMF  (Q71ZB2), HEM3_LISMH  (B8DHJ2), HEM3_LISMO  (Q8Y6X5), 
HEM3_LISW6  (A0AJ05), HEM3_LYSSC  (B1HVD6), HEM3_MACCJ  (B9E743), 
HEM3_MANSM  (Q65VX7), HEM3_MARN8  (A1TXW9), HEM3_MARSD  (C6BYB7), 
HEM3_METAC  (Q8TT56), HEM3_METAR  (Q0W5T2), HEM3_METBF  (Q46CH0), 
HEM3_METBU  (Q12WM8), HEM3_METCA  (Q602K3), HEM3_METFK  (Q1GXA1), 
HEM3_METJA  (Q57989), HEM3_METMA  (Q8PW57), HEM3_METS5  (A4YD92), 
HEM3_METTH  (O26960), HEM3_MICLC  (C5CB88), HEM3_MOUSE  (P22907), 
HEM3_MYCA1  (A0QLI0), HEM3_MYCA9  (B1MHI5), HEM3_MYCBO  (P64337), 
HEM3_MYCBP  (A1KFY6), HEM3_MYCBT  (C1AKJ0), HEM3_MYCGI  (A4T340), 
HEM3_MYCLE  (Q49808), HEM3_MYCMM  (B2HRJ2), HEM3_MYCPA  (Q73SS0), 
HEM3_MYCTA  (A5TZP0), HEM3_MYCTO  (P9WMP2), HEM3_MYCTU  (P9WMP3), 
HEM3_MYCUA  (A0PW29), HEM3_MYCVP  (A1T3D3), HEM3_MYXXD  (Q1D8Z8), 
HEM3_NATTJ  (B2A1G7), HEM3_NEIMA  (Q9JVS4), HEM3_NEIMB  (Q9K0P6), 
HEM3_NEUCR  (Q6MW51), HEM3_NITEU  (Q82WS2), HEM3_NITHX  (Q1QQP5), 
HEM3_NITSB  (A6Q3S1), HEM3_NITWN  (Q3SVF3), HEM3_NOCFA  (Q5YP70), 
HEM3_NOSS1  (Q8YVU6), HEM3_OCEIH  (Q8CXC0), HEM3_OLEA2  (Q30Y29), 
HEM3_ORYSJ  (Q6H6D2), HEM3_PAEMA  (O69110), HEM3_PARDP  (A1B853), 
HEM3_PARMW  (Q7U5C2), HEM3_PARP8  (B2JEN9), HEM3_PARPJ  (B2T1D1), 
HEM3_PASMU  (Q9CK24), HEM3_PEA(Q43082), HEM3_PECAS  (Q6CZG3), 
HEM3_PECCP  (C6DHC2), HEM3_PELPB  (B4SFI2), HEM3_PELPD  (A1AUE7), 
HEM3_PELTS  (A5D3L5), HEM3_PHEZH  (B4RC21), HEM3_PHOLL  (Q7MYN1), 
HEM3_PROA2  (B4S922), HEM3_PROM0  (A3PBM0), HEM3_PROM1  (A2C0V4), 
HEM3_PROM2  (A8G3L1), HEM3_PROM3  (A2C7L8), HEM3_PROM4  (A9BEB6), 
HEM3_PROM5  (A2BVF7), HEM3_PROM9  (Q31C38), HEM3_PROMA  (Q7VD89), 
HEM3_PROMH  (B4F1X3), HEM3_PROMI  (Q59684), HEM3_PROMM  (Q7V697), 
HEM3_PROMP  (Q7V2I1), HEM3_PROMS  (A2BPX7), HEM3_PROMT  (Q46GS7), 
HEM3_PSEA6  (Q15Z15), HEM3_PSEA7  (A6VE37), HEM3_PSEA8  (B7V5F0), 
HEM3_PSEAB  (Q02EA3), HEM3_PSEAE  (Q60169), HEM3_PSEE4  (Q1I316), 
HEM3_PSEF5  (Q4K3X3), HEM3_PSEFS  (C3K424), HEM3_PSEP1  (A5VWX3), 
HEM3_PSEPF  (Q3K4T0), HEM3_PSEPG  (B0KH05), HEM3_PSEPK  (Q88RE5), 
HEM3_PSEPW  (B1J1V2), HEM3_PSESM  (Q88B91), HEM3_PSEU2  (Q500N6), 
HEM3_PSYIN  (A1T0R0), HEM3_PYRAE  (Q8ZYW7), HEM3_PYRAR  (A4WN24), 
HEM3_PYRCJ  (A3MWV7), HEM3_PYRIL  (A1RQK2), HEM3_PYRNV  (B1YDP0), 
HEM3_RALN1  (Q8XWW3), HEM3_RAT(P19356), HEM3_RHILO  (Q98EI7), 
HEM3_RHIME  (Q92LH7), HEM3_RHOBA  (Q7UPN0), HEM3_RICAE  (C3PNS9), 
HEM3_RICAH  (A8GNR5), HEM3_RICB8  (A8GXC8), HEM3_RICBR  (Q1RJN7), 
HEM3_RICCK  (A8EYJ9), HEM3_RICCN  (Q92HR5), HEM3_RICFE  (Q4ULA5), 
HEM3_RICM5  (A8F1Y8), HEM3_RICPR  (Q9ZD77), HEM3_RICPU  (C4K265), 
HEM3_RICRO  (B0BY00), HEM3_RICRS  (A8GSI6), HEM3_RICTY  (Q68WR3), 
