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Pierre-Alain Binz 

Postal address:
Swiss Institute of Bioinformatics
1, Michel-Servet
CH-1211 Genève 4
Switzerland 

Phone Number:

 +41-22-379 50 50 (secretary) 

Fax Number:
+41-22-379 58 58 

email address:

Welcome.

Native from Fribourg, Switzerland, I obtained a scientific maturity at the Collège St-Michel in 1987. In 1991 I got a degree in chemistry at the Department of Chemistry of the University of Fribourg where I did a diploma thesis in physical chemistry and another one in organic chemistry. In 1996 I have completed my PhD thesis at the Institute of Biochemistry of the University of Zürich in the group of Prof. Jeremias H.R. Kägi. Then I've been working as a postdoc at the Clinical Chemistry Central Laboratory of the Geneva University Hospital in the research group of Prof. Denis Hochstrasser (LCCC-2D) and at the Medical Biochemistry Departement of the Medicine Faculty at the University of Geneva with Prof. Amos Bairoch.
I'm now senior scientist in the Proteome Informatics group of Prof. Ron Appel at the Swiss Institute of Bioinformatics (SIB).

My current interests are focused on the development and the use of technologies dedicated to proteomics, i.e. the global and large scale analysis of proteins. This includes technologies like two-dimensional electrophoresis, liquid chromatography and mass spectrometry. On the bioinformatics side, I'm involved in design and development of protein identification and characterization tools, protein and genomic sequence databases, the implementation of a LIMS (laboratory information management system). I'm still taking care of the Metallothionein website, a reminiscence of my PhD time.


My activities and research projects at the Geneva University Hospital and at the Swiss Institute of Bioinformatics

Note: This aspect of the web page is (still) under construction.
I have the scientific responsabilities of the proteomics projects related to the identification and characterisation of protein using mass spectrometry within the PI group and in collaboration with the BPRG.
I'm coordinating the activities of the SIB and of the BPRG within some European networks.
I'm also leading the working group "mass spectrometry" of the Swiss Clinical Chemistry Society
Among others I'm also involved in various teaching environments, like the GeneBio bioinformatics course, the last EMBO course in Bioinformatics hold in Uppsala University in Sweden in August 2001, the year 2000 INSERM "atelier de formation 115". etc.

Antoine de Daruvar (LION Biosciences) and myself have recently organised a workshop in data integration in Functional Genomics and proteomics in Geneva, October 15-17th, 2001, financed by a European Science Fundation program. Go and have a look at the workshop homepage or at the Functional Genomics ESF network web page. 


My research projects at the University of Zürich

The clue of the various projects I was involved in during my PhD was the study of the family of small metal-binding proteins: the Metallothioneins (MTs).
The various aspects I have scrutinised were:
  • Analysis of the mechanism of molecular evolution of over 170 MTs. Use of phylogenetic methods applied to coding sequences and to selected non-coding segments of the respective genes. Use of other screening and correlation procedures for specific segments. Description of an evolutionary related classification system for MT. 
  • Characterisation of the blue crab Callinectes sapidus MT-I using optical and chiroptical spectroscopy (in collaboration with Dr. M. Brouwer of the University of Southern Mississippi) as well as NMR and MS specrometry. 
  • Design, synthesis and spectroscopic characterisation of Metallothionein model peptides.
  • Testing a theoretical model for the simulation of the (chir-)optical properties of metal-thiolate complexes/clusters and for the prediction of the spatial structure of these clusters.
  • Design of an object-oriented protein database in collaboration with the group of Prof. K. Dittrich at the Institute for Informatics, University of Zürich.

 

If you are interested in more details in Metallothionein or in the work I produced during my PhD, see the Metallothionein homepage.


Homepage/ Curriculum Vitae/
Metallothionein page/links
Pierre-Alain Binz
Last update May 15th 2005

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