ID   6.3.5.5
DE   Carbamoyl-phosphate synthase (glutamine-hydrolyzing).
AN   Carbamoyl phosphate synthetase.
AN   Carbamoyl-phosphate synthetase (glutamine-hydrolyzing).
AN   Carbamoylphosphate synthetase II.
AN   Carbamyl phosphate synthetase (glutamine).
AN   CPS.
AN   GD-CPSase.
AN   Glutamine-dependent carbamoyl-phosphate synthase.
AN   Glutamine-dependent carbamyl phosphate synthetase.
CA   2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate
CA   + carbamoyl phosphate.
CC   -!- The product carbamoyl phosphate is an intermediate in the
CC       biosynthesis of arginine and the pyrimidine nucleotides.
CC   -!- The enzyme from Escherichia coli has three separate active sites,
CC       which are connected by a molecular tunnel that is almost 100 A in
CC       length.
CC   -!- The amidotransferase domain within the small subunit of the enzyme
CC       hydrolyzes glutamine to ammonia via a thioester intermediate.
CC   -!- The ammonia migrates through the interior of the protein, where it
CC       reacts with carboxy phosphate to produce the carbamate intermediate.
CC   -!- The carboxy-phosphate intermediate is formed by the phosphorylation
CC       of bicarbonate by ATP at a site contained within the N-terminal half
CC       of the large subunit.
CC   -!- The carbamate intermediate is transported through the interior of the
CC       protein to a second site within the C-terminal half of the large
CC       subunit, where it is phosphorylated by another ATP to yield the final
CC       product, carbamoyl phosphate.
CC   -!- Formerly EC 2.7.2.9.
PR   PROSITE; PDOC00405;
PR   PROSITE; PDOC00676;
PR   PROSITE; PDOC50975;
DR   Q6F8M7, CARA_ACIAD ;  Q8UDF7, CARA_AGRT5 ;  Q8YXQ7, CARA_ANASP ;
DR   O66727, CARA_AQUAE ;  O28995, CARA_ARCFU ;  Q752N9, CARA_ASHGO ;
DR   A1CA18, CARA_ASPCL ;  Q4WU09, CARA_ASPFU ;  A2R9B9, CARA_ASPNC ;
DR   Q2U913, CARA_ASPOR ;  Q81WF1, CARA_BACAN ;  Q732I2, CARA_BACC1 ;
DR   P52557, CARA_BACCL ;  Q819S2, CARA_BACCR ;  Q636D9, CARA_BACCZ ;
DR   Q9K9V8, CARA_BACHD ;  Q6HES7, CARA_BACHK ;  P25993, CARA_BACSU ;
DR   Q8G816, CARA_BIFLO ;  Q89DR8, CARA_BRAJA ;  Q8YIB8, CARA_BRUME ;
DR   Q8FZJ8, CARA_BRUSU ;  P57245, CARA_BUCAI ;  Q8K9Z6, CARA_BUCAP ;
DR   P59576, CARA_BUCBP ;  Q9PMG8, CARA_CAMJE ;  Q5AML6, CARA_CANAL ;
DR   Q6FQ30, CARA_CANGA ;  Q9A4J7, CARA_CAUCR ;  Q2H132, CARA_CHAGB ;
DR   Q8KGA2, CARA_CHLTE ;  Q97FT2, CARA_CLOAB ;  Q8XHB2, CARA_CLOPE ;
