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PROSITE entry PS00165


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00165
Entry name [info] DEHYDRATASE_SER_THR
Accession [info] PS00165
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00149

Name and characterization of the entry

Description [info] Serine/threonine dehydratases pyridoxal-phosphate attachment site.
Pattern [info] 
[DESH]-x(4,5)-[STVG]-{EVKD}-[AS]-[FYI]-K-[DLIFSA]-[RLVMF]-[GA]-[LIVMGA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 226 in 226 different sequences
Number of true positive hits 193 in 193 different sequences
Number of 'unknown' hits 0
Number of false positive hits 33 in 33 different sequences
Number of false negative sequences 19
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 85.40 %
Recall (true positives / (true positives + false negatives)) 91.04 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] pyridoxal_phosphate at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 193 sequences 

AKS11_ALTAL (V5Y0V0), ILVA_BACSU  (P37946), ILVA_BURM1  (P53607), 

ILVA_CORGL  (Q04513), ILVA_ECOLI  (P04968), ILVA_HAEIN  (P46493), 
ILVA_HALH5  (Q9KC63), ILVA_LACLA  (Q02145), ILVA_MYCBO  (P66898), 
ILVA_MYCLE  (Q9X7F1), ILVA_MYCTO  (P9WG94), ILVA_MYCTU  (P9WG95), 
ILVA_PASMU  (Q9CKJ2), ILVA_SALTY  (P20506), ILVA_STAA3  (Q2FF63), 
ILVA_STAA8  (Q2FWJ9), ILVA_STAAB  (Q2YUE8), ILVA_STAAC  (Q5HEE0), 
ILVA_STAAM  (Q99SJ1), ILVA_STAAN  (Q7A4H2), ILVA_STAAR  (Q3V7T5), 
ILVA_STAAS  (Q3V7T4), ILVA_STAAW  (Q8NVI8), ILVA_STAEQ  (Q5HMF5), 
ILVA_STAES  (Q8CNK9), ILVA_STAHJ  (Q4L7U4), ILVA_STAS1  (Q49Z16), 
LTHAD_PSESP (A4F2N8), LTHAD_YEAST (P36007), SDH1_YEASX  (P0CF23), 
SDHD1_ECOL5 (Q0TF95), SDHD1_ECOUT (Q1R901), SDHD2_ECOL5 (Q0T953), 
SDHD2_ECOUT (Q1R2Q6), SDHD_ACIAD  (Q6FDC1), SDHD_ACIB5  (B7I8P7), 
SDHD_ACIBC  (B2HVC6), SDHD_ACIBT  (A3M3B1), SDHD_AERHH  (A0KI76), 
SDHD_AERS4  (A4SPX2), SDHD_BACAC  (C3L7G5), SDHD_BACAH  (A0RCF8), 
SDHD_BACAN  (Q81S85), SDHD_BACC1  (Q73AC5), SDHD_BACC2  (B7IR88), 
SDHD_BACC3  (C1EPF1), SDHD_BACC4  (B7HID8), SDHD_BACC7  (B7HMG6), 
SDHD_BACCR  (Q81F73), SDHD_BACCZ  (Q63D23), SDHD_BACHK  (Q6HKG3), 
SDHD_BACMK  (A9VPH9), SDHD_BACSU  (P54555), SDHD_CHRVO  (Q7NUP9), 
SDHD_CITK8  (A8ACI7), SDHD_COLP3  (Q47V69), SDHD_DESHY  (Q24WR0), 
SDHD_ECO24  (A7ZPH2), SDHD_ECO45  (B7MH26), SDHD_ECO55  (B7LBR9), 
SDHD_ECO57  (Q8XCK5), SDHD_ECO5E  (B5YYW7), SDHD_ECO81  (B7MY25), 
SDHD_ECO8A  (B7M6N5), SDHD_ECOBW  (C4ZVQ3), SDHD_ECODH  (B1X9N9), 
SDHD_ECOHS  (A8A2M0), SDHD_ECOK1  (A1ADP3), SDHD_ECOL6  (Q8FFF4), 
SDHD_ECOLC  (B1IX96), SDHD_ECOLI  (P00926), SDHD_ECOLU  (B7N5W6), 
SDHD_ECOSE  (B6I6R7), SDHD_ECTM1  (A4XXF3), SDHD_ESCF3  (B7LK20), 
