PROSITE entry PS00176
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PURL: https://purl.expasy.org/prosite/signature/PS00176
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General information about the entry
| Entry name [info] | TOPO_IB_1 |
| Accession [info] | PS00176 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00159 |
| Associated ProRule [info] | PRU10130 |
Name and characterization of the entry
| Description [info] | Topoisomerase (Topo) IB-type active site signature. |
| Pattern [info] |
[DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM]. |
Numerical results [info]
| Total number of hits | 27 in 27 different sequences |
| Number of true positive hits | 25 in 25 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 2 in 2 different sequences |
| Number of false negative sequences | 3 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 92.59 % |
| Recall (true positives / (true positives + false negatives)) | 89.29 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 8 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
25 sequences
TOP1A_ARATH (P30181), TOP1B_ARATH (Q9FJ79), TOP1M_HUMAN (Q969P6),» more
|
| UniProtKB/Swiss-Prot False negative sequences |
3 sequences
TOP1E_MIMIV (Q7T6X9), TOP1M_MOUSE (Q8R4U6), TOP1M_RAT (Q6IM78) |
| UniProtKB/Swiss-Prot False positive sequences |
2 sequences
L_DUGBA (Q66431), YE88_SCHPO (O14304) |
| PDB [Detailed view] |
14 PDB
1A31; 1A41; 1K4S; 1K4T; 1NH3; 1RR8; 1RRJ; 1SC7; 1SEU; 1T8I; 1TL8; 2H7F; » more |