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PDOC00855

RNA polymerases K / 14 to 18 Kd subunits signature

Description:

In eukaryotes, there are three different forms of DNA-dependent RNA polymerases (EC 2.7.7.6) transcribing different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. In archaebacteria, there is generally a single form of RNA polymerase which also consist of an oligomeric assemblage of 10 to 13 polypeptides.

A component of 14 to 18 Kd shared by all three forms of eukaryotic RNA polymerases and which has been sequenced in budding yeast (gene RPB6 or RPO26), in fission yeast (gene rpb6 or rpo15), in human and in African swine fever virus [1] is evolutionary related [2] to archaebacterial subunit K (gene rpoK). The archaebacterial protein is colinear with the C-terminal part of the eukaryotic subunit.

Last update:

November 1997 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

RNA_POL_K_14KD, PS01111; RNA polymerases K / 14 to 18 Kd subunits signature  (PATTERN)
Consensus pattern: [ST] - x - [FY] - E - x - [AT] - R - x - [LIVM] - [GSA] - x - R - [SA] - x - Q
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE
• Retrieve an alignment of Swiss-Prot true positive hits:
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• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01111
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01111
• Scan Swiss-Prot/TrEMBL entries against PS01111
• view ligand binding statistics
Matching PDB structures: 1I3Q 1I50 1I6H 1K83 ... [ALL]

References:

1 AuthorsLu Z., Kutish G.F., Sussman M.D., Rock D.L.
TitleAn African swine fever virus gene with a similarity to eukaryotic RNA polymerase subunit 6.
SourceNucleic Acids Res. 21:2940-2940(1993).
PubMed ID8332503
2 AuthorsMcKune K., Woychik N.A.
TitleHalobacterial S9 operon contains two genes encoding proteins homologous to subunits shared by eukaryotic RNA polymerases I, II, and III.
SourceJ. Bacteriol. 176:4754-4756(1994).
PubMed ID8045907

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