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PDOC00922

Ribosomal protein L1 signature

Description:

Ribosomal protein L1 is the largest protein from the large ribosomal subunit. In Escherichia coli, L1 is known to bind to the 23S rRNA. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2], groups:

  • Eubacterial L1.
  • Algal and plant chloroplast L1.
  • Cyanelle L1.
  • Archaebacterial L1.
  • Vertebrate L10A.
  • Yeast SSM1.

As a signature pattern, we selected the best conserved region located in the central section of these proteins. It is located at the end of an α helix thought to be involved in RNA-binding.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_L1, PS01199; Ribosomal protein L1 signature  (PATTERN)
Consensus pattern: [IMGV] - x(2) - [LIVA] - x(2,3) - [LIVMY] - [GAS] - x(2) - [LMSF] - [GSNH] - [PTKR] - [KRAVG] - [GN] - x - [LIMF] - P - [DENSTKQPRAGVI]
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01199
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01199
• Scan Swiss-Prot/TrEMBL entries against PS01199
• view ligand binding statistics
Matching PDB structures: 1AD2 1CJS 1DWU 1EG0 ... [ALL]

References:

1 AuthorsNikonov S., Nevskaya N., Eliseikina I., Fomenkova N., Nikulin A., Ossina N., Garber M., Jonsson B.-H., Briand C., Al-Karadaghi S., Svensson A., Aevarsson A., Liljas A.
TitleCrystal structure of the RNA binding ribosomal protein L1 from Thermus thermophilus.
SourceEMBO J. 15:1350-1359(1996).
PubMed ID8635468
2 AuthorsOlvera J., Wool I.G.
TitleThe primary structure of rat ribosomal protein L10a.
SourceBiochem. Biophys. Res. Commun. 220:954-957(1996).
PubMed ID8607874

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