PROSITE documentation PDOC00727UbiA prenyltransferase family signature
Description
The following prenyltransferases are evolutionary related [1,2]:
- Bacterial 4-hydroxybenzoate octaprenyltransferase (gene ubiA).
- Yeast mitochondrial para-hydroxybenzoate--polyprenyltransferase (gene COQ2).
- Protoheme IX farnesyltransferase (heme O synthase) from yeast and mammals (gene COX10) and from bacteria (genes cyoE or ctaB).
These proteins probably contain seven transmembrane segments. The best conserved region is located in a loop between the second and third of these segments and we used it as a signature pattern.
Last update:April 2006 / Pattern revised.
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Technical section
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References
| 1 | Authors | Melzer M. Heide L. |
| Title | Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli. | |
| Source | Biochim. Biophys. Acta 1212:93-102(1994). | |
| PubMed ID | 8155731 |
| 2 | Authors | Mogi T. Saiki K. Anraku Y. |
| Title | Biosynthesis and functional role of haem O and haem A. | |
| Source | Mol. Microbiol. 14:391-398(1994). | |
| PubMed ID | 7885224 |
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