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PROSITE entry PS00070


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00070
Entry name [info] ALDEHYDE_DEHYDR_CYS
Accession [info] PS00070
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00068
Associated ProRule [info] PRU10008

Name and characterization of the entry

Description [info] Aldehyde dehydrogenases cysteine active site.
Pattern [info] 
[FYLVA]-x-{GVEP}-{DILV}-G-[QE]-{LPYG}-C-[LIVMGSTANC]-[AGCN]-{HE}-
[GSTADNEKR].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 714 in 714 different sequences
Number of true positive hits 584 in 584 different sequences
Number of 'unknown' hits 1
Number of false positive hits 129 in 129 different sequences
Number of false negative sequences 119
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 81.91 %
Recall (true positives / (true positives + false negatives)) 83.07 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 584 sequences 

A9A1A_DANRE (Q7ZVB2), A9A1B_DANRE (Q802W2), AADH1_MALDO (A0A0E3T552),
» more

UniProtKB/Swiss-Prot
False negative sequences		 119 sequences 

A16A1_BOVIN (A6QR56), A16A1_HUMAN (Q8IZ83), A16A1_MOUSE (Q571I9),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 6 sequences 

AL7A1_ACASC (P83402), AL7A1_CTEID (P84463), ALDH2_GEOSE (P45959),
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

MMSA_MOUSE  (Q9EQ20)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			129 sequences
			


			
BY55_MOUSE  (O88875), CC194_HUMAN (A0A1B0GVG4), CCHL_CAEEL  (P53703), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			173 PDB
			


			1A4S; 1A4Z; 1AD3; 1AG8; 1BI9; 1BPW; 1BXS; 1CW3; 1EUH; 1NZX; 1NZZ; 1O00; 
			
			

			» more