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ENZYME

ENZYME entry: EC 6.2.1.19

Accepted Name
long-chain-fatty-acid--protein ligase
Alternative Name(s)
acyl-protein synthetase
Reaction catalysed
a long-chain fatty acid + ATP + L-cysteinyl-[protein] <=> AMP + diphosphate + S-(long-chain fatty acyl)-L-cysteinyl-[protein]
Comment(s)
  • Together with a hydrolase component (EC 3.1.2.2/3.1.2.14) and a reductase component (EC 1.2.1.50), this enzyme forms a multienzyme fatty acid reductase complex that produces the long-chain aldehyde substrate of the bacterial luciferase enzyme (EC 1.14.14.3).
  • The enzyme activates free long-chain fatty acids, generated by the action of the transferase component, forming a fatty acyl-AMP intermediate, followed by the transfer of the acyl group to an internal L-cysteine residue.
  • It then transfers the acyl group to EC 1.2.1.50.
Cross-references
BRENDA6.2.1.19
EC2PDB6.2.1.19
ExplorEnz6.2.1.19
PRIAM enzyme-specific profiles6.2.1.19
KEGG Ligand Database for Enzyme Nomenclature6.2.1.19
IUBMB Enzyme Nomenclature6.2.1.19
IntEnz6.2.1.19
MEDLINEFind literature relating to 6.2.1.19
MetaCyc6.2.1.19
Rhea expert-curated reactions6.2.1.19
UniProtKB/Swiss-Prot
P24272, LUXE_ALIFSP29334, LUXE_PHOLEP19842, LUXE_PHOLU
P14286, LUXE_VIBHA

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