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PROSITE entry PS00099


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00099
Entry name [info] THIOLASE_3
Accession [info] PS00099
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00092
Associated ProRule [info] PRU10020

Name and characterization of the entry

Description [info] Thiolases active site.
Pattern [info] 
[AG]-[LIVMA]-[STAGCLIVM]-[STAG]-[LIVMA]-C-{Q}-[AG]-x-[AG]-x-[AG]-x-[SAG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 301 in 301 different sequences
Number of true positive hits 260 in 260 different sequences
Number of 'unknown' hits 0
Number of false positive hits 41 in 41 different sequences
Number of false negative sequences 50
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 86.38 %
Recall (true positives / (true positives + false negatives)) 83.87 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 260 sequences 

AACT1_ARATH (Q9FIK7), ACCT2_ARATH (Q8S4Y1), ATOB_ECOLI  (P76461),
» more

UniProtKB/Swiss-Prot
False negative sequences		 50 sequences 

BBSB_GEOMG  (Q39VG1), BBSB_THAAR  (Q9KJF3), ER10B_ASPFC (B0YA65),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 3 sequences 

THIL_PIG(P14610), THLA_CLODI  (P45362), THLA_CLOPA  (P81347)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			41 sequences
			


			
ACON_BOVIN  (P20004), ACON_CAEEL  (P34455), ACON_HUMAN  (Q99798), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			107 PDB
			


			1AFW; 1DLU; 1DLV; 1DM3; 1M1O; 1M1T; 1M3K; 1M3Z; 1M4S; 1M4T; 1NL7; 1OU6; 
			
			

			» more