| Official Name |
|---|
| 6-pyruvoyltetrahydropterin synthase.
|
| Alternative Name(s) |
|---|
| 6-pyruvoyl tetrahydrobiopterin synthase. |
| PTPS. |
| Reaction catalysed |
|---|
| 7,8-dihydroneopterin 3'-triphosphate <=> 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate |
| Cofactor(s) |
|---|
| Magnesium.
|
| Comment(s) |
|---|
- Catalyzes triphosphate elimination and an intramolecular redox
reaction.
- The product is 6-pyruvoyltetrahydrobiopterin.
- Involved in the de novo synthesis of tetrahydrobiopterin from GTP,
with the other enzymes involved being EC 1.1.1.153 and EC 3.5.4.16.
- Formerly EC 4.6.1.10.
|
| Cross-references |
|---|
| PROSITE | PDOC00759 |
| BRENDA | 4.2.3.12 |
| PUMA2 | 4.2.3.12 |
| PRIAM enzyme-specific profiles | 4.2.3.12 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.3.12 |
| IUBMB Enzyme Nomenclature | 4.2.3.12 |
| IntEnz | 4.2.3.12 |
| MEDLINE | Find literature relating to 4.2.3.12 |
| MetaCyc | 4.2.3.12 |
| UniProtKB/Swiss-Prot |
| O66626, PTPS_AQUAE; | O29809, PTPS_ARCFU; | Q8K9D8, PTPS_BUCAP; |
| O02058, PTPS_CAEEL; | Q1ZXI0, PTPS_DICDI; | P48611, PTPS_DROME; |
| P65871, PTPS_ECO57; | P65870, PTPS_ECOLI; | P44123, PTPS_HAEIN; |
| Q9ZKR8, PTPS_HELPJ; | O25587, PTPS_HELPY; | Q03393, PTPS_HUMAN; |
| Q58668, PTPS_METJA; | O27296, PTPS_METTH; | Q9R1Z7, PTPS_MOUSE; |
| Q90W95, PTPS_POERE; | Q5REZ5, PTPS_PONAB; | Q9UXZ4, PTPS_PYRAB; |
| O59602, PTPS_PYRHO; | P27213, PTPS_RAT; | Q1RHI6, PTPS_RICBR; |
| Q92J44, PTPS_RICCN; | Q4UKI6, PTPS_RICFE; | Q9ZDY5, PTPS_RICPR; |
| Q68XI9, PTPS_RICTY; | P80081, PTPS_SALSA; | P65872, PTPS_SHIFL; |
| Q55798, PTPS_SYNY3; |
|
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