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NiceZyme View of ENZYME: EC 4.2.99.18

Official Name
DNA-(apurinic or apyrimidinic site) lyase.
Alternative Name(s)
AP endonuclease class I.
AP lyase.
Deoxyribonuclease (apurinic or apyrimidinic).
E.coli endonuclease III.
Endodeoxyribonuclease (apurinic or apyrimidinic).
Micrococcus luteus UV endonuclease.
Phage-T(4) UV endonuclease.
Phage-T4 UV endonuclease.
Reaction catalysed
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Comment(s)
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
Cross-references
Biochemical Pathways; map number(s)N8
PROSITEPDOC00598 ; PDOC00599 ; PDOC00615
BRENDA4.2.99.18
PUMA24.2.99.18
PRIAM enzyme-specific profiles4.2.99.18
KEGG Ligand Database for Enzyme Nomenclature4.2.99.18
IUBMB Enzyme Nomenclature4.2.99.18
IntEnz4.2.99.18
MEDLINEFind literature relating to 4.2.99.18
MetaCyc4.2.99.18
UniProtKB/Swiss-Prot
Q9YE60, AGOG_AERPE;  Q8TXW8, AGOG_METKA;  Q6M0G7, AGOG_METMP;  
Q74MX2, AGOG_NANEQ;  Q9UZY0, AGOG_PYRAB;  Q8ZVK6, AGOG_PYRAE;  
Q8U2D5, AGOG_PYRFU;  O58954, AGOG_PYRHO;  Q5JI79, AGOG_PYRKO;  
P51173, APEA_DICDI;  P23196, APEX1_BOVIN;  A1YES6, APEX1_GORGO;  
P27695, APEX1_HUMAN;  P28352, APEX1_MOUSE;  A1YFZ3, APEX1_PANPA;  
A2T6Y4, APEX1_PANTR;  A2T7I6, APEX1_PONPY;  P43138, APEX1_RAT;  
Q5E9N9, APEX2_BOVIN;  Q9UBZ4, APEX2_HUMAN;  Q68G58, APEX2_MOUSE;  
Q10002, APN1_CAEEL;  P50525, APN1_SCHPO;  P22936, APN1_YEAST;  
P87175, APN2_SCHPO;  P38207, APN2_YEAST;  P45951, ARP_ARATH;  
P39788, END3_BACSU;  P57219, END3_BUCAI;  Q8KA16, END3_BUCAP;  
Q89AW4, END3_BUCBP;  P0AB84, END3_ECOL6;  P0AB83, END3_ECOLI;  
P44319, END3_HAEIN;  P63541, END3_MYCBO;  Q9CB92, END3_MYCLE;  
P63540, END3_MYCTU;  Q92GH4, END3_RICCN;  Q4UK93, END3_RICFE;  
O05956, END3_RICPR;  Q68W04, END3_RICTY;  P73715, END3_SYNY3;  
Q9WYK0, END3_THEMA;  O83754, END3_TREPA;  A8AJA5, END8_CITK8;  
A7ZJ95, END8_ECO24;  Q8X9C6, END8_ECO57;  A7ZXX5, END8_ECOHS;  
A1A8X0, END8_ECOK1;  Q0TJX8, END8_ECOL5;  Q8FJU5, END8_ECOL6;  
