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ENZYME

ENZYME entry: EC 7.1.1.1

Accepted Name
proton-translocating NAD(P)(+) transhydrogenase
Reaction catalysed
H(+)(in) + NAD(+) + NADPH <=> H(+)(out) + NADH + NADP(+)
Comment(s)
  • The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane.
  • In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH.
  • Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme.
  • Formerly EC 1.6.1.2 and EC 1.6.1.5.
Cross-references
BRENDA7.1.1.1
EC2PDB7.1.1.1
ExplorEnz7.1.1.1
PRIAM enzyme-specific profiles7.1.1.1
KEGG Ligand Database for Enzyme Nomenclature7.1.1.1
IUBMB Enzyme Nomenclature7.1.1.1
IntEnz7.1.1.1
MEDLINEFind literature relating to 7.1.1.1
MetaCyc7.1.1.1
Rhea expert-curated reactions7.1.1.1
UniProtKB/Swiss-Prot
P11024, NNTM_BOVINQ13423, NNTM_HUMANQ61941, NNTM_MOUSE
W5PFI3, NNTM_SHEEPQ2RSB2, PNTAA_RHORTP0C186, PNTAA_RHORU
P41077, PNTAA_RICPRQ2RSB3, PNTAB_RHORTP0C187, PNTAB_RHORU
P51995, PNTAB_RICPRQ9ALA2, PNTA_CERSPP07001, PNTA_ECOLI
P43842, PNTA_HAEINP0AB69, PNTB_ECO57P0AB68, PNTB_ECOL6
P0AB67, PNTB_ECOLIP43010, PNTB_HAEINQ2RSB4, PNTB_RHORT
P0C188, PNTB_RHORUP0AB70, PNTB_SHIFL

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