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PROSITE documentation PDOC00390

6-phosphogluconate dehydrogenase signature

Description:

6-phosphogluconate dehydrogenase (EC 1.1.1.44) (6PGD) catalyzes the third step in the hexose monophosphate shunt, the decarboxylating reduction of 6-phosphogluconate in to ribulose 5-phosphate.

Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved [1]. As a signature pattern we have selected a region which has been shown [2], from studies of the sheep 6PGD tertiary structure, to be involved in the binding of 6-phosphogluconate.

Last update:

December 2004 / Pattern and text revised.

Technical section:

PROSITE method (with tools and information) covered by this documentation:

6PGD, PS00461; 6-phosphogluconate dehydrogenase signature  (PATTERN)
Consensus pattern: [LIVM] - x - [DG] - x(2) - [GAEHS] - [NQSD] - [KS] - G - [TE] - G - x - W
Sequences known to belong to this class detected by the pattern: ALL
Other sequence(s) detected in Swiss-Prot: NONE.
• Retrieve an alignment of Swiss-Prot true positive hits:
  Clustal format, color, condensed view  / Clustal format, color  / Clustal format, plain text  / Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic tree view of all Swiss-Prot/TrEMBL entries matching PS00461
• Retrieve a list of all Swiss-Prot/TrEMBL entries matching PS00461
• Scan Swiss-Prot/TrEMBL entries against PS00461
• view ligand binding statistics
Matching PDB structures: 1PGJ 1PGN 1PGO 1PGP ... [ALL]

References:

1 AuthorsReizer A., Deutscher J., Saier M.H. Jr., Reizer J.
TitleAnalysis of the gluconate (gnt) operon of Bacillus subtilis.
SourceMol. Microbiol. 5:1081-1089(1991).
PubMed ID1659648
2 AuthorsAdams M.J., Archibald I.G., Bugg C.E., Carne A., Gover S., Helliwell J.R., Pickersgill R.W., White S.W.
TitleThe three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution.
SourceEMBO J. 2:1009-1014(1983).
PubMed ID6641716

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