SDHD_GEOKA  (Q75TC9), SDHD_GEOSE  (Q75TH5), SDHD_HALH5  (Q9KC12), 
SDHD_HISS1  (Q0I5V1), SDHD_HISS2  (B0UWV3), SDHD_LACPL  (Q88TY1), 
SDHD_LIMF3  (B2GBP8), SDHD_OENOB  (Q04G28), SDHD_PEDPA  (Q03DF6), 
SDHD_PHOLL  (Q7N5H9), SDHD_PHOPR  (Q6LHF5), SDHD_PSEA8  (B7V2Y0), 
SDHD_PSEAB  (Q02QJ1), SDHD_PSEAE  (Q9HYN9), SDHD_PSEP1  (A5W4Y8), 
SDHD_PSEP7  (A6V271), SDHD_PSEPG  (B0KGK3), SDHD_SALA4  (B5EY75), 
SDHD_SALAR  (A9MKH2), SDHD_SALCH  (Q57I32), SDHD_SALDC  (B5FMC1), 
SDHD_SALEP  (B5QU31), SDHD_SALG2  (B5RG23), SDHD_SALHS  (B4TA53), 
SDHD_SALNS  (B4SY68), SDHD_SALPA  (Q5PKR3), SDHD_SALPB  (A9MWI4), 
SDHD_SALPC  (C0Q241), SDHD_SALPK  (B5BII6), SDHD_SALSV  (B4TMW9), 
SDHD_SALTI  (Q8Z2L4), SDHD_SALTY  (Q8ZL08), SDHD_SERP5  (A8GES6), 
SDHD_SHIBS  (Q31YA5), SDHD_SHIDS  (Q32DH8), SDHD_SHIF8  (Q0T2D1), 
SDHD_SHIFL  (Q83MK8), SDHD_SHISS  (Q3YZG4), SDHD_SHOC1  (Q5WGL6), 
SDHD_STAS1  (Q4A041), SDHD_VIBC1  (A7MYG2), SDHD_VIBC3  (A5F0M6), 
SDHD_VIBCH  (Q9KL72), SDHD_VIBCM  (C3LWD9), SDHD_VIBPA  (Q87QA2), 
SDHD_YERE8  (A1JJW5), SDHL_BOVIN  (Q0VCW4), SDHL_DICDI  (Q86B06), 
SDHL_HUMAN  (P20132), SDHL_MOUSE  (Q8VBT2), SDHL_RAT(P09367), 
SDHL_YEAS1  (B3LU13), SDHL_YEAS6  (B5VKE8), SDHL_YEAS7  (A6ZVB1), 
SDHL_YEAS8  (C8ZAU6), SDSL_HUMAN  (Q96GA7), SRR_ARATH   (Q2PGG3), 
SRR_BOVIN   (A0JNI4), SRR_HUMAN   (Q9GZT4), SRR_MOUSE   (Q9QZX7), 
SRR_RAT (Q76EQ0), STDH_YEAST  (P25379), TD1_SOLLC   (A0FKE6), 
TD2_SOLLC   (P25306), TDCB_ECO57  (P0AGF8), TDCB_ECOL6  (P0AGF7), 
TDCB_ECOLI  (P0AGF6), TDCB_SALTY  (P11954), TDCB_SHIFL  (P0AGF9), 
TDCB_STAA3  (Q2FH01), TDCB_STAA8  (Q2FYJ3), TDCB_STAAB  (Q2YY67), 
TDCB_STAAC  (Q5HFY5), TDCB_STAAM  (Q99U50), TDCB_STAAN  (Q7A5L8), 
TDCB_STAAR  (Q6GGX0), TDCB_STAAS  (Q6G9C4), TDCB_STAAW  (Q8NWQ4), 
TD_NICAT(Q9AXU4), THD1_ARATH  (Q9ZSS6), THDH_BLAAD  (O42615), 
THDH_SCHPO  (O94634), THDH_YEAST  (P00927), THNS2_DANRE (Q2YDP8), 
THNS2_XENLA (Q5XH07), THRC1_ARATH (Q9S7B5), THRC2_ARATH (Q9SSP5), 
THRC_BACSL  (P09123), THRC_BACSU  (P04990), THRC_BUCAI  (P57289), 
THRC_BUCAP  (Q8K9V1), THRC_BUCBP  (Q89AR5), THRC_CORGL  (P23669), 
THRC_CRYNH  (J9VI85), THRC_ECOLI  (P00934), THRC_EREGS  (Q00063), 
THRC_HAEIN  (P44503), THRC_HALH5  (Q9K7E3), THRC_HELPJ  (Q9ZMX5), 
THRC_HELPY  (O24924), THRC_METAC  (Q8TQD4), THRC_METGL  (P37145), 
THRC_METJA  (Q58860), THRC_MYCBO  (P66903), THRC_MYCLE  (P45837), 
THRC_MYCS2  (A0R220), THRC_MYCTO  (P9WG58), THRC_MYCTU  (P9WG59), 
THRC_PSEAE  (P29363), THRC_SCHPO  (Q42598), THRC_SERMA  (P27735), 
THRC_SOLTU  (Q9MT28), THRC_SYNY3  (P74193), THRC_YEAST  (P16120), 
TSAL_GEOSL  (Q74FW6), TSAL_THEMA  (Q9WYJ1), Y4TJ_SINFN  (P55664), 
YI168_YEAST (P0CF21)
» more

