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PDOC00779

Glycoprotease family signature

Description:

Glycoprotease (GCP) (EC 3.4.24.57) [1], or o-syaloglycoprotein endopeptidase, is a metalloprotease secreted by Pasteurella haemolytica which specifically cleaves O-sialoglycoproteins such as glycophorin A. The sequence of GCP is highly similar to uncharacterized orthologs in most complete genomes of bacteria and archaebacteria as well as in yeast (QRI7 and YKR038c).

One of the conserved regions contains two conserved histidines. It is possible that this region is involved in coordinating a metal ion such as zinc.

Note:

These proteins belong to family M22 in the classification of peptidases [2,E1].

Expert(s) to contact by email:

Lo R.Y.C.

Last update:

April 2006 / Pattern revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

GLYCOPROTEASE, PS01016; Glycoprotease family signature  (PATTERN)
Consensus pattern: [KRC] - [GSAT] - x(4) - [FYWLMH] - [DQNGKRH] - x - P - x - [LIVMFY] - x(3) - H - x(2) - [GSA] - H - [LIVMFA]
The 2 H's may be zinc ligands
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS01016
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS01016
• Scan Swiss-Prot/TrEMBL entries against PS01016
• view ligand binding statistics
Matching PDB structures: 2IVN 2IVO 2IVP 2VWB ... [ALL]

References:

1 AuthorsAbdullah K.M., Lo R.Y.C., Mellors A.
TitleCloning, nucleotide sequence, and expression of the Pasteurella haemolytica A1 glycoprotease gene.
SourceJ. Bacteriol. 173:5597-5603(1991).
PubMed ID1885539
2 AuthorsRawlings N.D., Barrett A.J.
TitleEvolutionary families of metallopeptidases.
SourceMethods Enzymol. 248:183-228(1995).
PubMed ID7674922
E1 Sourcehttp://www.expasy.org/cgi-bin/lists?peptidas.txt

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