PROSITE entry PS00491

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS00491
Entry name [info]	PROLINE_PEPTIDASE
Accession [info]	PS00491
Entry type [info]	PATTERN
Date [info]	01-MAY-1991 CREATED; 01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00417

Name and characterization of the entry

Description [info]	Aminopeptidase P and proline dipeptidase signature.
Pattern [info]	[HA]-[GSYR]-[LIVMT]-[SG]-H-x-[LIV]-G-[LIVMNKS]-x-[IVEL]-[HNC]-[DEV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	239 in 239 different sequences
Number of true positive hits	239 in 239 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	47
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	83.57 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

239 sequences

AMPEP_HELPY (O25681), AMPP1_AJECG (C0NDZ7), AMPP1_AJECH (C6HSY3),

AMPP1_AJECN (A6R035), AMPP1_AJEDR (C5GXZ9), AMPP1_ARATH (F4JQH3), 
AMPP1_ARTGP (E4USI8), AMPP1_ARTOC (C5FHR9), AMPP1_ASPCL (A1CAQ1), 
AMPP1_ASPFC (B0Y3V7), AMPP1_ASPFN (B8NEI6), AMPP1_ASPFU (Q4WUD3), 
AMPP1_ASPNC (A2QGR5), AMPP1_ASPOR (Q2U7S5), AMPP1_ASPTN (Q0CDB3), 
AMPP1_BLAGS (C5K105), AMPP1_BOTFB (A6RK67), AMPP1_CHAGB (Q2H8T2), 
AMPP1_COCP7 (C5P7J2), AMPP1_COCPS (E9CTR7), AMPP1_COLGM (E3QCU0), 
AMPP1_EMENI (Q5AVF0), AMPP1_FUSV7 (C7Z9Z7), AMPP1_LEPMJ (E5ABQ8), 
AMPP1_LOTJA (A0A2Z5GDY5), AMPP1_METAQ (E9E9B2), AMPP1_METRA (E9EUE6), 
AMPP1_NEOFI (A1DF27), AMPP1_NEUCR (Q7RYL6), AMPP1_PARBA (C1H978), 
AMPP1_PARBD (C1GEY4), AMPP1_PARBP (C0SCV1), AMPP1_PENRW (B6HQC9), 
AMPP1_PHANO (Q0UFY4), AMPP1_PODAN (B2AWV6), AMPP1_PYRO7 (A4RF35), 
AMPP1_PYRTR (B2VUU7), AMPP1_PYRTT (E3S7K9), AMPP1_SCLS1 (A7E4T8), 
AMPP1_SORMK (D1ZKF3), AMPP1_STRCO (P0A3Z1), AMPP1_STRLI (P0A3Z2), 
AMPP1_TUBMM (D5GAC6), AMPP1_VERA1 (C9SR45), AMPP2_AJECG (C0NF18), 
AMPP2_AJECH (C6HNY5), AMPP2_AJECN (A6QYF6), AMPP2_AJEDR (C5GKT2), 
AMPP2_ARTBC (D4B0B2), AMPP2_ARTGP (E4V1Q7), AMPP2_ARTOC (C5FUV0), 
AMPP2_ASPCL (A1CNW6), AMPP2_ASPFC (B0XN37), AMPP2_ASPFN (B8MZI5), 
AMPP2_ASPFU (Q4WRV9), AMPP2_ASPNC (A2QAW7), AMPP2_ASPOR (Q2UQH9), 
AMPP2_ASPTN (Q0CZM6), AMPP2_BLAGS (C5K0R2), AMPP2_BOTFB (A6SL16), 
AMPP2_CHAGB (Q2HA12), AMPP2_COCP7 (C5PAH2), AMPP2_COCPS (E9CY14), 
AMPP2_COLGM (E3Q897), AMPP2_EMENI (Q5BF48), AMPP2_METAQ (E9E2J4), 
AMPP2_METRA (E9F9J8), AMPP2_NEOFI (A1D1S6), AMPP2_PARBA (C1H3X3), 
AMPP2_PARBD (C1GHS9), AMPP2_PARBP (C0SDW6), AMPP2_PENRW (B6HAN0), 
AMPP2_PHANO (Q0V147), AMPP2_PODAN (B2AW39), AMPP2_PYRTR (B2WKR4), 
AMPP2_PYRTT (E3RNJ5), AMPP2_SCLS1 (A7ENP9), AMPP2_STRCO (P0A3Z3), 
AMPP2_STRLI (P0A3Z4), AMPP2_TALMQ (B6QAW7), AMPP2_TALSN (B8M2W9), 
AMPP2_TRIVH (D4D6B8), AMPP2_UNCRE (C4JY72), AMPP3_SORMK (D1ZBF6), 
AMPP_ECOLI  (P15034), AMPP_HAEIN  (P44881), AMPP_MYCGE  (P47566), 
AMPP_MYCPN  (P75313), AMPP_PLAF7  (A0A144A2H0), FRA1_YEAST  (Q07825), 
ICP55_SCHPO (Q10439), ICP55_YEAST (P40051), PEPD_HUMAN  (P12955), 
PEPD_MOUSE  (Q11136), PEPD_PONAB  (Q5RFB3), PEPD_RAT(Q5I0D7), 
PEPE_MYCBO  (P65811), PEPE_MYCTO  (P9WHS6), PEPE_MYCTU  (P9WHS7), 
PEPQ1_IDILO (Q5QXH5), PEPQ2_IDILO (Q5QVP2), PEPQ_ACTP2  (A3MYG3), 
