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PROSITE entry PS00063


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00063
Entry name [info] ALDOKETO_REDUCTASE_3
Accession [info] PS00063
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00061

Name and characterization of the entry

Description [info] Aldo/keto reductase family putative active site signature.
Pattern [info] 
[LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x-
{LVRI}-[LIVMFA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 193 in 193 different sequences
Number of true positive hits 130 in 130 different sequences
Number of 'unknown' hits 0
Number of false positive hits 63 in 63 different sequences
Number of false negative sequences 73
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 67.36 %
Recall (true positives / (true positives + false negatives)) 64.04 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site(?) at position 8
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 130 sequences 

6DCS_SOYBN  (P26690), A1A1A_DANRE (Q6AZW2), A1A1B_DANRE (Q568L5),
» more

UniProtKB/Swiss-Prot
False negative sequences		 73 sequences 

AK1BF_HUMAN (C9JRZ8), AK1CD_MESAU (P82809), AK1CD_MOUSE (Q8VC28),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

CROB_LEPLU  (P49261), DHGP_ASPNG  (P55804)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			63 sequences
			


			
AAP1_ARATH  (Q42400), AAP6_ARATH  (P92934), ATPFD_MYCA9 (B1MLV9), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			342 PDB
			


			1ABN; 1ADS; 1AE4; 1AFS; 1AH0; 1AH3; 1AH4; 1AZ1; 1AZ2; 1C9W; 1CWN; 1DLA; 
			
			

			» more