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PROSITE entry PS00091


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00091
Entry name [info] THYMIDYLATE_SYNTHASE
Accession [info] PS00091
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00086
Associated ProRule [info] PRU10016

Name and characterization of the entry

Description [info] Thymidylate synthase active site.
Pattern [info] 
R-x(2)-[LIVMT]-x(2,3)-[FWY]-[QNYDI]-x(8,13)-[LVESI]-x-P-C-[HAVMLC]-x(3)-
[QMTLHD]-[FYWL]-x(0,1)-[LV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 404 in 404 different sequences
Number of true positive hits 403 in 403 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 49
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.75 %
Recall (true positives / (true positives + false negatives)) 89.16 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 11
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 403 sequences 

DRTS1_ARATH (Q05762), DRTS2_ARATH (Q05763), DRTS_CRIFA  (Q23695),
» more

UniProtKB/Swiss-Prot
False negative sequences		 49 sequences 

DRTS_PLAVN  (P46103), TYSY_ACTSZ  (A6VMA0), TYSY_ALCBS  (Q0VM06),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

TYSY_STAEP  (P0C0M4)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
DCLK_CAEEL  (Q95QC4)


				
	

	

		PDB
[Detailed view]		
		
			247 PDB
			


			1AIQ; 1AJM; 1AN5; 1AOB; 1AXW; 1B02; 1BDU; 1BID; 1BJG; 1BKO; 1BKP; 1BO7; 
			
			

			» more