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PROSITE entry PS00189


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00189
Entry name [info] LIPOYL
Accession [info] PS00189
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00168

Name and characterization of the entry

Description [info] 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site.
Pattern [info] 
[GDN]-x(2)-[LIVF]-x(3)-{VH}-{M}-[LIVMFCA]-x(2)-[LIVMFA]-{LDFY}-{KPE}-x-K-
[GSTAIVW]-[STAIVQDN]-x(2)-[LIVMFS]-x(5)-[GCN]-x-[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 592 in 573 different sequences
Number of true positive hits 550 in 531 different sequences
Number of 'unknown' hits 0
Number of false positive hits 42 in 42 different sequences
Number of false negative sequences 50
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 92.91 %
Recall (true positives / (true positives + false negatives)) 91.67 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 3
Site [info] lipoyl at position 13
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 531 sequences 

ACOC_CUPNH  (P27747), ACOC_PSEPU  (Q59695), GCSH1_ARATH (P25855),
» more

UniProtKB/Swiss-Prot
False negative sequences		 50 sequences 

ACOC_BACSU  (O31550), BKDC_MYCTU  (O06159), GCSH1_AQUAE (O67151),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

ODO2_DELAC  (P83708), ODO2_MESAU  (P86219), ODO2_PSEPU  (P31051),
» more

UniProtKB/Swiss-Prot
False positive sequences		 42 sequences 

ADEC_LIGS1  (Q1WTM3), AGR9_CYCAE  (A0A5Q0QMX0), AGRV1_HUMAN (Q8WXG9),
» more

PDB
[Detailed view]		 59 PDB

1DXM; 1FYC; 1GHJ; 1GHK; 1HPC; 1HTP; 1IYU; 1IYV; 1K8M; 1K8O; 1LAB; 1LAC;
» more