PROSITE entry PS00110
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PURL: https://purl.expasy.org/prosite/signature/PS00110
Direct ScanProsite submission
General information about the entry
| Entry name [info] | PYRUVATE_KINASE |
| Accession [info] | PS00110 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-JUL-1999 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00101 |
Name and characterization of the entry
| Description [info] | Pyruvate kinase active site signature. |
| Pattern [info] |
[LIVAC]-x-[LIVM](2)-[SAPCV]-K-[LIV]-E-[NKRST]-x-[DEQHS]-[GSTA]-[LIVM]. |
Numerical results [info]
| Total number of hits | 84 in 84 different sequences |
| Number of true positive hits | 79 in 79 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 5 in 5 different sequences |
| Number of false negative sequences | 22 |
| Number of 'partial' sequences | 4 |
| Precision (true positives / (true positives + false positives)) | 94.05 % |
| Recall (true positives / (true positives + false negatives)) | 78.22 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 5 |
| Site [info] | magnesium at position 7 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
79 sequences
KPYA_RICCO (Q43117), KPYA_TOBAC (Q40545), KPYC_ARATH (O65595),» more
|
| UniProtKB/Swiss-Prot False negative sequences |
22 sequences
KPYK_AERPE (Q9YEU2), KPYK_CHLMU (Q9PK61), KPYK_CHLPN (Q9Z984),» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
4 sequences
KPYK1_PHOLE (O30853), KPYK_CLOPA (P81344), KPYK_LEIBR (Q04668),» more |
| UniProtKB/Swiss-Prot False positive sequences |
5 sequences
ABITM_DROME (Q9VFR1), AROB_BRUA2 (Q2YR43), AROB_BRUAB (Q57AM9),» more |
| PDB [Detailed view] |
164 PDB
1A3W; 1A3X; 1A49; 1A5U; 1AQF; 1E0T; 1E0U; 1F3W; 1F3X; 1PKL; 1PKM; 1PKN; » more |