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PROSITE entry PS00187


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00187
Entry name [info] TPP_ENZYMES
Accession [info] PS00187
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1995 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00166

Name and characterization of the entry

Description [info] Thiamine pyrophosphate enzymes signature.
Pattern [info] 
[LIVMF]-[GSA]-x(5)-P-x(4)-[LIVMFYW]-x-[LIVMF]-x-G-D-[GSA]-[GSAC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 116 in 116 different sequences
Number of true positive hits 109 in 109 different sequences
Number of 'unknown' hits 0
Number of false positive hits 7 in 7 different sequences
Number of false negative sequences 83
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 93.97 %
Recall (true positives / (true positives + false negatives)) 56.77 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 109 sequences 

ARUI_PSEAE  (Q9HUI8), CEAS_STRCL  (Q9LCV9), CFOL_ASPCN  (A0A2I2F2I5),
» more

UniProtKB/Swiss-Prot
False negative sequences		 83 sequences 

COMDE_METAC (Q8TKU6), COME_METJA  (P58416), COME_METTH  (O27275),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

ILVB_ARTPT  (P27868), PDC1_TOBAC  (P51845), PDC2_MAIZE  (Q05326),
» more

UniProtKB/Swiss-Prot
False positive sequences		 7 sequences 

COLB_DICDI  (Q8T2A1), DXS1_CERS4  (Q3J1A8), DXS1_ROSDO  (Q16DV7),
» more

PDB
[Detailed view]		 131 PDB

1BFD; 1JSC; 1MCZ; 1N0H; 1OVM; 1OZF; 1OZG; 1OZH; 1PI3; 1PO7; 1POW; 1POX;
» more