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ENZYME

ENZYME entry: EC 5.1.3.17

Accepted Name
heparosan-N-sulfate-glucuronate 5-epimerase
Reaction catalysed
[heparosan-N-sulfate](n) <=> [heparan-N-sulfate](n)
Comment(s)
  • The enzyme acts on D-glucosyluronate residues in N-sulfated heparosan polymers, converting them to L-iduronate, thus modifying the polymer to heparan-N-sulfate.
  • The enzyme requires that at least the N-acetylglucosamine residue linked to C-4 of the substrate has been deacetylated and N-sulfated, and activity is highest with fully N-sulfated substrate.
  • It does not act on glucuronate residues that are O-sulfated or are adjacent to N-acetylglucosamine residues that are O-sulfated at the 6 position.
  • Thus the epimerization from D-glucuronate to L-iduronate occurs after N-sulfation of glucosamine residues but before O-sulfation.
  • Not identical with EC 5.1.3.19 or with EC 5.1.3.36.
Cross-references
BRENDA5.1.3.17
EC2PDB5.1.3.17
ExplorEnz5.1.3.17
PRIAM enzyme-specific profiles5.1.3.17
KEGG Ligand Database for Enzyme Nomenclature5.1.3.17
IUBMB Enzyme Nomenclature5.1.3.17
IntEnz5.1.3.17
MEDLINEFind literature relating to 5.1.3.17
MetaCyc5.1.3.17
Rhea expert-curated reactions5.1.3.17
UniProtKB/Swiss-Prot
F1QR43, GLCEB_DANREO18756, GLCE_BOVINP46555, GLCE_CAEEL
O94923, GLCE_HUMANQ9EPS3, GLCE_MOUSE

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