UniProtKB/Swiss-Prot
False negative sequences		 19 sequences 

SDHD_ACIET  (B9MIR7), SDHD_ACISJ  (A1W838), SDHD_BURL3  (Q396Y3), 

SDHD_BURP0  (A3P975), SDHD_BURP1  (Q3JJ76), SDHD_BURP6  (A3NNQ0), 
SDHD_BURPS  (Q63IF8), SDHD_BURTA  (Q2T8Q2), SDHD_CARHZ  (Q3AFZ5), 
SDHD_CUPPJ  (Q46X58), SDHD_FUSNN  (Q8RFX6), SDHD_HAHCH  (Q2SHX7), 
SDHD_PARC0  (A1TPW5), SDHD_POLNA  (A1VWK8), SDHD_RHIE6  (B3PYT5), 
SDHD_RHILW  (B5ZNC1), SDHD_SINMW  (A6UB95), SRR_SCHPO   (O59791), 
THD1_CICAR  (Q39469)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

TD_SOLTU(P31212)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			33 sequences
			


			
ACTN3_BOVIN (Q0III9), ACTN3_HUMAN (Q08043), ACTN3_MOUSE (O88990), 

			
ACUF_ASPA1  (P9WF00), ALKD_PSEPU  (P00885), AROE_PYRAE  (Q8ZW89), 
BFPB_ECO11  (Q9S142), BFPB_ECO27  (Q47068), CY551_ALLVD (P80549), 
CY551_PSEAE (P00099), CYSM_CAMJE  (P71128), DHOM_HELPJ  (Q9ZL20), 
DHOM_HELPY  (P56429), DIP2A_MOUSE (Q8BWT5), DNLJ_BEII9  (B2IGH4), 
FEOB_LEPIC  (Q72SI0), FEOB_LEPIN  (Q8F332), GCST_PSESM  (Q88AS0), 
HNRLL_HUMAN (Q8WVV9), HNRLL_MOUSE (Q921F4), IQD18_ARATH (Q9MAM4), 
KAS1_STRVN  (P16540), LCSA_PURLI  (A0A179H164), PALLD_HUMAN (Q8WX93), 
PFMAE_PESFW (W3X7U2), PLSP2_LOTGI (B3A0P3), RL15_AGRFC  (Q8UE36), 
RLR12_PLAHL (A0A0P1AZU2), RS20_CUPMC  (Q1LJ99), RS20_CUPPJ  (Q46XK7), 
RSMG_CLOB8  (A6M3M3), SYLC_DICDI  (Q54N83), XRCC4_SCHPO (Q92361)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			36 PDB
			


			1E5X; 1KL7; 1P5J; 1PWE; 1PWH; 1TDJ; 1VB3; 2C2B; 2C2G; 2D1F; 2GN0; 2GN1; 
			
				2GN2; 2RKB; 3HMK; 3IAU; 3L6B; 3L6C; 3L6R; 3R0X; 3R0Z; 3SS7; 3SS9; 4H27; 
				5X2L; 6AA9; 6SLH; 6ZSP; 6ZUJ; 7NBC; 7NBD; 7NBF; 7NBG; 7NBH; 8ZKV; 8ZLV
			
			

			» more