HEM3_ROSCS  (A7NKU8), HEM3_ROSS1  (A5UU37), HEM3_RUBXD  (Q1AUK3), 
HEM3_RUMCH  (B8I0Q8), HEM3_RUMJO  (Q59293), HEM3_RUTMC  (A1AX51), 
HEM3_SACS2  (Q980U4), HEM3_SALAR  (A9MJ10), HEM3_SALDC  (B5FN93), 
HEM3_SALPA  (Q5PKL7), HEM3_SALPC  (C0Q3B3), HEM3_SALPK  (B5BIU8), 
HEM3_SALSV  (B4TNV3), HEM3_SALTI  (P0A1Q9), HEM3_SALTY  (P0A1Q8), 
HEM3_SCHPO  (Q09899), HEM3_SERP5  (A8G848), HEM3_SHEB2  (B8E879), 
HEM3_SHEB5  (A3D9Q4), HEM3_SHEB8  (A6WTG0), HEM3_SHEB9  (A9L5G0), 
HEM3_SHEFN  (Q088L3), HEM3_SHEHH  (B0TJ54), HEM3_SHEON  (Q8E9H0), 
HEM3_SHEPA  (A8GZG4), HEM3_SHEPC  (A4YBG2), HEM3_SHESA  (A0KS60), 
HEM3_SHESH  (A8G0W4), HEM3_SHESM  (Q0HN99), HEM3_SHESR  (Q0HQI7), 
HEM3_SHESW  (A1RPD7), HEM3_SHEWM  (B1KQC6), HEM3_SHIFL  (Q83PH4), 
HEM3_SHOC1  (Q5WEP5), HEM3_SORC5  (A9FDP9), HEM3_SPHAL  (Q1GP41), 
HEM3_STAA1  (A7X391), HEM3_STAA2  (A6U2D8), HEM3_STAA3  (Q2FG66), 
HEM3_STAA8  (O34090), HEM3_STAA9  (A5ITJ5), HEM3_STAAB  (Q2YTB9), 
HEM3_STAAC  (Q5HFA2), HEM3_STAAE  (A6QHK4), HEM3_STAAM  (P64340), 
HEM3_STAAN  (P64341), HEM3_STAAR  (Q6GG35), HEM3_STAAS  (Q6G8Q5), 
HEM3_STAAT  (A8Z2J1), HEM3_STAAW  (Q8NW74), HEM3_STACT  (B9DNE1), 
HEM3_STAEQ  (Q5HNN3), HEM3_STAES  (Q8CNY8), HEM3_STAHJ  (Q4L709), 
HEM3_STAS1  (Q49YA2), HEM3_STRM5  (B4SJT8), HEM3_STRMK  (B2FI06), 
HEM3_SULDN  (Q30S90), HEM3_SULIA  (C3MZR8), HEM3_SULIK  (C4KIZ9), 
HEM3_SULIL  (C3MJ21), HEM3_SULIM  (C3MYD9), HEM3_SULIN  (C3NF70), 
HEM3_SULIY  (C3N841), HEM3_SULNB  (A6Q7Y4), HEM3_SULTO  (Q976H1), 
HEM3_SYNC1  (Q3A009), HEM3_SYNE7  (Q31PM2), HEM3_SYNFM  (A0LN73), 
HEM3_SYNR3  (A5GSE0), HEM3_SYNS3  (Q0I8I3), HEM3_SYNS9  (Q3AWQ4), 
HEM3_SYNSC  (Q3ALS9), HEM3_SYNWW  (Q0AZ43), HEM3_SYNY3  (P73660), 
HEM3_THEAC  (Q9HKM5), HEM3_THEFY  (Q47LA7), HEM3_THET2  (Q72H57), 
HEM3_THET8  (Q5SLE8), HEM3_THEVB  (Q8DIE4), HEM3_THEVO  (Q97B26), 
HEM3_THIDA  (Q3SFT5), HEM3_THISH  (B8GSU8), HEM3_TRIL1  (B3E2H7), 
HEM3_VESOH  (A5CW34), HEM3_VIBA3  (B7VMD9), HEM3_VIBC1  (A7MXU9), 
HEM3_VIBCH  (Q9KVM1), HEM3_VIBPA  (Q87KI9), HEM3_VIBVU  (Q8DD85), 
HEM3_VIBVY  (Q7MQC7), HEM3_WOLSU  (Q7M8L2), HEM3_WOLWR  (C0R2M3), 
HEM3_XANAC  (Q8PPR3), HEM3_XANC5  (Q3BXV3), HEM3_XANC8  (Q4UYZ4), 
HEM3_XANCB  (B0RNI9), HEM3_XANCP  (Q8P536), HEM3_XANOM  (Q2NYU4), 
HEM3_XANOP  (B2SMV3), HEM3_XANOR  (Q5GVL2), HEM3_XYLF2  (B2I5K8), 
HEM3_XYLFA  (Q9PCX7), HEM3_XYLFM  (B0U2W8), HEM3_XYLFT  (Q87CC9), 
HEM3_YARLI  (Q6C097), HEM3_YEAST  (P28789), HEM3_YERE8  (A1JI86), 
HEM3_YERP3  (A7FD67), HEM3_YERPA  (Q1CBN1), HEM3_YERPB  (B2K065), 
HEM3_YERPE  (P46355), HEM3_YERPG  (A9R8K0), HEM3_YERPN  (Q1CNI3), 
HEM3_YERPP  (A4TRA8), HEM3_YERPS  (Q66G00), HEM3_YERPY  (B1JPE6)
» more

