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PROSITE entry PS00139


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00139
Entry name [info] THIOL_PROTEASE_CYS
Accession [info] PS00139
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00126
Associated ProRule [info] PRU10088

Name and characterization of the entry

Description [info] Eukaryotic thiol (cysteine) proteases cysteine active site.
Pattern [info] 
Q-{V}-x-{DE}-[GE]-{F}-C-[YW]-{DN}-x-[STAGC]-[STAGCV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 299 in 299 different sequences
Number of true positive hits 282 in 282 different sequences
Number of 'unknown' hits 0
Number of false positive hits 17 in 17 different sequences
Number of false negative sequences 57
Number of 'partial' sequences 21
Precision (true positives / (true positives + false positives)) 94.31 %
Recall (true positives / (true positives + false negatives)) 83.19 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 282 sequences 

361L_IIV6   (Q91FG3), ACTN_ACTCC  (P00785), ACTN_ACTDE  (A5HII1),
» more

UniProtKB/Swiss-Prot
False negative sequences		 57 sequences 

CAN13_HUMAN (Q6MZZ7), CAN6_HUMAN  (Q9Y6Q1), CAN6_MOUSE  (O35646),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 21 sequences 

CAL1_CALGI  (P20728), CAN1_RABIT  (P06815), CAN2_PIG(P43367),
» more

UniProtKB/Swiss-Prot
False positive sequences		 17 sequences 

ACLI_ASPOR  (Q2UPB9), CB042_BOVIN (Q3SYX3), CB042_HUMAN (Q9NWW7),
» more

PDB
[Detailed view]		 344 PDB

1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO; 1BP4;
» more