| Official Name |
|---|
| Tetrahydrofolate synthase.
|
| Alternative Name(s) |
|---|
| Folate polyglutamate synthetase. |
| Folylpoly(gamma-glutamate) synthase. |
| Folylpoly-gamma-glutamate synthase. |
| Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. |
| Folylpolyglutamate synthase. |
| Folylpolyglutamate synthetase. |
| Folylpolyglutamyl synthetase. |
| Formyltetrahydropteroyldiglutamate synthetase. |
| FPGS. |
| N(10)-formyltetrahydropteroyldiglutamate synthetase. |
| Tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming). |
| Tetrahydrofolylpolyglutamate synthase. |
| Reaction catalysed |
|---|
| ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate <=> ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1) |
| Comment(s) |
|---|
- In some bacteria, a single protein catalyzes both this activity and
that of EC 6.3.2.12, the combined activity of which leads to the
formation of the coenzyme polyglutamated tetrahydropteroate
(H(4)PteGlu(n)), i.e. various tetrahydrofolates (H(4)folate).
- In contrast, the activities are located on separate proteins in most
eukaryotes studied to date.
- In Arabidopsis thaliana, this enzyme is present as distinct isoforms
in the mitochondria, the cytosol and the chloroplast.
- Each isoform is encoded by a separate gene, a situation that is
unique among eukaryotes.
- As the affinity of folate-dependent enzymes increases markedly with
the number of glutamic residues, the tetrahydropteroyl polyglutamates
are the preferred coenzymes of C(1) metabolism.
- The enzymes from different sources (particularly eukaryotes versus
prokaryotes) have different substrate specificities with regard to
one-carbon substituents and the number of glutamate residues present
on the tetrahydrofolates.
|
| Cross-references |
|---|
| PROSITE | PDOC00773 |
| BRENDA | 6.3.2.17 |
| PUMA2 | 6.3.2.17 |
| PRIAM enzyme-specific profiles | 6.3.2.17 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.17 |
| IUBMB Enzyme Nomenclature | 6.3.2.17 |
| IntEnz | 6.3.2.17 |
| MEDLINE | Find literature relating to 6.3.2.17 |
| MetaCyc | 6.3.2.17 |
| UniProtKB/Swiss-Prot |
| Q05865, FOLC_BACSU; | A6H751, FOLC_BOVIN; | P57265, FOLC_BUCAI; |
| Q8K9X3, FOLC_BUCAP; | Q89AT2, FOLC_BUCBP; | Q09509, FOLC_CAEEL; |
| Q924L9, FOLC_CRIGR; | Q54CY5, FOLC_DICDI; | P08192, FOLC_ECOLI; |
| P43775, FOLC_HAEIN; | Q05932, FOLC_HUMAN; | P15925, FOLC_LACCA; |
| P48760, FOLC_MOUSE; | P36001, FOLC_YEAST; | Q9UTD0, FOLD_SCHPO; |
| Q12676, FOLD_YEAST; | Q9Y893, FOLE_CANAL; | O13492, FOLE_NEUCR; |
| O74742, FOLE_SCHPO; | Q08645, FOLE_YEAST; | P13337, VG29_BPT4; |
|
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