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PROSITE entry PS00383


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00383
Entry name [info] TYR_PHOSPHATASE_1
Accession [info] PS00383
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-AUG-2007 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00323
Associated ProRule [info] PRU10044

Name and characterization of the entry

Description [info] Tyrosine specific protein phosphatases active site.
Pattern [info] 
[LIVMF]-H-C-x(2)-G-x(2)-R-[STC]-[STAGP].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 387 in 357 different sequences
Number of true positive hits 374 in 344 different sequences
Number of 'unknown' hits 0
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 92
Number of 'partial' sequences 27
Precision (true positives / (true positives + false positives)) 96.64 %
Recall (true positives / (true positives + false negatives)) 80.26 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] active_site at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 344 sequences 

123R_IIV6   (O55737), CC14A_DANRE (A0A0R4IVA4), CC14A_HUMAN (Q9UNH5),
» more

UniProtKB/Swiss-Prot
False negative sequences		 92 sequences 

CDKN3_HUMAN (Q16667), D1060_DICDI (Q1ZXG8), DS22B_DANRE (Q566R7),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 27 sequences 

PTP10_STYPL (P28202), PTP11_STYPL (P28203), PTP12_STYPL (P28204),
» more

UniProtKB/Swiss-Prot
False positive sequences		 13 sequences 

HMCN1_MOUSE (D3YXG0), MTMRE_HUMAN (Q8NCE2), MTMRE_MOUSE (Q8VEL2),
» more

PDB
[Detailed view]		 700 PDB

1A5Y; 1BZC; 1BZH; 1BZJ; 1C83; 1C84; 1C85; 1C86; 1C87; 1C88; 1ECV; 1G4U;
» more