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PROSITE entry PS00018


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00018
Entry name [info] EF_HAND_1
Accession [info] PS00018
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00018
Associated ProRule [info] PRU10142

Name and characterization of the entry

Description [info] EF-hand calcium-binding domain.
Pattern [info]
D-{W}-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-[DENQSTAGC]-x(2)-
[DE]-[LIVMFYW].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 4'053 in 2'154 different sequences
Number of true positive hits 3'384 in 1'502 different sequences
Number of 'unknown' hits 39 in 28 different sequences
Number of false positive hits 630 in 624 different sequences
Number of false negative sequences 164
Number of 'partial' sequences 10
Precision (true positives / (true positives + false positives)) 84.30 %
Recall (true positives / (true positives + false negatives)) 95.38 %

Comments [info]

Taxonomic range [info] Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 7
Site [info] calcium at position 1
Site [info] calcium at position 3
Site [info] calcium at position 5
Site [info] calcium at position 7
Site [info] calcium at position 9
Site [info] calcium at position 11
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
1502 sequences

2AB2A_ARATH (Q9XGR4), 2AB2B_ARATH (Q5QIT3), 2AB2C_ARATH (Q8VZQ4), 
ยป more

UniProtKB/Swiss-Prot
False negative sequences
164 sequences

ACTN2_CHICK (P20111), ACTN4_CHICK (Q90734), ACTN_DERFA  (L7UZ85), 
ยป more

UniProtKB/Swiss-Prot
'Partial' sequences
10 sequences

CALM_LYTPI  (P05935), CALM_TETTH  (Q05055), CCB23_HOMAM (P80364), 
ยป more

UniProtKB/Swiss-Prot
'Unknown' sequences
28 sequences

CAPSD_HASV6 (Q67815), CHIT_STRLI  (P36909), CHIT_STRPL  (P11220), 
ยป more

UniProtKB/Swiss-Prot
False positive sequences
624 sequences

041R_FRG3G  (Q6GZT5), 4CLL3_ARATH (Q3E6Y4), 4CLL5_ARATH (Q84P21), 
ยป more

PDB
[Detailed view]
1218 PDB

1A03; 1A29; 1A2X; 1A75; 1AHR; 1AJ4; 1AJ5; 1AK8; 1ALV; 1ALW; 1AP4; 1AUI;
ยป more