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PDOC51051

DSL domain profile

Description:

The about 50 amino acids DSL (Delta / Serrate / Lag-2) domain is an extracellular domain essential to activate members of the Lin-12/Notch receptors family. The DSL domain may mediates oligomerization of DSL proteins to form an active ligand and mediates interaction with the extracellular domain of Lin-12/Notch proteins involved in cell-cell signaling interactions [1,2,3]. The DSL domain is found followed by a variable number of tandemly repeated copies of EGF motifs (see <PDOC00021>). Like EGF motifs this domain contains six conserved cysteines spanning different sequence lengths. Furthermore, the DSL domain contains a conserved YYG motif not present in the EGF motifs.

Proteins currently known to contain a DSL domain are:

  • The mammalian Serrate proteins, which are ligands for Notch receptors essential for the differenciation of certain tissues.
  • The human JAG1 and the Drosophila Delta proteins. They are ligands for multiple Notch receptors and are involved in the mediation of Notch signaling [4].
  • The Caenorhabditis elegans lag-2/Apx1 proteins which are signaling ligands for the glp-1 and lin-12 receptors [3].

The profile we developed covers the entire DSL domain.

Last update:

December 2004 / First entry.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

DSL, PS51051; DSL domain profile  (MATRIX)
Sequences known to belong to this class detected by the profile: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Domain architecture view of Swiss-Prot proteins matching PS51051
PS51051
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS51051
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS51051
• Scan Swiss-Prot/TrEMBL entries against PS51051
• view ligand binding statistics
Matching PDB structures: 2VJ2 [ALL]

References:

1 AuthorsArtavanis-Tsakonas S., Matsuno K., Fortini M.E.
SourceScience 268:225-232(1995).
2 AuthorsFitzgerald K., Greenwald I.
TitleInterchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo.
SourceDevelopment 121:4275-4282(1995).
PubMed ID8575327
3 AuthorsHenderson S.T., Gao D., Lambie E.J., Kimble J.
Titlelag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans.
SourceDevelopment 120:2913-2924(1994).
PubMed ID7607081
4 AuthorsYuan Z.R., Okaniwa M., Nagata I., Tazawa Y., Ito M., Kawarazaki H., Inomata Y., Okano S., Yoshida T., Kobayashi N., Kohsaka T.
TitleThe DSL domain in mutant JAG1 ligand is essential for the severity of the liver defect in Alagille syndrome.
SourceClin. Genet. 59:330-337(2001).
PubMed ID11359464

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Miscellaneous:

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