DR   Q1DUF5, CARA_COCIM ;  Q6NH15, CARA_CORDI ;  Q8FT41, CARA_COREF ;
DR   P58893, CARA_CORGL ;  O19886, CARA_CYACA ;  Q6BJG4, CARA_DEBHA ;
DR   Q9RWI4, CARA_DEIRA ;  Q8KZA0, CARA_DESVM ;  P0A6F2, CARA_ECO57 ;
DR   Q8FLB1, CARA_ECOL6 ;  P0A6F1, CARA_ECOLI ;  Q5BB37, CARA_EMENI ;
DR   Q6D0C8, CARA_ERWCT ;  Q8RG87, CARA_FUSNN ;  Q6B940, CARA_GRATL ;
DR   Q7VP66, CARA_HAEDU ;  Q8RSS4, CARA_HALER ;  Q9HP42, CARA_HALSA ;
DR   Q7VHS5, CARA_HELHP ;  Q9ZJY9, CARA_HELPJ ;  O25835, CARA_HELPY ;
DR   Q6CIQ1, CARA_KLULA ;  Q9CF80, CARA_LACLA ;  Q9L4N5, CARA_LACLM ;
DR   P77885, CARA_LACPL ;  Q72PK5, CARA_LEPIC ;  Q8F6R2, CARA_LEPIN ;
DR   Q92AH2, CARA_LISIN ;  Q71YI0, CARA_LISMF ;  Q8Y664, CARA_LISMO ;
DR   Q8TNY3, CARA_METAC ;  Q58425, CARA_METJA ;  Q8TY15, CARA_METKA ;
DR   Q8Q0U4, CARA_METMA ;  O27079, CARA_METTH ;  Q7U055, CARA_MYCBO ;
DR   Q9CCR3, CARA_MYCLE ;  Q741H2, CARA_MYCPA ;  P71811, CARA_MYCTU ;
DR   Q50983, CARA_NEIGO ;  Q9JVZ6, CARA_NEIMA ;  Q9JXX4, CARA_NEIMB ;
DR   A1CZ92, CARA_NEOFI ;  P22572, CARA_NEUCR ;  Q8CXH8, CARA_OCEIH ;
DR   Q9CKV3, CARA_PASMU ;  Q0U5H7, CARA_PHANO ;  Q7N8W2, CARA_PHOLL ;
DR   Q6LUK6, CARA_PHOPR ;  P51201, CARA_PORPU ;  Q1XDT6, CARA_PORYE ;
DR   P38098, CARA_PSEAE ;  Q88DU5, CARA_PSEPK ;  Q87WP3, CARA_PSESM ;
DR   P38099, CARA_PSEST ;  Q8ZY49, CARA_PYRAE ;  Q8U086, CARA_PYRFU ;
DR   Q8XZ85, CARA_RALSO ;  Q98IA7, CARA_RHILO ;  Q92N95, CARA_RHIME ;
DR   Q7UGJ6, CARA_RHOBA ;  Q9JP87, CARA_RHOGE ;  Q8Z9L8, CARA_SALTI ;
DR   P14845, CARA_SALTY ;  O60060, CARA_SCHPO ;  Q8EHS6, CARA_SHEON ;
DR   Q5HGN0, CARA_STAAC ;  P63729, CARA_STAAM ;  P99147, CARA_STAAN ;
DR   Q6GHN3, CARA_STAAR ;  Q6GA11, CARA_STAAS ;  P63730, CARA_STAAW ;
DR   Q5HPY9, CARA_STAEQ ;  Q8CPJ5, CARA_STAES ;  Q4L5Q4, CARA_STAHJ ;
DR   Q49WY3, CARA_STAS1 ;  P63731, CARA_STRA3 ;  P63732, CARA_STRA5 ;
DR   Q827Q8, CARA_STRAW ;  Q9KXR5, CARA_STRCO ;  Q8DUP4, CARA_STRMU ;
DR   P63735, CARA_STRP1 ;  P63736, CARA_STRP3 ;  Q5XCR8, CARA_STRP6 ;
DR   P58894, CARA_STRP8 ;  P63733, CARA_STRPN ;  P63734, CARA_STRR6 ;
DR   Q4J8E9, CARA_SULAC ;  Q59968, CARA_SULSO ;  Q970U8, CARA_SULTO ;
DR   Q67Q55, CARA_SYMTH ;  Q8DKU5, CARA_SYNEL ;  Q7U7F9, CARA_SYNPX ;
DR   P74587, CARA_SYNY3 ;  Q9HK16, CARA_THEAC ;  Q9WZ28, CARA_THEMA ;
DR   Q72GZ0, CARA_THET2 ;  Q8RBK1, CARA_THETN ;  Q97AJ4, CARA_THEVO ;
DR   P87183, CARA_TRIVE ;  Q9KPH8, CARA_VIBCH ;  Q87SF4, CARA_VIBPA ;
DR   Q8DEM1, CARA_VIBVU ;  Q7MNU1, CARA_VIBVY ;  Q8D3H7, CARA_WIGBR ;
