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PROSITE entry PS00194


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00194
Entry name [info] THIOREDOXIN_1
Accession [info] PS00194
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00172

Name and characterization of the entry

Description [info] Thioredoxin family active site.
Pattern [info] 
[LIVMF]-[LIVMSTA]-x-[LIVMFYC]-[FYWSTHE]-x(2)-[FYWGTN]-C-[GATPLVE]-
[PHYWSTA]-C-{I}-x-{A}-x(3)-[LIVMFYWT].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 524 in 438 different sequences
Number of true positive hits 508 in 422 different sequences
Number of 'unknown' hits 0
Number of false positive hits 16 in 16 different sequences
Number of false negative sequences 171
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 96.95 %
Recall (true positives / (true positives + false negatives)) 74.82 %

Comments [info]

Taxonomic range [info] Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 3
Site [info] disulfide at position 8
Site [info] disulfide at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 422 sequences 

BS2_TRYBB   (P12865), CCMG_PARDP  (P52236), CITRX_ORYSI (A2YUQ6),
» more

UniProtKB/Swiss-Prot
False negative sequences		 171 sequences 

AHPC_MYCTO  (P9WQB6), AHPC_MYCTU  (P9WQB7), APR1_ARATH  (P92979),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

PDIA3_MESAU (P86235), PDIA3_PAPHA (P81246), THIO_CANLF  (P99505),
» more

UniProtKB/Swiss-Prot
False positive sequences		 16 sequences 

AT10B_MOUSE (B1AWN4), GLRX_RICCO  (P55143), GLRX_VERFO  (O81187),
» more

PDB
[Detailed view]		 462 PDB

1A23; 1A24; 1A2J; 1A2L; 1A2M; 1ACV; 1AIU; 1AUC; 1BED; 1BQ7; 1DBY; 1DSB;
» more