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PROSITE entry PS00144


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PURL: https://purl.expasy.org/prosite/signature/PS00144

Direct ScanProsite submission
General information about the entry

Entry name [info] ASN_GLN_ASE_1
Accession [info] PS00144
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00132
Associated ProRule [info] PRU10099

Name and characterization of the entry

Description [info] Asparaginase / glutaminase active site signature 1.
Pattern [info] 
[LIVM]-x-{L}-T-G-G-T-[IV]-[AGS].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 129 in 129 different sequences
Number of true positive hits 53 in 53 different sequences
Number of 'unknown' hits 1
Number of false positive hits 75 in 75 different sequences
Number of false negative sequences 18
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 41.41 %
Recall (true positives / (true positives + false negatives)) 74.65 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 53 sequences 

ASP21_YEAST (P0CZ17), ASP22_YEAST (P0CX77), ASP23_YEAST (P0CX78), 

ASP24_YEAST (P0CX79), ASPG1_BACSU (P26900), ASPG1_ECO57 (P0A963), 
ASPG1_ECOLI (P0A962), ASPG1_YEAST (P38986), ASPG2_BACSU (O34482), 
ASPG2_ECOLI (P00805), ASPG2_HAEIN (P43843), ASPG_BACLI  (P30363), 
ASPG_DEIRA  (Q9RRX9), ASPG_DICCH  (P06608), ASPG_DIRIM  (Q9U518), 
ASPG_HELPJ  (Q9ZLB9), ASPG_HELPY  (O25424), ASPG_MYCBO  (P63628), 
ASPG_MYCLE  (Q9X7E6), ASPG_MYCTO  (P9WPX4), ASPG_MYCTU  (P9WPX5), 
ASPG_THEKO  (Q5JIW4), ASPG_WOLSU  (P50286), ASPQ_ACIGL  (P10172), 
ASPQ_DELAC  (P83712), ASPQ_PSEAE  (Q9I407), ASPQ_PSEFA  (O68897), 
ASPQ_PSEPK  (Q88K39), ASPQ_PSES7  (P10182), GATD_ARCFU  (O29380), 
GATD_HALS3  (B0R6H4), GATD_HALSA  (Q9HP20), GATD_HALWD  (Q18GL3), 
GATD_METAC  (Q8TR66), GATD_METBF  (Q46GJ6), GATD_METBU  (Q12X65), 
GATD_METJA  (Q60331), GATD_METKA  (Q8TV84), GATD_METM5  (A4FWR5), 
GATD_METM6  (A9AA46), GATD_METM7  (A6VGK5), GATD_METMA  (Q8PUM7), 
GATD_METMP  (P61400), GATD_METS3  (A5UK11), GATD_METST  (Q2NEH1), 
GATD_METTH  (O26802), GATD_METVS  (A6UPR4), GATD_PYRAB  (Q9V0T9), 
GATD_PYRFU  (Q8U0X0), GATD_PYRHO  (O59132), GATD_THEAC  (Q9HJJ5), 
GATD_THEKO  (Q5JI77), GATD_THEVO  (Q979L8)
» more

UniProtKB/Swiss-Prot
False negative sequences		 18 sequences 

ASPG_PYRFU  (Q8TZE8), GATD_AERPE  (Q9Y9T8), GATD_METS5  (A4YHH3), 

GATD_NANEQ  (P61401), GATD_PYRAE  (Q8ZY04), GATD_SACI1  (C3NHQ2), 
GATD_SACI2  (C3MPS1), GATD_SACI3  (C3N5E7), GATD_SACI4  (C3MYR5), 
GATD_SACI6  (C4KH13), GATD_SACI7  (C3NE01), GATD_SACS2  (Q97ZH5), 
GATD_SULAC  (Q4J955), GATD_SULTO  (Q971W5), GATD_THEPD  (A1RX40), 
LPP60_HUMAN (Q86U10), LPP60_MOUSE (A0JNU3), LPP60_RAT   (O88202)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

DESPA_DANRE (A0A8M2BID5)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			75 sequences
			


