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PROSITE entry PS00065


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00065
Entry name [info] D_2_HYDROXYACID_DH_1
Accession [info] PS00065
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00063

Name and characterization of the entry

Description [info] D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature.
Pattern [info] 
[LIVMA]-[AG]-[IVT]-[LIVMFY]-[AG]-x-G-[NHKRQGSAC]-[LIV]-G-x(13,14)-
[LIVMFT]-{A}-x-[FYWCTH]-[DNSTK].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 249 in 249 different sequences
Number of true positive hits 195 in 195 different sequences
Number of 'unknown' hits 0
Number of false positive hits 54 in 54 different sequences
Number of false negative sequences 215
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 78.31 %
Recall (true positives / (true positives + false negatives)) 47.56 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 195 sequences 

2KGR_VITVI  (A5CAL1), CTBP1_CAEEL (Q20595), CTBP1_HUMAN (Q13363),
» more

UniProtKB/Swiss-Prot
False negative sequences		 215 sequences 

2KGR_GLUOX  (Q5FTU6), CTBP2_BOVIN (Q0VCQ1), CTBP2_HUMAN (P56545),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

YMP5_STRCH  (P43169)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			54 sequences
			


			
ADH7_YEAST  (P25377), ADHA_SYNY3  (P74721), ADH_STAA3   (Q2FJ31), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			74 PDB
			


			1DXY; 1GDH; 1HKU; 1HL3; 1J49; 1J4A; 1MX3; 1PSD; 1SC6; 1YBA; 1YGY; 2DBQ; 
			
			

			» more