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PROSITE entry PS00061


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PURL: https://purl.expasy.org/prosite/signature/PS00061

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General information about the entry

Entry name [info] ADH_SHORT
Accession [info] PS00061
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00060
Associated ProRule [info] PRU10001

Name and characterization of the entry

Description [info] Short-chain dehydrogenases/reductases family signature.
Pattern [info] 
[LIVSPADNK]-x(9)-{P}-x(2)-Y-[PSTAGNCV]-[STAGNQCIVM]-[STAGC]-K-{PC}-
[SAGFYR]-[LIVMSTAGD]-x-{K}-[LIVMFYW]-{D}-x-{YR}-[LIVMFYWGAPTHQ]-
[GSACQRHM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 903 in 901 different sequences
Number of true positive hits 767 in 765 different sequences
Number of 'unknown' hits 1
Number of false positive hits 135 in 135 different sequences
Number of false negative sequences 267
Number of 'partial' sequences 5
Precision (true positives / (true positives + false positives)) 85.03 %
Recall (true positives / (true positives + false negatives)) 74.18 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Site [info] active_site at position 5
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 765 sequences 

12AH_CLOS4  (P21215), 25KD_SARPE  (P23170), 3AHDP_MEDG7 (A7B3K3),
» more

UniProtKB/Swiss-Prot
False negative sequences		 267 sequences 

3AHD_EGGLE  (C8WMP0), AAR_SYNE7   (Q54765), AAR_SYNY3   (Q55687),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 5 sequences 

ADHR_DROYA  (P28487), BDH_MESAU   (P86198), DIDH_PSESP  (P80701),
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

MCR2_ECOLX  (A0A1C3NEV1)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			135 sequences
			


			
A18_YMTV5   (Q6TUQ9), ABCGL_DICDI (Q8T673), AGL12_HALVD (D4GU72), 

			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			364 PDB
			


			1A27; 1A4U; 1AE1; 1AHH; 1AHI; 1B14; 1B15; 1B16; 1B2L; 1BDB; 1BHS; 1CYD; 
			
			

			» more