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PROSITE entry PS00018


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00018
Entry name [info] EF_HAND_1
Accession [info] PS00018
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00018
Associated ProRule [info] PRU10142

Name and characterization of the entry

Description [info] EF-hand calcium-binding domain.
Pattern [info] 
D-{W}-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-[DENQSTAGC]-x(2)-
[DE]-[LIVMFYW].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 4'059 in 2'157 different sequences
Number of true positive hits 3'390 in 1'505 different sequences
Number of 'unknown' hits 39 in 28 different sequences
Number of false positive hits 630 in 624 different sequences
Number of false negative sequences 164
Number of 'partial' sequences 10
Precision (true positives / (true positives + false positives)) 84.33 %
Recall (true positives / (true positives + false negatives)) 95.39 %

Comments [info]

Taxonomic range [info] Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 7
Site [info] calcium at position 1
Site [info] calcium at position 3
Site [info] calcium at position 5
Site [info] calcium at position 7
Site [info] calcium at position 9
Site [info] calcium at position 11
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 1505 sequences 

2AB2A_ARATH (Q9XGR4), 2AB2B_ARATH (Q5QIT3), 2AB2C_ARATH (Q8VZQ4),
ยป more

UniProtKB/Swiss-Prot
False negative sequences		 164 sequences 

ACTN2_CHICK (P20111), ACTN4_CHICK (Q90734), ACTN_DERFA  (L7UZ85),
ยป more

UniProtKB/Swiss-Prot
'Partial' sequences		 10 sequences 

CALM_LYTPI  (P05935), CALM_TETTH  (Q05055), CCB23_HOMAM (P80364),
ยป more

UniProtKB/Swiss-Prot
'Unknown' sequences		 28 sequences 

CAPSD_HASV6 (Q67815), CHIT_STRLI  (P36909), CHIT_STRPL  (P11220),
ยป more

UniProtKB/Swiss-Prot
False positive sequences		 624 sequences 

041R_FRG3G  (Q6GZT5), 4CLL3_ARATH (Q3E6Y4), 4CLL5_ARATH (Q84P21),
ยป more

PDB
[Detailed view]		 1231 PDB

1A03; 1A29; 1A2X; 1A75; 1AHR; 1AJ4; 1AJ5; 1AK8; 1ALV; 1ALW; 1AP4; 1AUI;
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