DR   P58895, CARA_XANAC ;  P58896, CARA_XANCP ;  Q9PEC2, CARA_XYLFA ;
DR   Q87EB9, CARA_XYLFT ;  Q6C9Y4, CARA_YARLI ;  P07258, CARA_YEAST ;
DR   Q8ZIL5, CARA_YERPE ;  Q66ER8, CARA_YERPS ;  O50235, CARA_ZYMMO ;
DR   O67869, CARB1_AQUAE;  Q58773, CARB1_METJA;  Q8TWX0, CARB1_METKA;
DR   O67233, CARB2_AQUAE;  Q58776, CARB2_METJA;  Q8TUT7, CARB2_METKA;
DR   Q1IPK2, CARB_ACIBL ;  Q8UDE9, CARB_AGRT5 ;  Q8YQL2, CARB_ANASP ;
DR   O28994, CARB_ARCFU ;  A1R6Z3, CARB_ARTAT ;  A0JX72, CARB_ARTS2 ;
DR   Q75D66, CARB_ASHGO ;  A0RHQ8, CARB_BACAH ;  Q81WF2, CARB_BACAN ;
DR   Q732I3, CARB_BACC1 ;  P46537, CARB_BACCL ;  A7GRL1, CARB_BACCN ;
DR   Q819S3, CARB_BACCR ;  Q636E0, CARB_BACCZ ;  Q9K9V9, CARB_BACHD ;
DR   Q6HES8, CARB_BACHK ;  O50302, CARB_BACST ;  P25994, CARB_BACSU ;
DR   A1A0T4, CARB_BIFAA ;  Q8G815, CARB_BIFLO ;  Q8YIC2, CARB_BRUME ;
DR   Q8FZJ3, CARB_BRUSU ;  P57244, CARB_BUCAI ;  Q8K9Z7, CARB_BUCAP ;
DR   P59448, CARB_BUCBP ;  Q9PIL7, CARB_CAMJE ;  Q9A4D6, CARB_CAUCR ;
DR   A5CRX5, CARB_CLAM3 ;  B0REV9, CARB_CLAMS ;  Q97FT3, CARB_CLOAB ;
DR   A6LPD9, CARB_CLOB8 ;  A7GE89, CARB_CLOBL ;  Q0TM79, CARB_CLOP1 ;
DR   Q8XHB3, CARB_CLOPE ;  A9KI94, CARB_CLOPH ;  Q0SPY4, CARB_CLOPS ;
DR   Q8FT42, CARB_COREF ;  P58939, CARB_CORGL ;  Q1IWM0, CARB_DEIGD ;
DR   Q9RWK0, CARB_DEIRA ;  P63737, CARB_ECO57 ;  Q8FLB0, CARB_ECOL6 ;
DR   P00968, CARB_ECOLI ;  Q834E2, CARB_ENTFA ;  Q8RG86, CARB_FUSNN ;
DR   Q7VP67, CARB_HAEDU ;  Q8RSS3, CARB_HALER ;  Q9HP43, CARB_HALSA ;
DR   Q9ZKT2, CARB_HELPJ ;  O25577, CARB_HELPY ;  A2BJL3, CARB_HYPBU ;
DR   A6WCC6, CARB_KINRD ;  Q5FJC0, CARB_LACAC ;  Q038Z2, CARB_LACC3 ;
DR   Q047M8, CARB_LACDB ;  A8YVZ3, CARB_LACH4 ;  Q74J34, CARB_LACJO ;
DR   Q9CFV2, CARB_LACLA ;  O32771, CARB_LACLM ;  Q02YG5, CARB_LACLS ;
DR   P77886, CARB_LACPL ;  A5VHN6, CARB_LACRF ;  Q1WVA9, CARB_LACS1 ;
DR   Q38X24, CARB_LACSS ;  Q72NF1, CARB_LEPIC ;  Q8F832, CARB_LEPIN ;
DR   Q03WW7, CARB_LEUMM ;  Q92AH3, CARB_LISIN ;  Q71YI1, CARB_LISMF ;
DR   Q8Y665, CARB_LISMO ;  A0AJU0, CARB_LISW6 ;  Q8TNY4, CARB_METAC ;
DR   A7I6J1, CARB_METB6 ;  P13258, CARB_METBA ;  Q469Z7, CARB_METBF ;
DR   Q2FLD9, CARB_METHJ ;  A2SQ53, CARB_METLZ ;  P58944, CARB_METMA ;
DR   A3CU73, CARB_METMJ ;  A5UKG5, CARB_METS3 ;  O27077, CARB_METTH ;
DR   A0B8K9, CARB_METTP ;  Q7U054, CARB_MYCBO ;  A4TBY6, CARB_MYCGI ;
DR   Q9CCR2, CARB_MYCLE ;  A3PZ65, CARB_MYCSJ ;  A1UFK4, CARB_MYCSK ;
