| Official Name |
|---|
| GDP-mannose 4,6-dehydratase.
|
| Alternative Name(s) |
|---|
| GDP-D-mannose 4,6-dehydratase. |
| GDP-D-mannose dehydratase. |
| Guanosine 5'-diphosphate-D-mannose oxidoreductase. |
| Guanosine diphosphomannose 4,6-dehydratase. |
| Guanosine diphosphomannose oxidoreductase. |
| Reaction catalysed |
|---|
| GDP-mannose <=> GDP-4-dehydro-6-deoxy-D-mannose + H(2)O |
| Cofactor(s) |
|---|
| NAD.
|
| Comment(s) |
|---|
- Forms the first step in the biosynthesis of GDP-D-rhamnose and GDP-L-
fucose.
- In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a
bifunctional enzyme, catalyzing the above reaction as well as the
reaction catalyzed by EC 1.1.1.281.
|
| Cross-references |
|---|
| BRENDA | 4.2.1.47 |
| PUMA2 | 4.2.1.47 |
| PRIAM enzyme-specific profiles | 4.2.1.47 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.1.47 |
| IUBMB Enzyme Nomenclature | 4.2.1.47 |
| IntEnz | 4.2.1.47 |
| MEDLINE | Find literature relating to 4.2.1.47 |
| MetaCyc | 4.2.1.47 |
| UniProtKB/Swiss-Prot |
| Q06952, GM4D1_VIBCH; | Q56598, GM4D2_VIBCH; | P0AC90, GM4D_ECO57; |
| P0AC89, GM4D_ECOL6; | P0AC88, GM4D_ECOLI; | Q51366, GM4D_PSEAE; |
| P0AC91, GM4D_SHIFL; | Q56872, GM4D_YERE8; | Q9SNY3, GMD1_ARATH; |
| A8Y0L5, GMD1_CAEBR; | Q18801, GMD1_CAEEL; | P93031, GMD2_ARATH; |
| O45583, GMD2_CAEEL; | Q8K3X3, GMDS_CRIGR; | Q1ZXF7, GMDS_DICDI; |
| Q9VMW9, GMDS_DROME; | O60547, GMDS_HUMAN; | Q8K0C9, GMDS_MOUSE; |
| O85713, NOEL_RHIFR; | P55354, NOEL_RHISN; |
|
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