			
API10_SOLTU (Q03197), API11_SOLTU (P16348), API1_SOLTU  (Q41480), 

			
API2_SOLTU  (Q43646), API3_SOLTU  (P58518), API4_SOLTU  (Q43645), 
API5_SOLTU  (P58519), API6_SOLTU  (P58520), API7_SOLTU  (Q41448), 
API8_SOLTU  (P17979), API9_SOLTU  (P58521), APT_BLOPB   (Q493A5), 
APT_CHLAA   (A9WCV7), APT_CLOB1   (A7FY09), APT_CLOBH   (A5I6E1), 
APT_CLOBK   (B1IME3), APT_CLOBL   (A7GHS8), APT_CLOBM   (B1L0A2), 
APT_CLOP1   (Q0TP22), APT_CLOPE   (Q8XJ22), APT_CLOPS   (Q0SRP2), 
APT_DESRM   (A4J2G8), APT_LACLA   (Q9CHT5), APT_LACLM   (A2RIW0), 
APT_LACLS   (Q031A0), APT_LACP3   (Q038P1), APT_LACPL   (Q88VH0), 
APT_LATSS   (Q38W53), APT_LEVBA   (Q03QP8), APT_LIGS1   (Q1WT53), 
APT_METM7   (A6VJW6), APT_MYCBO   (P59959), APT_MYCBP   (A1KLT2), 
APT_MYCSJ   (A3PYX7), APT_MYCSK   (A1UFB6), APT_MYCSS   (Q1B9P7), 
APT_MYCTA   (A5U5T4), APT_MYCTO   (P9WQ06), APT_MYCTU   (P9WQ07), 
APT_PEDPA   (Q03F39), APT_PROM5   (A2BXB1), APT_ROSCS   (A7NG77), 
APT_ROSS1   (A5URA4), APT_SYNC1   (Q3A4N0), APT_UREP2   (B1AJC8), 
APT_UREPA   (Q9PQ02), ATM1_CHAGB  (Q2HIE9), ATRN1_MOUSE (Q6A051), 
CDIA2_BURP2 (I1WVY3), DSCA1_DROME (Q0E9H9), KPRS2_ARCFU (O28853), 
KPRS_AERPE  (Q9YAW0), KPRS_COREF  (Q8FQV2), KPRS_CORGL  (Q8NRU9), 
KPRS_MYCBO  (P65233), KPRS_MYCLE  (Q9CD45), KPRS_MYCTO  (P9WKE2), 
KPRS_MYCTU  (P9WKE3), KPRS_NOSS1  (Q8YN97), KPRS_THEAC  (Q9HLV6), 
KPRS_THEVO  (Q97CA5), MACB_NITEU  (Q82VK1), PPR4_ARATH  (Q9FZ24), 
ROCO5_DICDI (Q1ZXD6), SPI1_SOLTU  (P58514), SPI2_SOLTU  (P58515), 
SPI4_SOLTU  (P58517), SPI5_SOLTU  (Q41484), SPI6_SOLTU  (Q41433), 
SPI7_SOLTU  (P30941), SPIKE_ADECT (Q65914), Y1519_RHILW (B5ZMI8), 
Y1668_ARATH (Q9C9N5), Y2074_RHIJ3 (Q1MHJ7), YCGA_BACSU  (P55908)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			86 PDB
			


			1AGX; 1DJO; 1DJP; 1HFJ; 1HFK; 1HFW; 1HG0; 1HG1; 1HO3; 1IHD; 1JAZ; 1JJA; 
			
				1JSL; 1JSR; 1NNS; 1O7J; 1WSA; 1ZQ1; 2D6F; 2HIM; 2P2D; 2P2N; 2WLT; 2WT4; 
				3ECA; 3PGA; 4PGA; 5F52; 5HW0; 5I3Z; 5I48; 5I4B; 5K3O; 5K45; 5K4G; 5K4H; 
				5MQ5; 5OT0; 6EOK; 6NX6; 6NX7; 6NX8; 6NX9; 6NXA; 6NXB; 6NXC; 6NXD; 6PA2; 
				6PA3; 6PA4; 6PA5; 6PA6; 6PA8; 6PAB; 6PAC; 6PAE; 6RUD; 6RUE; 6RUF; 6SYH; 
				6UOD; 6UOG; 6UOH; 6V23; 6V24; 6V25; 6V26; 6V29; 6V2A; 6V2B; 6V5F; 6WYW; 
				6WYX; 6WYY; 6WYZ; 6WZ4; 6WZ6; 6WZ8; 7M11; 7P9C; 7R57; 7R5Q; 7U6M; 8ECD; 
				8ECE; 8WGQ
			
			

			» more