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| PDOC00906 |
Anaphylatoxin domain signature and profile
Description:
Anaphylatoxins [1] are mediators of local inflammatory process that act by
inducing smooth muscle contraction. There are three different anaphylatoxins:
C3a, C4a and C5a. They are peptides of about 75 amino-acid residues that are
derived from the proteolytic degradation of complement C3, C4 and C5 and which
contains six disulfide-bonded cysteines [2] (see the schematic representation
below).
+--------------------+
+-------------|------------+ |
| | | |
xxxCCxxxxxxxxxxxxCxxxxxxxxxxxxCxxxxxxCCxxx
| |
+--------------------------------+
'C': conserved cysteine involved in a disulfide bond.
This cysteine-rich region shares similarity with a three times repeated domain
found in the mammalian extracellular matrix proteins fibulins 1 and 2 [3,4].
The three disulfide bonds are conserved in the first and last repeats, but the
first disulfide bond is missing in the second repeat.
Our consensus pattern spans the entire cysteine-rich domain.
Last update:
May 2004 / Text revised.
Technical section:
PROSITE methods (with tools and information) covered by this documentation:
| ANAPHYLATOXIN_2, PS01178; Anaphylatoxin domain profile (MATRIX) |
| Sequences known to belong to this class detected by the profile: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
|
|
|
| Matching PDB structures:
1C5A 1CFA 1KJS 2A73 ... [ALL] |
| ANAPHYLATOXIN_1, PS01177; Anaphylatoxin domain signature (PATTERN) |
| Consensus pattern: |
[CSH] - C - x(2) - [GAP] - x(7,8) - [GASTDEQR] - C - [GASTDEQL] - x(3,9) - [GASTDEQN] - x(2) - [CE] - x(6,7) - C - C
The 6 C's are involved in disulfide bonds |
| Sequences known to belong to this class detected by the pattern: |
ALL |
| Other sequence(s) detected in Swiss-Prot: |
NONE. |
|
|
|
| Matching PDB structures:
1C5A 1CFA 1KJS 2A73 ... [ALL] |
References:
| 1 |
Authors | Hugli T.E. |
| Title | Biochemistry and biology of anaphylatoxins. |
| Source | Complement 3:111-127(1986). |
| PubMed ID | 3542363 |
| 2 |
Authors | Huber R., Scholze H., Paques E.P., Deisenhofer J. |
| Title | Crystal structure analysis and molecular model of human C3a anaphylatoxin. |
| Source | Hoppe-Seyler's Z. Physiol. Chem. 361:1389-1399(1980). |
| PubMed ID | 7439885 |
| 3 |
Authors | Argraves W.S., Tran H., Burgess W.H., Dickerson K. |
| Title | Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure. |
| Source | J. Cell Biol. 111:3155-3164(1990). |
| PubMed ID | 2269669 |
| 4 |
Authors | Pan T.-C., Sasaki T., Zhang R.-Z., Faessler R., Timpl R., Chu M.L. |
| Title | Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. |
| Source | J. Cell Biol. 123:1269-1277(1993). |
| PubMed ID | 8245130 |
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