B1IY15, END8_ECOLC;  P50465, END8_ECOLI;  Q1REK9, END8_ECOUT;  
A4W871, END8_ENT38;  A7MQW6, END8_ENTS8;  Q6D7H0, END8_ERWCT;  
A6T6E8, END8_KLEP7;  A9MJM8, END8_SALAR;  Q57RM1, END8_SALCH;  
Q5PCL7, END8_SALPA;  A9MTR2, END8_SALPB;  Q8Z8D2, END8_SALTI;  
Q8ZQU6, END8_SALTY;  Q324J6, END8_SHIBS;  Q32IL9, END8_SHIDS;  
Q0T6V4, END8_SHIF8;  Q83LZ7, END8_SHIFL;  Q3Z489, END8_SHISS;  
B0C5D4, FPG_ACAM1;  Q6FE90, FPG_ACIAD;  A0LV85, FPG_ACIC1;  
A5FZ95, FPG_ACICJ;  A1W4G6, FPG_ACISJ;  A3N3S8, FPG_ACTP2;  
A6VKA1, FPG_ACTSZ;  A0KEN2, FPG_AERHH;  A4STD1, FPG_AERS4;  
Q8UIH4, FPG_AGRT5;  Q0VLB7, FPG_ALCBS;  Q0A598, FPG_ALHEH;  
Q8YP80, FPG_ANASP;  Q3MDP1, FPG_ANAVT;  A8IQM5, FPG_AZOC5;  
Q5P728, FPG_AZOSE;  Q81L04, FPG_BACAN;  Q72ZF1, FPG_BACC1;  
Q817G5, FPG_BACCR;  Q633L1, FPG_BACCZ;  P19210, FPG_BACFI;  
Q9K855, FPG_BACHD;  Q6HCU5, FPG_BACHK;  Q65G93, FPG_BACLD;  
Q5WEG7, FPG_BACSK;  O34403, FPG_BACSU;  A1UU20, FPG_BARBK;  
Q6G4T2, FPG_BARHE;  Q6G0L3, FPG_BARQU;  A9IN26, FPG_BART1;  
Q1LTS6, FPG_BAUCH;  Q6ML45, FPG_BDEBA;  Q2KYB7, FPG_BORA1;  
Q7W185, FPG_BORPA;  Q7VUG7, FPG_BORPE;  Q89WC9, FPG_BRAJA;  
A5E887, FPG_BRASB;  A4YJG9, FPG_BRASO;  Q2YQP8, FPG_BRUA2;  
Q57A83, FPG_BRUAB;  A9MAB2, FPG_BRUC2;  Q8YED2, FPG_BRUME;  
A5VTD0, FPG_BRUO2;  Q8FXR6, FPG_BRUSU;  Q1BTH0, FPG_BURCA;  
A0KAM1, FPG_BURCH;  A2S6C0, FPG_BURM9;  Q62FC7, FPG_BURMA;  
A1UZN2, FPG_BURMS;  A3NRA1, FPG_BURP0;  Q3JW82, FPG_BURP1;  
A3N5K5, FPG_BURP6;  Q63XL4, FPG_BURPS;  Q39CU4, FPG_BURS3;  
Q2T1B3, FPG_BURTA;  A4JHZ1, FPG_BURVG;  Q145W8, FPG_BURXL;  
Q3ABL4, FPG_CARHZ;  Q9A259, FPG_CAUCR;  B0T7D1, FPG_CAUSK;  
A9WDC2, FPG_CHLAA;  Q7NQS5, FPG_CHRVO;  A8ARM2, FPG_CITK8;  
Q48AD4, FPG_COLP3;  Q6NGH4, FPG_CORDI;  Q8FP17, FPG_COREF;  
A4QFD9, FPG_CORGB;  Q8NNV7, FPG_CORGL;  Q4JUY8, FPG_CORJK;  
Q479M6, FPG_DECAR;  Q9RX22, FPG_DEIRA;  Q24XW2, FPG_DESHY;  
Q6APT2, FPG_DESPS;  A4J4X3, FPG_DESRM;  Q726D5, FPG_DESVH;  
A5EXK6, FPG_DICNV;  A8LNK8, FPG_DINSH;  A7ZTI6, FPG_ECO24;  
P64148, FPG_ECO57;  A8A697, FPG_ECOHS;  A1AHG8, FPG_ECOK1;  
