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PROSITE entry PS00064


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PURL: https://purl.expasy.org/prosite/signature/PS00064

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General information about the entry

Entry name [info] L_LDH
Accession [info] PS00064
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-MAY-1991 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00062
Associated ProRule [info] PRU10002

Name and characterization of the entry

Description [info] L-lactate dehydrogenase active site.
Pattern [info]
[LIVMA]-G-[EQ]-H-G-[DN]-[ST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 306 in 306 different sequences
Number of true positive hits 298 in 298 different sequences
Number of 'unknown' hits 0
Number of false positive hits 8 in 8 different sequences
Number of false negative sequences 13
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 97.39 %
Recall (true positives / (true positives + false negatives)) 95.82 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 4
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
298 sequences

DHL2_WEICO  (P14295), LDH1_BACAN  (Q81RW4), LDH1_BACC1  (P62047), 
» more

UniProtKB/Swiss-Prot
False negative sequences
13 sequences

IND2_STRGR  (A0A0D4BSN8), LDH2_CLOAB  (Q97DC6), LDH3_LACLA  (Q9CGG8), 
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

LDH_PLAFA   (P13774)

		
UniProtKB/Swiss-Prot
False positive sequences
8 sequences

IXTPA_CLOTE (Q891I4), MDH_ARCFU   (O08349), MDH_METJA   (Q60176), 
» more

PDB
[Detailed view]
123 PDB

1A5Z; 1EZ4; 1HYH; 1I0Z; 1I10; 1LDB; 1LDM; 1LDN; 1LLC; 1LLD; 1LTH; 1T2F;
» more