PEPQ_ACTP7  (B3GZT0), PEPQ_AERHH  (A0KEL3), PEPQ_AERS4  (A4STF0), 
PEPQ_ALTSX  (Q44238), PEPQ_CITK8  (A8ACZ6), PEPQ_COLP3  (Q48AT5), 
PEPQ_CROS8  (A7MQN9), PEPQ_ECO24  (A7ZU52), PEPQ_ECO27  (B7UNH5), 
PEPQ_ECO45  (B7MHD2), PEPQ_ECO55  (B7L9A5), PEPQ_ECO57  (Q8X8I1), 
PEPQ_ECO5E  (B5YY94), PEPQ_ECO7I  (B7NV19), PEPQ_ECO81  (B7N2F3), 
PEPQ_ECO8A  (B7M650), PEPQ_ECOBW  (C5A021), PEPQ_ECODH  (B1XAK9), 
PEPQ_ECOHS  (A8A6V2), PEPQ_ECOK1  (A1AI34), PEPQ_ECOL5  (Q0TAK9), 
PEPQ_ECOL6  (Q8FBI1), PEPQ_ECOLC  (B1IW60), PEPQ_ECOLI  (P21165), 
PEPQ_ECOLU  (B7NFE8), PEPQ_ECOSE  (B6I4I7), PEPQ_ECOSM  (B1LM33), 
PEPQ_ECOUT  (Q1R465), PEPQ_EDWI9  (C5BCB6), PEPQ_ENT38  (A4WFX3), 
PEPQ_ERWT9  (B2VFE3), PEPQ_ESCF3  (B7LTY8), PEPQ_GLAP5  (B8F8H3), 
PEPQ_HAHCH  (Q2S6U2), PEPQ_KLEP3  (B5XYG9), PEPQ_KLEP7  (A6TGM5), 
PEPQ_LACDE  (Q9S6S1), PEPQ_LACDL  (P46545), PEPQ_LACHE  (O84913), 
PEPQ_MARN8  (A1TXT7), PEPQ_PECAS  (Q6DAP4), PEPQ_PECCP  (C6DI64), 
PEPQ_PHOLL  (Q7MZ93), PEPQ_PROMH  (B4EWE3), PEPQ_PSEA6  (Q15ZF7), 
PEPQ_PSET1  (Q3IJ21), PEPQ_PYRFU  (P81535), PEPQ_PYRHO  (O58885), 
PEPQ_SALA4  (B5EZW1), PEPQ_SALAR  (A9MIX1), PEPQ_SALCH  (Q57HM5), 
PEPQ_SALDC  (B5FNX9), PEPQ_SALEP  (B5QW86), PEPQ_SALG2  (B5RFL5), 
PEPQ_SALHS  (B4TBS6), PEPQ_SALNS  (B4SZ86), PEPQ_SALPA  (Q5PKQ1), 
PEPQ_SALPB  (A9MYB1), PEPQ_SALPC  (C0Q3F4), PEPQ_SALPK  (B5BIZ1), 
PEPQ_SALSV  (B4TNZ2), PEPQ_SALTI  (Q9L6L4), PEPQ_SALTY  (Q7CPD4), 
PEPQ_SERP5  (A8G8D3), PEPQ_SHEAM  (A1S1I9), PEPQ_SHEB2  (B8E3R4), 
PEPQ_SHEB5  (A3CYJ5), PEPQ_SHEB8  (A6WHA1), PEPQ_SHEB9  (A9KU92), 
PEPQ_SHEDO  (Q12TB3), PEPQ_SHEFN  (Q08A38), PEPQ_SHEHH  (B0TLC0), 
PEPQ_SHELP  (A3Q8U5), PEPQ_SHEON  (Q8EKR8), PEPQ_SHEPA  (A8GYG1), 
PEPQ_SHEPC  (A4Y1B7), PEPQ_SHEPW  (B8CHA2), PEPQ_SHESA  (A0KR51), 
PEPQ_SHESH  (A8FP64), PEPQ_SHESM  (Q0HPB6), PEPQ_SHESR  (Q0I0T2), 
PEPQ_SHESW  (A1RDW7), PEPQ_SHEWM  (B1KCZ4), PEPQ_SHIB3  (B2TVJ6), 
PEPQ_SHIBS  (Q31UE2), PEPQ_SHIDS  (Q32A22), PEPQ_SHIF8  (Q0SZ37), 
PEPQ_SHIFL  (Q83PG0), PEPQ_SHISS  (Q3YVC0), PEPQ_SODGM  (Q2NWT2), 
PEPQ_STRM5  (B4SI11), PEPQ_STRMK  (B2FT23), PEPQ_XANAC  (Q8PH57), 
PEPQ_XANC8  (Q4UY33), PEPQ_XANCB  (B0RP90), PEPQ_XANCP  (Q8P5S9), 
PEPQ_XANE5  (Q3BPR2), PEPQ_XANOM  (Q2P6N8), PEPQ_XANOR  (Q5H3T0), 
PEPQ_YERE8  (A1JIG5), PEPQ_YERP3  (A7FDF3), PEPQ_YERPA  (Q1C2C5), 
PEPQ_YERPB  (B2K0Z7), PEPQ_YERPE  (Q0WAP4), PEPQ_YERPG  (A9R755), 
PEPQ_YERPN  (Q1CN98), PEPQ_YERPP  (A4TR26), PEPQ_YERPS  (Q66FR7), 
PEPQ_YERPY  (B1JP62), XPP1_BOVIN  (Q1JPJ2), XPP1_DICDI  (Q54G06), 
XPP1_HUMAN  (Q9NQW7), XPP1_MOUSE  (Q6P1B1), XPP1_RAT(O54975), 
XPP2_HUMAN  (O43895), XPP2_MOUSE  (B1AVD1), XPP2_PIG(Q95333), 
XPP2_RAT(Q99MA2), Y1059_STAS1 (Q49YD7), Y1217_STAHJ (Q4L749), 
Y1271_STAEQ (Q5HNJ7), Y1383_STAES (Q8CNW9), Y1530_STAAN (Q7A552), 
Y1567_STAAB (Q2YTD2), Y1635_STAAS (Q6G8L9), Y1651_STAAW (Q8NW55), 
Y1654_STAA3 (Q2FG30), Y1708_STAAM (Q99TF5), Y1756_STAAC (Q5HF67), 
Y1786_STAAR (Q6GFZ9), Y1816_STAA8 (Q2FXL9), Y806_METJA  (Q58216), 
YAA1_SCHPO  (Q09795), YFH6_YEAST  (P43590), YKVY_BACSU  (O31689), 
YOD1_SCHPO  (Q9UUD8), YQHT_BACSU  (P54518)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