UniProtKB/Swiss-Prot
False negative sequences		 31 sequences 

HEM3_ACET2  (A3DIF0), HEM3_ACIF2  (B7JBH8), HEM3_ACIF5  (B5ERN6), 

HEM3_ALBFT  (Q21XQ9), HEM3_BLOFL  (Q7VRM4), HEM3_BLOPB  (Q491Z6), 
HEM3_CALS8  (A4XK06), HEM3_CHLMU  (Q9PK95), HEM3_CHLPN  (Q9Z9C9), 
HEM3_CHLTR  (O84301), HEM3_CLOAB  (Q97MU4), HEM3_CLOB1  (A7FSG8), 
HEM3_CLOB6  (C3L2Z3), HEM3_CLOBH  (A5I0B2), HEM3_CLOBJ  (C1FVB9), 
HEM3_CLOBK  (B1IHD1), HEM3_CLOBL  (A7GBW3), HEM3_CLOBM  (B1KY15), 
HEM3_CYTH3  (Q11XT5), HEM3_DESOH  (A8ZWG5), HEM3_LACE2  (C4Z552), 
HEM3_LIMRD  (A5VM67), HEM3_LIMRJ  (B2G9H4), HEM3_METKA  (Q8TXC8), 
HEM3_MOOTA  (Q2RJ26), HEM3_NITMS  (A9A1A1), HEM3_ORITB  (A5CDH4), 
HEM3_ORITI  (B3CUP9), HEM3_PICTO  (Q6L2G8), HEM3_STRSV  (A3CL78), 
HEM3_SYNAS  (Q2LQU2)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

HEM3_DICCH  (P40129), HEM3_YERIN  (P30527)


				
	

	

		PDB
[Detailed view]		
		
			18 PDB
			


			1AH5; 1GTK; 1PDA; 1YPN; 2YPN; 3ECR; 3EQ1; 4HTG; 5H6O; 5M6R; 5M7F; 7AAJ; 
			
				7AAK; 7CCX; 7CCY; 7CCZ; 7CD0; 8PND
			
			

			» more