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NiceZyme View of ENZYME: EC 5.99.1.2

Accepted Name
DNA topoisomerase.
Alternative Name(s)
DNA topoisomerase I.
Nicking-closing enzyme.
Omega-protein.
Relaxing enzyme.
Swivelase.
Type I DNA topoisomerase.
Untwisting enzyme.
Reaction catalysed
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Comment(s)
Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
Cross-references
Biochemical Pathways; map number(s)R6 ; S6 ; S7
PROSITEPDOC00159 ; PDOC00333
BRENDA5.99.1.2
EC2PDB5.99.1.2
PRIAM enzyme-specific profiles5.99.1.2
KEGG Ligand Database for Enzyme Nomenclature5.99.1.2
IUBMB Enzyme Nomenclature5.99.1.2
IntEnz5.99.1.2
MEDLINEFind literature relating to 5.99.1.2
MetaCyc5.99.1.2
UniProtKB/Swiss-Prot
P07112, MOBA2_ECOLX;  Q7T6X9, TOP1E_MIMIV;  Q969P6, TOP1M_HUMAN;  
Q5UQB5, TOP1P_MIMIV;  Q9PHK2, TOP1P_XYLFA;  Q9YB01, TOP1_AERPE;  
O66893, TOP1_AQUAE;  P30181, TOP1_ARATH;  O28469, TOP1_ARCFU;  
P40114, TOP1_BACAN;  Q9KA23, TOP1_BACHD;  P34184, TOP1_BACPF;  
P39814, TOP1_BACSU;  O51768, TOP1_BORBU;  P57371, TOP1_BUCAI;  
Q8K9P7, TOP1_BUCAP;  O17966, TOP1_CAEEL;  Q9PLZ2, TOP1_CAMJE;  
Q00313, TOP1_CANAL;  Q7YR26, TOP1_CERAE;  Q07050, TOP1_CRIGR;  
P93119, TOP1_DAUCA;  Q54RC3, TOP1_DICDI;  P30189, TOP1_DROME;  
P06612, TOP1_ECOLI;  O34204, TOP1_FERIS;  P43012, TOP1_HAEIN;  
Q9ZMV7, TOP1_HELPJ;  P55991, TOP1_HELPY;  P11387, TOP1_HUMAN;  
P46155, TOP1_KLEAE;  Q9CG80, TOP1_LACLA;  Q59046, TOP1_METJA;  
O27661, TOP1_METTH;  Q04750, TOP1_MOUSE;  P0A621, TOP1_MYCBO;  
Q9JN65, TOP1_MYCGA;  P47368, TOP1_MYCGE;  O69548, TOP1_MYCLE;  
P78032, TOP1_MYCPN;  P0A620, TOP1_MYCTU;  Q9CN30, TOP1_PASMU;  
Q9HZJ5, TOP1_PSEAE;  Q9UYS8, TOP1_PYRAB;  O73954, TOP1_PYRFU;  
O58356, TOP1_PYRHO;  Q9WUL0, TOP1_RAT;  P16472, TOP1_RFVKA;  
Q1RIM1, TOP1_RICBR;  Q92IH1, TOP1_RICCN;  Q4UM42, TOP1_RICFE;  
Q9ZDK2, TOP1_RICPR;  Q68X45, TOP1_RICTY;  P0A2I2, TOP1_SALTI;  
P0A2I1, TOP1_SALTY;  P07799, TOP1_SCHPO;  Q2FHI8, TOP1_STAA3;  
Q2FZ32, TOP1_STAA8;  Q2YXL8, TOP1_STAAB;  Q5HGI2, TOP1_STAAC;  
Q99UM1, TOP1_STAAM;  Q7A5Y5, TOP1_STAAN;  Q6GHI5, TOP1_STAAR;  
Q6G9W3, TOP1_STAAS;  Q06AK7, TOP1_STAAU;  Q8NWZ9, TOP1_STAAW;  
Q5HPU2, TOP1_STAEQ;  Q8CSU3, TOP1_STAES;  Q4L5V2, TOP1_STAHJ;  
Q49X35, TOP1_STAS1;  Q9X909, TOP1_STRCO;  P34185, TOP1_SYNE7;  
P73810, TOP1_SYNY3;  Q9HM08, TOP1_THEAC;  P46799, TOP1_THEMA;  
O83409, TOP1_TREPA;  P41511, TOP1_USTMA;  Q76ZS7, TOP1_VACCA;  
P68697, TOP1_VACCC;  P68698, TOP1_VACCW;  P32989, TOP1_VARV;  
Q9KRB2, TOP1_VIBCH;  P41512, TOP1_XENLA;  Q9PEV8, TOP1_XYLFA;  
Q87AQ6, TOP1_XYLFT;  P04786, TOP1_YEAST;  Q9X3X7, TOP1_ZYMMO;  
Q9NG98, TOP3A_DROME;  Q13472, TOP3A_HUMAN;  O70157, TOP3A_MOUSE;  
O96651, TOP3B_DROME;  O95985, TOP3B_HUMAN;  Q9Z321, TOP3B_MOUSE;  
A0R979, TOP3_BACAH;  Q81Z97, TOP3_BACAN;  Q73E74, TOP3_BACC1;  
Q81IH1, TOP3_BACCR;  Q63GK5, TOP3_BACCZ;  Q6HP19, TOP3_BACHK;  
Q65N90, TOP3_BACLD;  Q5WAX6, TOP3_BACSK;  P96583, TOP3_BACSU;  
O61660, TOP3_CAEEL;  Q8T2T7, TOP3_DICDI;  P14294, TOP3_ECOLI;  
P43704, TOP3_HAEIN;  Q9CP53, TOP3_PASMU;  Q8Z6F5, TOP3_SALTI;  
P40687, TOP3_SALTY;  O60126, TOP3_SCHPO;  Q2FEN5, TOP3_STAA3;  
Q2FW03, TOP3_STAA8;  P0C2W6, TOP3_STAAB;  Q5HDV4, TOP3_STAAC;  
Q99S17, TOP3_STAAM;  Q7A455, TOP3_STAAN;  Q6GEH9, TOP3_STAAR;  
Q6G767, TOP3_STAAS;  Q7A075, TOP3_STAAW;  Q5HLZ4, TOP3_STAEQ;  
Q8CRF7, TOP3_STAES;  Q4L8B8, TOP3_STAHJ;  Q49ZH2, TOP3_STAS1;  
Q9KQF5, TOP3_VIBCH;  P13099, TOP3_YEAST;  

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