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PROSITE entry PS00262


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PURL: https://purl.expasy.org/prosite/signature/PS00262

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General information about the entry

Entry name [info] INSULIN
Accession [info] PS00262
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00235

Name and characterization of the entry

Description [info] Insulin family signature.
Pattern [info] 
C-C-{P}-{P}-x-C-[STDNEKPI]-x(3)-[LIVMFS]-x(3)-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 266 in 266 different sequences
Number of true positive hits 258 in 258 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 12
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 96.99 %
Recall (true positives / (true positives + false negatives)) 95.56 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 2
Site [info] disulfide at position 6
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 258 sequences 

BXA1_BOMMO  (Q17192), BXA1_SAMCY  (P33718), BXA2_BOMMO  (P15411),
» more

UniProtKB/Swiss-Prot
False negative sequences		 12 sequences 

BXB11_BOMMO (Q17196), ILA1_CAEEL  (Q21507), ILA2_CAEEL  (Q21508),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

RELX_PHODA  (Q7M3C4)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			8 sequences
			


			
ADA18_MACFA (Q95194), ADAM5_RAT   (Q5BK84), F256_CTEON  (P85032), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			493 PDB
			


			1A7F; 1AI0; 1AIY; 1APH; 1B17; 1B18; 1B19; 1B2A; 1B2B; 1B2C; 1B2D; 1B2E; 
			
			

			» more