47 sequences

AMPP1_ARTBC (D4ARJ9), AMPP1_COPC7 (A8P5H7), AMPP1_LACBS (B0DZL3),

AMPP1_TALMQ (B6QG01), AMPP1_TALSN (B8M9W2), AMPP1_TRIVH (D4D891), 
AMPP2_FUSV7 (C7Z837), AMPP2_NEUCR (A7UWH7), AMPP2_PYRO7 (A4RQ11), 
AMPP2_SORMK (D1ZQL9), AMPP2_TUBMM (D5GHP2), AMPP2_VERA1 (C9SDK8), 
AMPP3_AJECG (C0NIF0), AMPP3_AJECH (C6H7R7), AMPP3_AJEDR (C5G874), 
AMPP3_ASPCL (A1CSI0), AMPP3_ASPFC (B0XW47), AMPP3_ASPFN (B8NC10), 
AMPP3_ASPFU (Q4X267), AMPP3_ASPNC (A2QKF6), AMPP3_ASPTN (Q0CFZ0), 
AMPP3_BLAGS (C5JQ04), AMPP3_BOTFB (A6SDE9), AMPP3_COCP7 (C5PHM7), 
AMPP3_COCPS (E9DDK8), AMPP3_EMENI (Q96WX8), AMPP3_FUSV7 (C7YVN8), 
AMPP3_LEPMJ (E4ZHV7), AMPP3_METAQ (E9DV56), AMPP3_METRA (E9EK74), 
AMPP3_NEOFI (A1DG66), AMPP3_PARBA (C1H9Q9), AMPP3_PARBD (C1GD57), 
AMPP3_PARBP (C0SHQ0), AMPP3_PENRW (B6H2M0), AMPP3_PHANO (Q0U6G5), 
AMPP3_PODAN (B2AFW1), AMPP3_PYRO7 (A4RAE9), AMPP3_PYRTR (B2WMQ2), 
AMPP3_PYRTT (E3S6N7), AMPP3_SCLS1 (A7EUB3), AMPP3_TALMQ (B6Q8T5), 
AMPP3_TALSN (B8M0Z4), AMPP3_UNCRE (C4JF09), AMPP3_VERA1 (C9SEV5), 
PEPD_DICDI  (Q55E60), PEPQ_PSEHA  (P77814)

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PDB
[Detailed view]

58 PDB

1A16; 1JAW; 1M35; 1N51; 1PV9; 1W2M; 1W7V; 1WBQ; 1WL6; 1WL9; 1WLR; 1WY2;
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