DR   Q1B9F9, CARB_MYCSS ;  P57689, CARB_MYCTU ;  A1T8H1, CARB_MYCVP ;
DR   Q1D6Y8, CARB_MYXXD ;  Q59599, CARB_NEIGO ;  Q9JW02, CARB_NEIMA ;
DR   Q9JXW8, CARB_NEIMB ;  Q04H29, CARB_OENOB ;  Q9CKV0, CARB_PASMU ;
DR   Q03HB0, CARB_PEDPA ;  A5D508, CARB_PELTS ;  Q6A914, CARB_PROAC ;
DR   P38100, CARB_PSEAE ;  Q88DU6, CARB_PSEPK ;  Q87WP4, CARB_PSESM ;
DR   Q8ZY48, CARB_PYRAE ;  Q8U085, CARB_PYRFU ;  Q8XZ83, CARB_RALSO ;
DR   A9WSA8, CARB_RENSM ;  Q98I87, CARB_RHILO ;  Q92PZ4, CARB_RHIME ;
DR   Q7UJ58, CARB_RHOBA ;  Q1AVY9, CARB_RUBXD ;  Q8Z9L7, CARB_SALTI ;
DR   P14846, CARB_SALTY ;  O94313, CARB_SCHPO ;  P63738, CARB_SHIFL ;
DR   A7X1F4, CARB_STAA1 ;  A6U122, CARB_STAA2 ;  Q2FHN5, CARB_STAA3 ;
DR   Q2FZ72, CARB_STAA8 ;  A5IS88, CARB_STAA9 ;  Q2YXG5, CARB_STAAB ;
DR   Q5HGM9, CARB_STAAC ;  A6QGA4, CARB_STAAE ;  P63739, CARB_STAAM ;
DR   P63740, CARB_STAAN ;  Q6GHN2, CARB_STAAR ;  Q6GA10, CARB_STAAS ;
DR   A8Z3P0, CARB_STAAT ;  P58940, CARB_STAAW ;  Q5HPY8, CARB_STAEQ ;
DR   Q8CPJ4, CARB_STAES ;  Q4L5Q5, CARB_STAHJ ;  Q49WY4, CARB_STAS1 ;
DR   Q3K150, CARB_STRA1 ;  Q8E5F5, CARB_STRA3 ;  Q8DZQ7, CARB_STRA5 ;
DR   Q827Q7, CARB_STRAW ;  Q9KXR6, CARB_STRCO ;  A8AX83, CARB_STRGC ;
DR   Q8DUP3, CARB_STRMU ;  Q9A0C6, CARB_STRP1 ;  Q04K48, CARB_STRP2 ;
DR   Q8K7Y3, CARB_STRP3 ;  Q5XCR6, CARB_STRP6 ;  P58941, CARB_STRP8 ;
DR   A2RF60, CARB_STRPG ;  Q97QE4, CARB_STRPN ;  Q8CWR0, CARB_STRR6 ;
DR   A3CNI5, CARB_STRSV ;  Q5M0W9, CARB_STRT1 ;  Q5M5F6, CARB_STRT2 ;
DR   Q03LT8, CARB_STRTD ;  Q4J8E8, CARB_SULAC ;  Q59969, CARB_SULSO ;
DR   Q970U7, CARB_SULTO ;  Q67Q54, CARB_SYMTH ;  Q55756, CARB_SYNY3 ;
DR   Q9HK17, CARB_THEAC ;  A8F453, CARB_THELT ;  Q9WZ27, CARB_THEMA ;
DR   A5IJL8, CARB_THEP1 ;  P96495, CARB_THET2 ;  Q5SKN1, CARB_THET8 ;
DR   Q8RBK0, CARB_THETN ;  Q97AJ3, CARB_THEVO ;  P46056, CARB_TRICU ;
DR   Q9KPH9, CARB_VIBCH ;  Q87SF3, CARB_VIBPA ;  Q8DEM2, CARB_VIBVU ;
DR   Q7MNU0, CARB_VIBVY ;  P58942, CARB_XANAC ;  P58943, CARB_XANCP ;
DR   Q9PEC1, CARB_XYLFA ;  Q87EB8, CARB_XYLFT ;  P03965, CARB_YEAST ;
DR   Q8ZIL4, CARB_YERPE ;  O50236, CARB_ZYMMO ;  Q9K8V6, CARX_BACHD ;
DR   P54324, CARX_BACST ;  P36838, CARX_BACSU ;  O08317, CARX_LACPL ;
DR   Q9K8V7, CARY_BACHD ;  Q9ZB63, CARY_BACST ;  P18185, CARY_BACSU ;
DR   Q9RLS9, CARY_LACPL ;  P20054, PYR1_DICDI ;  P05990, PYR1_DROME ;
DR   O93937, PYR1_EMENI ;  P27708, PYR1_HUMAN ;  P08955, PYR1_MESAU ;
DR   Q09794, PYR1_SCHPO ;  Q91437, PYR1_SQUAC ;  P07259, PYR1_YEAST ;
//