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PROSITE entry PS00086


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PURL: https://purl.expasy.org/prosite/signature/PS00086

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General information about the entry

Entry name [info] CYTOCHROME_P450
Accession [info] PS00086
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00081

Name and characterization of the entry

Description [info] Cytochrome P450 cysteine heme-iron ligand signature.
Pattern [info] 
[FW]-[SGNH]-x-[GD]-{F}-[RKHPT]-{P}-C-[LIVMFAP]-[GAD].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 1'596 in 1'594 different sequences
Number of true positive hits 1'546 in 1'546 different sequences
Number of 'unknown' hits 1
Number of false positive hits 49 in 47 different sequences
Number of false negative sequences 107
Number of 'partial' sequences 10
Precision (true positives / (true positives + false positives)) 96.93 %
Recall (true positives / (true positives + false negatives)) 93.53 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] heme_iron at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 1546 sequences 

10H_STRNX   (P0DO85), 11H_STRNX   (P0DO87), 72A61_PARPY (A0A517FNC4),
ยป more

UniProtKB/Swiss-Prot
False negative sequences		 107 sequences 

AACUE_ASPA1 (A0A1L9WLE2), AFLN_ASPPU  (Q6UEG2), AKNT_STRGJ  (Q9L4U5),
ยป more

UniProtKB/Swiss-Prot
'Partial' sequences		 10 sequences 

C71A3_SOLME (P37119), CP11A_RABIT (Q28827), CP1A2_CHICK (Q01741),
ยป more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

OLCB_PENCN  (P9WEQ1)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			47 sequences
			


			
AAPK1_CAEEL (P45894), ATS1_HUMAN  (Q9UHI8), BOC_HUMAN   (Q9BWV1), 

			
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		PDB
[Detailed view]		
		
			881 PDB
			


			1AKD; 1BU7; 1BVY; 1C8J; 1CL6; 1CMJ; 1CMN; 1CP4; 1CPT; 1DT6; 1DZ4; 1DZ6; 
			
			

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