Enolase (EC 4.2.1.11) is a glycolytic enzyme that catalyzes the dehydration of
2-phospho-D-glycerate to phosphoenolpyruvate [1]. It is a dimeric enzyme that
requires magnesium both for catalysis and stabilizing the dimer. Enolase is
probably found in all organisms that metabolize sugars. In vertebrates, there
are three different tissue-specific isozymes: α present in most tissues,
β in muscles and γ found only in nervous tissues.
Tau-crystallin, one of the major lens proteins in some fish, reptiles and
birds, has been shown [2] to be evolutionary related to enolase.
As a signature pattern for enolase, we selected the best conserved region, it
is located in the C-terminal third of the sequence.
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