Q0TBH4, FPG_ECOL5;  Q8FC87, FPG_ECOL6;  B1IZF8, FPG_ECOLC;  
P05523, FPG_ECOLI;  Q1R4V8, FPG_ECOUT;  A4W514, FPG_ENT38;  
Q837G3, FPG_ENTFA;  A7MQ97, FPG_ENTS8;  Q6DAV4, FPG_ERWCT;  
Q2N7Y8, FPG_ERYLH;  Q5NGY3, FPG_FRATT;  Q5KWC3, FPG_GEOKA;  
Q39WD1, FPG_GEOMG;  Q74EG5, FPG_GEOSL;  A5G7Q9, FPG_GEOUR;  
Q7NFW7, FPG_GLOVI;  A9HI30, FPG_GLUDA;  Q5FN17, FPG_GLUOX;  
Q7VN67, FPG_HAEDU;  Q4QLW2, FPG_HAEI8;  A5UDC3, FPG_HAEIE;  
A5UI87, FPG_HAEIG;  P44948, FPG_HAEIN;  Q0I0X6, FPG_HAES1;  
B0UUX0, FPG_HAES2;  Q2SPF3, FPG_HAHCH;  A1WZG2, FPG_HALHL;  
A4G916, FPG_HERAR;  Q5QZC1, FPG_IDILO;  A6T2R7, FPG_JANMA;  
Q28JI5, FPG_JANSC;  A6W7S6, FPG_KINRD;  A6TFM6, FPG_KLEP7;  
Q5FIV8, FPG_LACAC;  Q1G9A3, FPG_LACDA;  Q049F3, FPG_LACDB;  
Q041U1, FPG_LACGA;  A8YWE6, FPG_LACH4;  Q74IB5, FPG_LACJO;  
Q9CIK4, FPG_LACLA;  P42371, FPG_LACLC;  Q88WV4, FPG_LACPL;  
Q1WUN7, FPG_LACS1;  Q38VS5, FPG_LACSS;  Q5X7I9, FPG_LEGPA;  
Q5ZY18, FPG_LEGPH;  Q5WYY6, FPG_LEGPL;  Q6AFJ3, FPG_LEIXX;  
Q92BF1, FPG_LISIN;  Q71ZA3, FPG_LISMF;  Q8Y6W7, FPG_LISMO;  
A0L837, FPG_MAGSM;  Q65R59, FPG_MANSM;  A1U749, FPG_MARAV;  
A6VSY6, FPG_MARMS;  Q11AV8, FPG_MESSB;  Q602J1, FPG_METCA;  
Q1H3I3, FPG_METFK;  Q5UQ00, FPG_MIMIV;  Q2RHE9, FPG_MOOTA;  
A0QJ66, FPG_MYCA1;  P64151, FPG_MYCBO;  A1KMR9, FPG_MYCBP;  
P55825, FPG_MYCGE;  A4TE57, FPG_MYCGI;  O69470, FPG_MYCLE;  
Q6KHS0, FPG_MYCMO;  Q73VL9, FPG_MYCPA;  P75402, FPG_MYCPN;  
Q98QQ1, FPG_MYCPU;  A0QV21, FPG_MYCS2;  A3PXU1, FPG_MYCSJ;  
A1UED7, FPG_MYCSK;  Q1BAM5, FPG_MYCSS;  A5U6T0, FPG_MYCTA;  
P64150, FPG_MYCTU;  A0PQ49, FPG_MYCUA;  A1T737, FPG_MYCVP;  
Q5F8Z9, FPG_NEIG1;  P57014, FPG_NEIMA;  P55044, FPG_NEIMB;  
Q0AD66, FPG_NITEC;  Q82S12, FPG_NITEU;  Q2YBI1, FPG_NITMU;  
Q3J7U5, FPG_NITOC;  Q3SWN3, FPG_NITWN;  Q5YS09, FPG_NOCFA;  
A1SLU7, FPG_NOCSJ;  Q2GAT0, FPG_NOVAD;  Q8EPE6, FPG_OCEIH;  
A1BAN2, FPG_PARDP;  A7HZC4, FPG_PARL1;  Q6MCT3, FPG_PARUW;  
P57910, FPG_PASMU;  Q8VW76, FPG_PASPI;  Q03GC2, FPG_PEDPA;  
Q3A3F2, FPG_PELCD;  A1AV29, FPG_PELPD;  A5D0T6, FPG_PELTS;  
