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PROSITE entry PS00141


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PURL: https://purl.expasy.org/prosite/signature/PS00141

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General information about the entry

Entry name [info] ASP_PROTEASE
Accession [info] PS00141
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00128
Associated ProRule [info] PRU10094

Name and characterization of the entry

Description [info] Eukaryotic and viral aspartyl proteases active site.
Pattern [info] 
[LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-[STAPDENQ]-{GQ}-
[LIVMFSTNC]-{EGK}-[LIVMFGTA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 737 in 560 different sequences
Number of true positive hits 611 in 434 different sequences
Number of 'unknown' hits 1
Number of false positive hits 125 in 125 different sequences
Number of false negative sequences 70
Number of 'partial' sequences 45
Precision (true positives / (true positives + false positives)) 83.02 %
Recall (true positives / (true positives + false negatives)) 89.72 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 434 sequences 

AED1_ARATH  (Q9LEW3), APA1_ARATH  (O65390), APA2_ARATH  (Q8VYL3),
» more

UniProtKB/Swiss-Prot
False negative sequences		 70 sequences 

AED3_ARATH  (O04496), ASP2_BLAGE  (P54958), ASP36_ARATH (Q4V3D2),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 45 sequences 

CARDE_CYNCA (P85136), CHYM_FELCA  (P09873), NEP1_NEPDI  (P69476),
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

AWP3B_CANGA (B4UN32)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			125 sequences
			


			
5MOAS_ASPTN (Q0CRQ5), A30BL_HUMAN (A7E2S9), AARE_ARATH  (Q84LM4), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			2240 PDB
			


			1A30; 1A8G; 1A8K; 1A94; 1A9M; 1AAQ; 1AID; 1AJV; 1AJX; 1AM5; 1APT; 1APU; 
			
			

			» more