| Official Name |
|---|
| UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase.
|
| Alternative Name(s) |
|---|
| 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase. |
| UDP-alpha-D-GlcNAc3NAcA 2-epimerase. |
| UDP-GlcNAc3NAcA 2-epimerase. |
| Reaction catalysed |
|---|
| UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate |
| Comment(s) |
|---|
- Participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA
(UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid),
an important precursor of the B-band lipopolysaccharide of
Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of
Bordetella pertussis, both important respiratory pathogens.
- Highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-
acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc
(UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as
substrates.
|
| Cross-references |
|---|
| BRENDA | 5.1.3.23 |
| PUMA2 | 5.1.3.23 |
| PRIAM enzyme-specific profiles | 5.1.3.23 |
| KEGG Ligand Database for Enzyme Nomenclature | 5.1.3.23 |
| IUBMB Enzyme Nomenclature | 5.1.3.23 |
| IntEnz | 5.1.3.23 |
| MEDLINE | Find literature relating to 5.1.3.23 |
| MetaCyc | 5.1.3.23 |
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