Q7MY36, FPG_PHOLL;  Q6LVN0, FPG_PHOPR;  A1VKP2, FPG_POLNA;  
Q12DZ5, FPG_POLSJ;  A3PB53, FPG_PROM0;  A2C0H4, FPG_PROM1;  
A8G2Y9, FPG_PROM2;  A2BUV8, FPG_PROM5;  Q31CK0, FPG_PROM9;  
Q7VDK6, FPG_PROMA;  Q7V8Y5, FPG_PROMM;  Q7V2X4, FPG_PROMP;  
A2BPD1, FPG_PROMS;  Q46H41, FPG_PROMT;  Q48CK1, FPG_PSE14;  
Q15ZV5, FPG_PSEA6;  A6UYG0, FPG_PSEA7;  Q02U58, FPG_PSEAB;  
Q9L7T2, FPG_PSEAE;  Q1IGF3, FPG_PSEE4;  Q4K4A5, FPG_PSEF5;  
A4Y028, FPG_PSEMY;  A5WAF9, FPG_PSEP1;  Q3K566, FPG_PSEPF;  
B0KN79, FPG_PSEPG;  Q88CQ5, FPG_PSEPK;  Q88AH6, FPG_PSESM;  
Q4ZM34, FPG_PSEU2;  A4VRM9, FPG_PSEU5;  Q4FUU7, FPG_PSYA2;  
A1SR12, FPG_PSYIN;  Q0KEP4, FPG_RALEH;  Q476F5, FPG_RALEJ;  
Q1LRP7, FPG_RALME;  Q8Y2D7, FPG_RALSO;  Q2KDA9, FPG_RHIEC;  
Q1MMD9, FPG_RHIL3;  Q98BG6, FPG_RHILO;  Q59752, FPG_RHIME;  
Q21XW7, FPG_RHOFD;  Q2J2I0, FPG_RHOP2;  Q07UF4, FPG_RHOP5;  
Q6NDM1, FPG_RHOPA;  Q21CD4, FPG_RHOPB;  Q13EN7, FPG_RHOPS;  
Q2RMQ2, FPG_RHORT;  A3PFL2, FPG_RHOS1;  Q3IY64, FPG_RHOS4;  
A4WVR6, FPG_RHOS5;  Q0S2E0, FPG_RHOSR;  A8GXR0, FPG_RICB8;  
Q1RJY6, FPG_RICBR;  A8EZP5, FPG_RICCK;  Q92GT4, FPG_RICCN;  
Q4UMW5, FPG_RICFE;  A8F2H0, FPG_RICM5;  B0BUU0, FPG_RICRO;  
A8GTA0, FPG_RICRS;  A7NQM8, FPG_ROSCS;  Q16DL0, FPG_ROSDO;  
A5UUN1, FPG_ROSS1;  A1AW02, FPG_RUTMC;  Q21EE3, FPG_SACD2;  
A4FMJ7, FPG_SACEN;  A8M661, FPG_SALAI;  A9MKN9, FPG_SALAR;  
Q57IA7, FPG_SALCH;  Q5PC09, FPG_SALPA;  A9MVN0, FPG_SALPB;  
Q8Z2H2, FPG_SALTI;  A4X4F8, FPG_SALTO;  O54326, FPG_SALTY;  
Q9X981, FPG_SERMA;  A8GLE2, FPG_SERP5;  A1S1S3, FPG_SHEAM;  
A3CYP7, FPG_SHEB5;  A6WUE9, FPG_SHEB8;  A9KW47, FPG_SHEB9;  
Q12SR9, FPG_SHEDO;  B0TN04, FPG_SHEHH;  A3QJA8, FPG_SHELP;  
Q8E8D9, FPG_SHEON;  A8HA27, FPG_SHEPA;  A0L2N2, FPG_SHESA;  
Q0HDC3, FPG_SHESM;  Q0HPK4, FPG_SHESR;  A1RE25, FPG_SHESW;  
Q31UZ1, FPG_SHIBS;  Q329M2, FPG_SHIDS;  Q0SYG3, FPG_SHIF8;  
P64149, FPG_SHIFL;  Q3YVZ7, FPG_SHISS;  Q5LWT9, FPG_SILPO;  
Q1GC55, FPG_SILST;  A6UFF8, FPG_SINMW;  Q2NQU4, FPG_SODGM;  
Q01RU9, FPG_SOLUE;  Q1GN82, FPG_SPHAL;  A5VG06, FPG_SPHWW;  
Q3K028, FPG_STRA1;  P64152, FPG_STRA3;  P64153, FPG_STRA5;  
Q82JU0, FPG_STRAW;  Q9ZBQ6, FPG_STRCO;  P55045, FPG_STRMU;  
Q9A131, FPG_STRP1;  Q8K8D0, FPG_STRP3;  Q5XDE4, FPG_STRP6;  
Q8P250, FPG_STRP8;  Q48UU6, FPG_STRPM;  Q97R61, FPG_STRPN;  
Q8DQ33, FPG_STRR6;  Q5M0P0, FPG_STRT1;  Q5M576, FPG_STRT2;  
Q67R59, FPG_SYMTH;  P59065, FPG_SYNEL;  P95744, FPG_SYNEN;  
Q08079, FPG_SYNP6;  Q7U4V2, FPG_SYNPX;  Q0AVE3, FPG_SYNWW;  
P74290, FPG_SYNY3;  Q47S77, FPG_THEFY;  Q72HN2, FPG_THET2;  
O50606, FPG_THET8;  Q31EB2, FPG_THICR;  Q3SLR9, FPG_THIDA;  
Q117D2, FPG_TRIEI;  Q9PQ76, FPG_UREPA;  A5CX90, FPG_VESOH;  
A5F407, FPG_VIBC3;  Q9KVC5, FPG_VIBCH;  Q5E8M1, FPG_VIBF1;  
A7MSN3, FPG_VIBHB;  Q87T81, FPG_VIBPA;  Q8DDY4, FPG_VIBVU;  
Q7MPS3, FPG_VIBVY;  Q73G10, FPG_WOLPM;  Q5GS47, FPG_WOLTR;  
Q8PEQ4, FPG_XANAC;  Q3BM92, FPG_XANC5;  Q4UNU6, FPG_XANC8;  
Q8P3C4, FPG_XANCP;  Q2P8V2, FPG_XANOM;  Q5H667, FPG_XANOR;  
P64154, FPG_XYLFA;  P64155, FPG_XYLFT;  A1JHR7, FPG_YERE8;  
A7FCT7, FPG_YERP3;  Q1C270, FPG_YERPA;  Q8ZJP0, FPG_YERPE;  
Q1CD05, FPG_YERPN;  A4TSD4, FPG_YERPP;  Q66GD3, FPG_YERPS;  
Q9X3X1, FPG_ZYMMO;  Q96FI4, NEIL1_HUMAN;  Q8K4Q6, NEIL1_MOUSE;  
Q6IE77, NEIL2_BOVIN;  Q969S2, NEIL2_HUMAN;  Q6R2P8, NEIL2_MOUSE;  
Q5RAJ7, NEIL2_PONAB;  P54137, NTH1_CAEEL;  Q09907, NTH1_SCHPO;  
Q2KID2, NTHL1_BOVIN;  P78549, NTHL1_HUMAN;  O35980, NTHL1_MOUSE;  
O66612, OGG1_AQUAE;  O29876, OGG1_ARCFU;  Q9V3I8, OGG1_DROME;  
Q8R689, OGG1_FUSNN;  O15527, OGG1_HUMAN;  Q58134, OGG1_METJA;  
A4YHC9, OGG1_METS5;  O27397, OGG1_METTH;  O08760, OGG1_MOUSE;  
Q6L1T6, OGG1_PICTO;  O70249, OGG1_RAT;  Q4J929, OGG1_SULAC;  
Q97ZK2, OGG1_SULSO;  Q972A8, OGG1_SULTO;  Q9HM55, OGG1_THEAC;  
Q9X2E1, OGG1_THEMA;  A5ILP7, OGG1_THEP1;  Q97CP1, OGG1_THEVO;  
P53397, OGG1_YEAST;  P19889, RLA0_DROME;  P27864, RRP1_DROME;  
P64158, Y2464_MYCTU;  P64159, Y2491_MYCBO;  P64156, Y3297_MYCTU;  
P64157, Y3325_MYCBO;  O86820, Y5760_STRCO;  

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